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Cat.No. 6875 - TRPC6-PAM-C20 | C22H21NO4 | CAS No. 667427-75-0
Description: Selective positive allosteric modulator (PAM) of TRPC6
Chemical Name: 3-(3-,4-Dihydro-6,7-dimethoxy-3,3-dimethyl-1-isoquinolinyl)-2H-1-benzopyran-2-one
Purity: ≥98% (HPLC)

Biological Activity for TRPC6-PAM-C20

TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator. Selectively activates TRPC6 over other TRP channels. Also activates TRPA1. Induces transient increase in intracellular Ca2+ in HEK cells expressing TRPC6 (EC50 = 2.37 μM). Potentiates OAG (1-oleoyl-1-acetyl-sn-glycerol)-induced Ca2+ influx in human platelets, and enhances OAG-induced platelet aggregation.

Technical Data for TRPC6-PAM-C20

M. Wt 363.41
Formula C22H21NO4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 667427-75-0
PubChem ID 1081484
Smiles COC1=C(OC)C=C2C(CC(C)(C)N=C2C2=CC3=CC=CC=C3OC2=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TRPC6-PAM-C20

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 36.34 100
ethanol 7.27 20

Preparing Stock Solutions for TRPC6-PAM-C20

The following data is based on the product molecular weight 363.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.75 mL 13.76 mL 27.52 mL
5 mM 0.55 mL 2.75 mL 5.5 mL
10 mM 0.28 mL 1.38 mL 2.75 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets for TRPC6-PAM-C20

References for TRPC6-PAM-C20

References are publications that support the biological activity of the product.

Häfner et al (2019) Discovery and characterization of a positive allosteric modulator of transient receptor potential canonical 6 (TRPC6) channels. Cell Calcium 78 26 PMID: 30594060

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Citations for TRPC6-PAM-C20

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