All Products

Displaying Products by Catalog Number (6800 - 6899)

Cat. No. Product Name / Activity
6801 Tocriscreen Epigenetics Library
A library of 101 epigenetic compounds (250 μL, 10 mM DMSO solutions)
6802 6 TMR Tre
Fluorescent trehalose; selectively labels mycobacterial cell envelope
6803 MRK 740
Potent PRDM9 inhibitor
6806 AZ 3451
Potent negative allosteric modulator of PAR2 receptors
6807 NNC 0640
Negative allosteric modulator of glucagon and GLP-1 receptors
6809 L-DON
Glutaminase inhibitor; also inhibits other glutamine-using enzymes and transporters
6811 Lapatinib
Potent and selective dual ErbB2 (HER-2) and EGFR inhibitor
6812 Afatinib dimaleate
Potent dual specificity EGFR/HER2 inhibitor; active in vivo
6813 Ibrutinib
Potent and selective BTK inhibitor
6814 Sorafenib
Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and cKIT
6815 Selumetinib
Potent and selective MEK inhibitor; orally bioavailable
6816 Sitagliptin phosphate
Potent and selective DPP IV inhibitor
6817 BAY 8002
Potent dual MCT1/2 inhibitor; orally bioavailable
6818 Artemether
Antimalarial; also inhibits neuroinflammation
6819 Mefloquine hydrochloride
Cx36 and Cx50 gap channel blocker; also antimalarial and antischistosomal
6821 ZAP 180013
Zap70 inhibitor; inhibits interaction with ITAMs
6823 CycLuc 1
Synthetic luciferase substrate; brain penetrant; displays NIR emission
6825 SGC 3027
Potent and selective PRMT7 inhibitor
6826 AZ 1729
FFA2 allosteric agonist; displays bias for the Gi signaling pathway
6827 Artesunate
Suppresses ROS-induced activation of the NLRP3 inflammasome; antimalarial
6829 (R)-Shikonin
PTEN inhibitor; induces necroptosis; anti-inflammatory
6830 Conivaptan hydrochloride
Very high affinity vasopressin V1A and V2 antagonist; orally bioavailable
6831 TRPV3 74a
Selective TRPV3 antagonist; brain penetrant
6832 Ec2la
Positive allosteric modulator of CB2 receptors; active in vivo
6833 RO 5263397 hydrochloride
Potent TA1 receptor agonist
6834 Auxin
Chemical dimerizer used in auxin-inducible degron (AID) system; phytohormone
6835 ABT 737
Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines
6837 GSK 923295A
Potent and selective centromere associated protein E (CENP-E) allosteric inhibitor
6838 SGC 3027N
Negative control for SGC 3027 (Cat. No. 6825)
6840 AD 01
FKBPL (FK506-binding protein like)-based peptide; inhibits breast cancer stem cell self-renewal; also antiangiogenic
6845 RCM 1
FOXM1 inhibitor
6847 TAT-GluA2 3Y
Inhibitor of AMPA receptor endocytosis
6850 Thalidomide 4'-ether-alkylC2-amine
Cereblon ligand with alkyl linker and terminal amine for onward chemistry
6851 Pomalidomide 4'-alkylC2-amine
Cereblon ligand with alkyl linker and terminal amine for onward chemistry
6852 VH 032 amide-alkylC2-amine
VHL ligand with alkyl linker and terminal amine for onward chemistry
6853 VH 032 amide-alkylC6-amine
VHL ligand with alkyl linker and terminal amine for onward chemistry
6854 LY 3009120
Potent pan-Raf kinase inhibitor
6856 α-Mangostin
Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines
6857 BAY 293
Potent KRas/SOS1 interaction inhibitor
6858 MMG 11
TLR2 antagonist
6859 FITM
Potent and selective negative allosteric modulator of mGlu1 receptors
6860 SB 290157 trifluoroacetate
Potent C3a receptor antagonist
6861 Anle138b
Oligomeric aggregation inhibitor; inhibits prion protein and α-synuclein aggregate formation
6863 N6-Cyclohexyladenosine
High affinity A1 receptor agonist
6864 Ticagrelor
High affinity and reversible P2Y12 antagonist; displays inverse agonism in vitro; also inhibits ENT1
6865 uPSEM 792 hydrochloride
Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant
6866 uPSEM 817 tartrate
Highly potent and selective PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant
6867 Rhein
FTO (mRNA N6-methyladenine demethylase) inhibitor; also inhibits ALKBH2 and ALKBH3
6868 8-Azaadenosine
ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor; inhibits leukemia stem cell self-renewal
6870 AZ 12799734
Potent TGF-βRI inhibitor
6872 BQCA
Positive allosteric modulator of M1 receptors
6874 AMG 333
Potent and selective TRPM8 antagonist; active in vivo
6875 TRPC6-PAM-C20
Selective TRPC6 positive allosteric modulator
6877 VU 0134992
Kir4.1 blocker
6879 VH 032 amide-PEG1-amine
VHL ligand with PEG linker and terminal amine for onward chemistry
6880 VH 032 amide-alkylC10-amine
VHL ligand with alkyl linker and terminal amine for onward chemistry
6881 SB 4
Potent BMP4 agonist
6882 DiFMUP
Fluorescent phosphatase substrate
6884 TC SL C5
Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor
6885 PU 23
Multidrug resistance protein (MRP) 4 inhibitor
6886 ML 67-33
K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) channel activator
6887 ML 335
Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator
6888 ML 402
Selective TREK channel activator
6889 ML 418
Kir 7.1 inhibitor; also inhibits Kir 6.2
6890 VH 032 amide-alkylC8-amine
VHL ligand with alkyl linker and terminal amine for onward chemistry
6891 PND 1186
Potent FAK inhibitor; orally bioavailable
6892 RIPGBM
RIPK2 modulator; pro-drug of cRIPGM; orally bioavailable and brain penetrant
6893 VU 6005649
Positive allosteric modulators of mGlu7 and mGlu8 receptors; also NK1 antagonist; brain penetrant
6895 VU 0424465
Potent mGlu5 positive allosteric modulator and agonist; binds allosteric site with high affinity
6896 Dynapyrazole A
Hedgehog signaling inhibitor; dynein inhibitor
6897 P110
Dynamin-related protein 1 (Drp1) inhibitor; cell-permeable
6898 Mitochondrial fusion promoter M1
Mitochondrial fusion promoter
6899 TH 257
Potent and selective allosteric LIMK 1/2 inhibitor

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