Welcome to Tocris Bioscience

The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for June

Potent and reversible NIMA related kinase 2 (Nek2) inhibitor
5150 | NCL 00017509

IC50 = 56 nM. Induces increased mitotic abnormalities and mitotic delay. Cell permeable and active in vivo.

Related Products: JH 295 TCS ERK 11e rac-CCT 250863
Potent and selective PFKFB3 inhibitor
5675 | AZ PFKFB3 26

IC50 = 0.023 μM. Selective for PFKFB3 over PFKFB2 and PFKFB1 isoforms (IC50 values are 0.382 μM and 2.06 μM, respectively). Reduces levels of fructose-1,6-bisphosphate in A549 cells (IC50 = 0.343 μM). Exhibits no significant inhibition of other kinases.

Related Products: 3PO PFK 15 AZ PFKFB3 67
Serine/threonine protein kinase 16 (STK16) inhibitor
6036 | STK16-IN-1

IC50 = 295 nM. Reduces cell number and increases accumulation of binucleated MCF-1 cells. Enhances cell apoptosis in combination with chemotherapeutics. Also inhibits P1 3-Kδ and P1 3-Kγ kinases (IC50 values are 856 and 867 nM, respectively) and mTOR kinase (IC50= 5.56 μM).

Related Products: LY 294002 AZD 6482 AZD 3147
Potent Ack1/TNK2 inhibitor
6061 | XMD 8-87

IC50 = 38 and 113 nM in Ba/F3 cell lines containing leukemia-associated D163E and R806Q mutations, respectively. Blocks phosphorylation of TNK2 receptors containing solid-tumor type truncation mutations.

Related Products: AIM 100 ASP 3026 GNF 7
Plasminogen activator inhibitor-1 (PAI-1) inhibitor
6194 | TM 5441

IC50 = 3.58 - 60.3 μM. Increases apoptosis in human cancer cell lines. Reduces senescence and increases lifespan in mouse models of ageing (kl/kl). Inhibits L-NAME (Cat.No. 0665) induced systolic blood pressure increases, telomere length reduction and hypertrophy in mice. Renoprotective. Orally bioavailable.

Related Products: Azilsartan Tiplaxtinin TM 5275

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Careers at Tocris

Careers at Tocris

Tocris Bioscience currently has opportunities for a Product Manager.

If you would like to be considered for any positions not currently advertised, we welcome your speculative application.

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Bio-Techne Events

26th ISN-ESN Biennal Meeting

26th ISN-ESN Biennial Meeting

August 20 - 24, 2017

Paris , France

Booth: 11