Welcome to Tocris Bioscience
The leading supplier of high performance life science reagents
Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.
New for March
Rapidly and efficiently releases glutamate (Cat. No. 0218) when photolysed (350 - 365 nm excitation). Water soluble and stable at neutral pH, and pharmacologically inactive at neuronal glutamate receptors (up to 200 μM). 5.5 times more photosensitive than MNI-caged L-glutamate (Cat. No. 1490). Laser activation of MDNI-glu evokes a rapid increase in intracellular Ca2+ concentration in astrocytes.Related Products: L-Glutamic acid MNI-caged-L-glutamate RuBi-Glutamate
IC50 = 4 nM. Selective for PRMT5 over a panel of other PRMTs and lysine methyltransferases. Inhibits proliferation of mantle cell lymphoma (MCL) in vitro.Related Products: UNC 2327 Furamidine MS 023
IC50 = 1 nM. Attenuates oxaliplatin-induced NF-κB activation, increases oxaliplatin cytotoxicity, and potentiates oxaliplatin-induced apoptosis in AIPC cells. Reduces the numbers of infiltrating neutrophils into both in vitro and in vivo tumor models. Orally bioavailable.Related Products: SB 265610 SB 225002 NVP CXCR2 20
Selectively traces exocytosis in dopaminergic neuronal cell culture and brain tissue. Excitation and emission maxima are 352 and 451 nm, respectively.Related Products: Tetrabenazine Reserpine FFN 206
IC50 = 0.7 nM. Inhibits proliferation of Karpas-422 cells (non-Hodgkin's lymphoma) in vitro, halts tumor growth and reduces intratumoral H3K27Me3 levels in mice.Related Products: 3-Deazaneplanocin A UNC 1999 UNC 0642
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