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TC SL C5
Biological Activity for TC SL C5
TC SL C5 is a metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor (KD = 2.9 μM). Binds Malat1 3' terminal stability element for nuclear expression (ENE) triplex. Reduces Malat1 RNA levels by 54% and branching morphogenesis by 38% in mammary tumor organoids. Modulates Malat1 downstream genes without affecting Neat1.
Compound Libraries for TC SL C5
Technical Data for TC SL C5
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TC SL C5
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for TC SL C5
The following data is based on the product molecular weight 323.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.09 mL||15.46 mL||30.92 mL|
|5 mM||0.62 mL||3.09 mL||6.18 mL|
|10 mM||0.31 mL||1.55 mL||3.09 mL|
|50 mM||0.06 mL||0.31 mL||0.62 mL|
References for TC SL C5
References are publications that support the biological activity of the product.
Abulwerdi et al (2019) Selective small-molecule targeting of a triple helix encoded by the long noncoding RNA, MALAT1. ACS Chem.Biol. 14 223 PMID: 30620551
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Keywords: TC SL C5, TC SL C5 supplier, TCSLC5, MALAT1, Metastasis-associated, lung, adenocarcinoma, transcript, 1, RNA, inhibitors, inhibits, breast, cancer, element, for, nuclear, expression, ENE, triplex, DNA,, and, Protein, Synthesis, 6884, Tocris Bioscience
Citations for TC SL C5
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Literature in this Area
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