Sitagliptin phosphate

Pricing Availability   Qty
Description: Potent and selective DPP IV inhibitor
Chemical Name: (3R)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone phosphate
Purity: ≥98% (HPLC)

Biological Activity for Sitagliptin phosphate

Sitagliptin phosphate is a potent and selective DPP IV (DPP4) inhibitor (IC50 = 18 nM). Displays >2600-fold selectivity for DPP IV over other proline specific peptidases. Reduces blood glucose and increases GLP-1 levels after oral glucose tolerance test in normal and diet-induced obese mice.

Compound Libraries for Sitagliptin phosphate

Sitagliptin phosphate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Sitagliptin phosphate

M. Wt 505.31
Formula C16H15F6N5O.H3O4P
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 654671-78-0
PubChem ID 6451150
Smiles OP(O)(O)=O.N[C@H](CC1=C(C=C(C(F)=C1)F)F)CC(N2CCN3C(C2)=NN=C3C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Sitagliptin phosphate

Solvent Max Conc. mg/mL Max Conc. mM
water 25.27 50
DMSO 25.27 50

Preparing Stock Solutions for Sitagliptin phosphate

The following data is based on the product molecular weight 505.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.96 mL 19.79 mL 39.58 mL
2.5 mM 0.79 mL 3.96 mL 7.92 mL
5 mM 0.4 mL 1.98 mL 3.96 mL
25 mM 0.08 mL 0.4 mL 0.79 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Sitagliptin phosphate

References for Sitagliptin phosphate

References are publications that support the biological activity of the product.

Kim et al (2005) (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-α]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J.Med.Chem. 48 141 PMID: 15634008

If you know of a relevant reference for Sitagliptin phosphate, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Dipeptidyl Peptidase IV Inhibitors

Keywords: Sitagliptin phosphate, Sitagliptin phosphate supplier, DPPIV, DPP4, inhibitors, inhibits, potent, selective, CD26, Dipeptidyl, Peptidase, IV, (DPP-IV), 6816, Tocris Bioscience

Citations for Sitagliptin phosphate

Citations are publications that use Tocris products.

Currently there are no citations for Sitagliptin phosphate. Do you know of a great paper that uses Sitagliptin phosphate from Tocris? Please let us know.

Reviews for Sitagliptin phosphate

There are currently no reviews for this product. Be the first to review Sitagliptin phosphate and earn rewards!

Have you used Sitagliptin phosphate?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review