Welcome to Tocris Bioscience
The leading supplier of high performance life science reagents
Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.
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IC50 = 56 nM. Induces increased mitotic abnormalities and mitotic delay. Cell permeable and active in vivo.Related Products: JH 295 TCS ERK 11e rac-CCT 250863
IC50 = 0.023 μM. Selective for PFKFB3 over PFKFB2 and PFKFB1 isoforms (IC50 values are 0.382 μM and 2.06 μM, respectively). Reduces levels of fructose-1,6-bisphosphate in A549 cells (IC50 = 0.343 μM). Exhibits no significant inhibition of other kinases.Related Products: 3PO PFK 15 AZ PFKFB3 67
IC50 = 295 nM. Reduces cell number and increases accumulation of binucleated MCF-1 cells. Enhances cell apoptosis in combination with chemotherapeutics. Also inhibits P1 3-Kδ and P1 3-Kγ kinases (IC50 values are 856 and 867 nM, respectively) and mTOR kinase (IC50= 5.56 μM).Related Products: LY 294002 AZD 6482 AZD 3147
IC50 = 38 and 113 nM in Ba/F3 cell lines containing leukemia-associated D163E and R806Q mutations, respectively. Blocks phosphorylation of TNK2 receptors containing solid-tumor type truncation mutations.Related Products: AIM 100 ASP 3026 GNF 7
IC50 = 3.58 - 60.3 μM. Increases apoptosis in human cancer cell lines. Reduces senescence and increases lifespan in mouse models of ageing (kl/kl). Inhibits L-NAME (Cat.No. 0665) induced systolic blood pressure increases, telomere length reduction and hypertrophy in mice. Renoprotective. Orally bioavailable.Related Products: Azilsartan Tiplaxtinin TM 5275
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August 20 - 24, 2017
Paris , France