TRPC6-PAM-C20

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Cat.No. 6875 - TRPC6-PAM-C20 | C22H21NO4 | CAS No. 667427-75-0
Description: Selective TRPC6 positive allosteric modulator
Chemical Name: 3-(3-,4-Dihydro-6,7-dimethoxy-3,3-dimethyl-1-isoquinolinyl)-2H-1-benzopyran-2-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Selective TRPC6 positive allosteric modulator. Selectively activates TRPC6 over other TRP channels. Also activates TRPA1. Induces transient increase in intracellular Ca2+ in HEK cells expressing TRPC6 (EC50 = 2.37 μM). Potentiates OAG (1-oleoyl-1-acetyl-sn-glycerol)-induced Ca2+ influx in human platelets, and enhances OAG-induced platelet aggregation.

Technical Data

M. Wt 363.41
Formula C22H21NO4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 667427-75-0
PubChem ID 1081484
InChI Key SNICUMZYPOCXCO-UHFFFAOYSA-N
Smiles COC1=C(OC)C=C2C(CC(C)(C)N=C2C2=CC3=CC=CC=C3OC2=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.34 100
ethanol 7.27 20

Preparing Stock Solutions

The following data is based on the product molecular weight 363.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.75 mL 13.76 mL 27.52 mL
5 mM 0.55 mL 2.75 mL 5.5 mL
10 mM 0.28 mL 1.38 mL 2.75 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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References

References are publications that support the biological activity of the product.

Häfner et al (2019) Discovery and characterization of a positive allosteric modulator of transient receptor potential canonical 6 (TRPC6) channels. Cell Calcium 78 26 PMID: 30594060


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Keywords: TRPC6-PAM-C20, TRPC6-PAM-C20 supplier, Transient, receptor, potential, canonical, TRPC6, positive, allosteric, modulators, modulates, PAM, platelet, aggregation, TRPC, 6875, Tocris Bioscience

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