MMG 11

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Cat.No. 6858 - MMG 11 | C15H14O7 | CAS No. 313254-94-3
Description: TLR2 antagonist
Chemical Name: Ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Pathways (1)

Biological Activity

TLR2 antagonist (IC50 values are in the range 1.7 - 5.7 μM). Exhibits selectivity for TLR2 over TLR4, TLR5, TLR7/8 and TLR9. Reduces TLR2-mediated cytokine secretion from PBMCs.

Technical Data

M. Wt 306.27
Formula C15H14O7
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 313254-94-3
PubChem ID 854609
InChI Key IIDUJWIVMGALOG-UHFFFAOYSA-N
Smiles CCOC(=O)C1=CC=C(CC(=O)C2=C(O)C(O)=C(O)C=C2)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.63 100
ethanol 15.31 50

Preparing Stock Solutions

The following data is based on the product molecular weight 306.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.27 mL 16.33 mL 32.65 mL
5 mM 0.65 mL 3.27 mL 6.53 mL
10 mM 0.33 mL 1.63 mL 3.27 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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References

References are publications that support the biological activity of the product.

Grabowski et al (2019) Identification of a pyrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening. Biochem.Pharmacol. 154 148 PMID: 29684378


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Citations for MMG 11

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Literature in this Area

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Pathways for MMG 11

Toll-like Receptor

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.