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Dynein inhibitor. Inhibits dynein 1 and dynein 2-dependent microtubule gliding (IC50 values are 2.3 and 2.6 μM, respectively). Inhibits hedgehog signaling in vitro (IC50 = 1.9 μM). Displays reversible inhibition of retrograde and anterograde intraflagellar transport in Chlamydomonas; displays stronger inhibition of retrograde transport.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 486.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||10.27 mL||51.37 mL||102.73 mL|
|1 mM||2.05 mL||10.27 mL||20.55 mL|
|2 mM||1.03 mL||5.14 mL||10.27 mL|
|10 mM||0.21 mL||1.03 mL||2.05 mL|
References are publications that support the biological activity of the product.
Steinman et al (2017) Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action. Elife 6 e25174 PMID: 28524820
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Keywords: Dynapyrazole A, Dynapyrazole A supplier, dynein, inhibitors, inhibits, hedgehog, signaling, flagellar, transport, retrograde, anterograde, Hedgehog, Signaling, 6896, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.