Home / Pharmacology / Enzymes / Kinases / Bruton's Tyrosine Kinase / Bruton's Tyrosine Kinase Inhibitors / Ibrutinib

Ibrutinib

Cat. No. 6813 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective BTK inhibitor
Chemical Name: 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Ibrutinib

Ibrutinib is a potent and selective BTK inhibitor (IC50= 0.5 nM). Selective for BTK against a screening panel of kinase enzymes. Inhibits autophosphorylation of BTK, phosphorylation of PLCγ, and phosphorylation of ERK (IC50 of 11 nM, 29 nM and 13 nM, respectively). Also inhibits ErbB4 (IC50 = 0.25-3.4 nM). Induces cytotoxicity of chronic lymphocytic leukemia (CLL) cells. Reduces clinical arthritis scores in a mouse model.

Compound Libraries for Ibrutinib

Ibrutinib is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Epigenetics Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Ibrutinib

M. Wt 440.5
Formula C25H24N6O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 936563-96-1
PubChem ID 24821094
InChI Key XYFPWWZEPKGCCK-GOSISDBHSA-N
Smiles NC1=C2C(N([C@@H]3CCCN(C(C=C)=O)C3)N=C2C4=CC=C(C=C4)OC5=CC=CC=C5)=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ibrutinib

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.05 100

Preparing Stock Solutions for Ibrutinib

The following data is based on the product molecular weight 440.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.35 mL 22.7 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.14 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for Ibrutinib

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for Ibrutinib

References are publications that support the biological activity of the product.

Honigberg et al (2010) The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc.Natl.Acad.Sci.USA 107 13075 PMID: 20615965

Pan et al (2007) Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase. Chem.Med.Chem. 2 58 PMID: 17154430

Estupiñán et al (2021) Comparative analysis of BTK inhibitors and mechanisms underlying adverse effects. Front.Cell Dev.Biol. 9 630942 PMID: 33777941

If you know of a relevant reference for Ibrutinib, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Bruton's Tyrosine Kinase Inhibitors

Keywords: Ibrutinib, Ibrutinib supplier, Potent, and, selective, Bruton, tyrosine, kinase, inhibitor, Btk, Brutons, Tyrosine, Kinase, (BTK), EGFR, 6813, Tocris Bioscience

1 Citation for Ibrutinib

Citations are publications that use Tocris products. Selected citations for Ibrutinib include:

John E et al (2021) Ibrutinib as a potential therapeutic for cocaine use disorder. Transl Psychiatry 11 623 PMID: 34880215

Do you know of a great paper that uses Ibrutinib from Tocris? Please let us know.

Reviews for Ibrutinib

There are currently no reviews for this product. Be the first to review Ibrutinib and earn rewards!

Have you used Ibrutinib?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review