Welcome to Tocris Bioscience

The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for July

Selective p300 histone acetyltransferase (HAT) inhibitor
5103 | Lys-CoA

IC50 = 50-500 nM. Exhibits approximately 100-fold selectivity for p300 over PCAF (IC50 = 200 μM). Inhibits p300-dependent transcription. Active in vivo.

Related Products: Anacardic acid C 646 EML 425
Monocarboxylate transporter (MCT1) inhibitor
5658 | AR-C 141990

pKi = 7.6. Exhibits approximately 10-fold selectivity for MCT1 over MCT2 and no significant activity against MCT3 or 4. Inhibits graft versus host response and prolongs cardiac graft survival in a rat model. Immunosuppressant. Also inhibits brain penetration of GHB analog HOCPCA.

Related Products: UK 5099 AR-C155858 SR 13800
Potent and selective Brk inhibitor
6073 | P21d

IC50 = 30 nM. Exhibits >650-fold selectively for Brk over Aurora B kinase and Lck. Downregulates SNAIL protein, restores E-cadherin expression and suppresses migration in breast cancer cells. Also active in vivo and orally bioavailable.

Related Products: Bosutinib KB SRC 4 Tilfrinib
Potent and selective SAM-competitive EZH2 inhibitor
6128 | GSK 343

IC50 = 4 mM. Exhibits >60 fold selectivity for EZH2 over EZH1 and a range of other methyltransferases. Inhibits proliferation of prostate cancer cell lines in vitro.

Related Products: 3-Deazaneplanocin A UNC 1999 PF 06726304
Potent apelin (APJ) receptor agonist
6293 | ELA-14 (human)

Ki = 0.93 nM. ELABELA analog. Activates Gαil pathway and β-arrestin-2 recruitment . Reduces arterial pressure in rat hearts. Active in vivo. ELA-14 negative control (Cat.No. 6294) available.

Related Products: [Pyr1]-Apelin-13 Apelin-36 (human) ELA-14 negative control

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Careers at Tocris

Careers at Tocris

Tocris Bioscience currently has opportunities for a Product Manager.

If you would like to be considered for any positions not currently advertised, we welcome your speculative application.

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Bio-Techne Events

SENC 2017

17th National Congress of the Spanish Society of Neuroscience

September 27 - 30, 2017

Alicante, Spain