You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
SB 290157 trifluoroacetate New
Potent C3a receptor antagonist (IC50 values are 27 - 30 nM for C3a-induced Ca2+ mobilization in vitro and ex vivo). Inhibits C3a-induced chemotaxis in human mast cell line. Also inhibits tau hyperphosphorylation in vitro. Displays anti-inflammatory effects in animal models of airway inflammation and arthritis. Also inhibits glucose-induced insulin secretion and ATP production from ex vivo human and mouse pancreatic islets.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 526.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.9 mL||9.5 mL||18.99 mL|
|5 mM||0.38 mL||1.9 mL||3.8 mL|
|10 mM||0.19 mL||0.95 mL||1.9 mL|
|50 mM||0.04 mL||0.19 mL||0.38 mL|
References are publications that support the biological activity of the product.
Ames et al (2001) Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models. J.Immunol. 166 6341 PMID: 11342658
Atanes et al (2018) C3aR and C5aR1 act as key regulators of human and mouse β-cell function. Cell Mol.Life Sci. 75 715 PMID: 28921001
Hu et al (2019) Complement C3a receptor antagonist attenuates tau hyperphosphorylation via glycogen synthase kinase 3β signaling pathways. Eur.J.Pharmacol. 850 135 PMID: 30771350
If you know of a relevant reference for SB 290157 trifluoroacetate, please let us know.
View Related Products by Product Action
Keywords: SB 290157 trifluoroacetate, SB 290157 trifluoroacetate supplier, SB290157, trifluoroacetate, complement, system, receptor, C3a, antagonists, antagonism, antiinflammatory, chemotaxis, Complement, 6860, Tocris Bioscience
Citations for SB 290157 trifluoroacetate
Citations are publications that use Tocris products.
Currently there are no citations for SB 290157 trifluoroacetate. Do you know of a great paper that uses SB 290157 trifluoroacetate from Tocris? Please let us know.
Reviews for SB 290157 trifluoroacetate
There are currently no reviews for this product. Be the first to review SB 290157 trifluoroacetate and earn rewards!
Have you used SB 290157 trifluoroacetate?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.