Cat. No. | Product Name / Activity |
---|---|
6802 | 6 TMR Tre |
Fluorescent trehalose; selectively labels mycobacterial cell envelope | |
6803 | MRK 740 |
Potent PRDM9 inhibitor | |
6804 | Hoechst Janelia Fluor® 646 |
Fluorogenic, red-emitting DNA probe | |
6807 | NNC 0640 |
Negative allosteric modulator of glucagon and GLP-1 receptors | |
6811 | Lapatinib |
Potent and selective dual ErbB2 (HER-2) and EGFR inhibitor | |
6812 | Afatinib dimaleate |
Potent dual specificity EGFR/HER2 inhibitor; active in vivo | |
6813 | Ibrutinib |
Potent and selective BTK inhibitor | |
6814 | Sorafenib |
Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and cKIT | |
6816 | Sitagliptin phosphate |
Potent and selective DPP IV inhibitor | |
6817 | BAY 8002 |
Potent dual MCT1/2 inhibitor; orally bioavailable | |
6818 | Artemether |
Antimalarial; also inhibits neuroinflammation | |
6819 | Mefloquine hydrochloride |
Cx36 and Cx50 gap channel blocker; also antimalarial and antischistosomal | |
6821 | ZAP 180013 |
Zap70 inhibitor; inhibits interaction with ITAMs | |
6823 | CycLuc 1 |
Synthetic luciferase substrate; brain penetrant; displays NIR emission | |
6825 | SGC 3027 |
Potent and selective PRMT7 inhibitor | |
6826 | AZ 1729 |
FFA2 allosteric agonist; displays bias for the Gi signaling pathway | |
6827 | Artesunate |
Suppresses ROS-induced activation of the NLRP3 inflammasome; antimalarial | |
6830 | Conivaptan hydrochloride |
Very high affinity vasopressin V1A and V2 antagonist; orally bioavailable | |
6831 | TRPV3 74a |
Selective TRPV3 antagonist; brain penetrant | |
6832 | Ec2la |
Positive allosteric modulator of CB2 receptors; active in vivo | |
6833 | RO 5263397 hydrochloride |
Potent TA1 receptor agonist | |
6834 | Auxin |
Chemical dimerizer used in auxin-inducible degron (AID) system; phytohormone | |
6835 | ABT 737 |
Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines | |
6837 | GSK 923295A |
Potent and selective centromere associated protein E (CENP-E) allosteric inhibitor | |
6838 | SGC 3027N |
Negative control for SGC 3027 (Cat. No. 6825) | |
6845 | RCM 1 |
FOXM1 inhibitor | |
6848 | GSK 2795039 |
NADPH oxidase 2 (NOX2) inhibitor | |
6850 | Thalidomide 4'-ether-alkylC2-amine |
Cereblon ligand with alkyl linker and terminal amine for onward chemistry | |
6851 | Pomalidomide 4'-alkylC2-amine |
Cereblon ligand with alkyl linker and terminal amine for onward chemistry | |
6852 | VH 032 amide-alkylC2-amine |
VHL ligand with alkyl linker and terminal amine for onward chemistry | |
6853 | VH 032 amide-alkylC6-amine |
VHL ligand with alkyl linker and terminal amine for onward chemistry | |
6854 | LY 3009120 |
Potent pan-Raf kinase inhibitor | |
6856 | α-Mangostin |
Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines | |
6857 | BAY 293 |
Potent KRas/SOS1 interaction inhibitor | |
6858 | MMG 11 |
TLR2 antagonist | |
6859 | FITM |
Potent and selective negative allosteric modulator of mGlu1 receptors | |
6860 | SB 290157 trifluoroacetate |
Potent C3a receptor antagonist | |
6861 | Anle138b |
Oligomeric aggregation inhibitor; inhibits prion protein and α-synuclein aggregate formation | |
6862 | Psoralen-triethylene glycol azide |
RNA conformation probe; reagent for COMRADES RNA platform | |
6863 | N6-Cyclohexyladenosine |
High affinity A1 receptor agonist | |
6865 | uPSEM 792 hydrochloride |
Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant | |
6866 | uPSEM 817 tartrate |
Highly potent and selective PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant | |
6867 | Rhein |
FTO (mRNA N6-methyladenine demethylase) inhibitor; also inhibits ALKBH2 and ALKBH3 | |
6868 | 8-Azaadenosine |
ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor; inhibits leukemia stem cell self-renewal | |
6870 | AZ 12799734 |
Potent TGF-βRI inhibitor | |
6871 | MO-I-500 |
FTO inhibitor; anticonvulsant | |
6872 | BQCA |
Positive allosteric modulator of M1 receptors | |
6873 | DC 271 |
Fluorescent retinoic acid analog; solvochromatic probe | |
6874 | AMG 333 |
Potent and selective TRPM8 antagonist; active in vivo | |
6875 | TRPC6-PAM-C20 |
Selective positive allosteric modulator (PAM) of TRPC6 | |
6877 | VU 0134992 |
Kir4.1 blocker | |
6878 | BMS 466442 |
Potent and selective inhibitor of asc-1 | |
6879 | VH 032 amide-PEG1-amine |
VHL ligand with PEG linker and terminal amine for onward chemistry | |
6880 | VH 032 amide-alkylC10-amine |
VHL ligand with alkyl linker and terminal amine for onward chemistry | |
6881 | SB 4 |
Potent BMP4 agonist | |
6882 | DiFMUP |
Fluorescent phosphatase substrate | |
6884 | TC SL C5 |
Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor | |
6885 | PU 23 |
Multidrug resistance protein (MRP) 4 inhibitor | |
6886 | ML 67-33 |
K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) channel activator | |
6887 | ML 335 |
Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator | |
6888 | ML 402 |
Selective TREK channel activator | |
6889 | ML 418 |
Kir 7.1 inhibitor; also inhibits Kir 6.2 | |
6890 | VH 032 amide-alkylC8-amine |
VHL ligand with alkyl linker and terminal amine for onward chemistry | |
6891 | PND 1186 |
Potent FAK inhibitor; orally bioavailable | |
6892 | RIPGBM |
RIPK2 modulator; pro-drug of cRIPGM; orally bioavailable and brain penetrant | |
6893 | VU 6005649 |
Positive allosteric modulator of mGlu7 and mGlu8 receptors; also NK1 antagonist; brain penetrant | |
6895 | VU 0424465 |
Potent mGlu5 positive allosteric modulator and agonist; binds allosteric site with high affinity | |
6896 | Dynapyrazole A |
Hedgehog signaling inhibitor; dynein inhibitor | |
6897 | P110 |
Dynamin-related protein 1 (Drp1) inhibitor; cell-permeable | |
6898 | Mitochondrial fusion promoter M1 |
Mitochondrial fusion promoter | |
6899 | TH 257 |
Potent and selective allosteric LIMK 1/2 inhibitor |