Welcome to Tocris Bioscience
The leading supplier of high performance life science reagents
Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.
New for May
IC50 = 6 nM. Inhibits the formation of autophagosomes in lung cancer cells.Related Products: BX 795 Amlexanox MRT 67307
IC50 = 15 nM. Exhibits >100-fold selectivity for SMYD2 over 25 other methyltransferases including SMYD3, SUV420H1 and SUV420H2. Also exhibits selectivity over a panel of GPCRs, nuclear receptors and cytochrome P450 enzymes. Inhibits SMYD2-mediated p53 methylation in vitro. Also inhibits proliferation of a range of esophageal, liver and breast cancer cell lines.Related Products: 3-Deazaneplanocin A A 366 (S)-PFI 2
EC50 = 3.9 nM. Delays onset and reduces severity of symptoms in mice with experimental autoimmune encephalomyelitis (EAE). Also suppresses NF-κB signaling. Brain penetrant and orally bioavailable.Related Products: Ro 106-9920 Withaferin A Bengamide B
Ki = 92 nM. Exhibits selectivity for CHT over dopamine, serotonin and noradrenaline transporters; acetylcholinesterase and cholineacetyltransferase; and a panel of 65 other GPCRs, ion channels and transporters.Related Products: (±)-Vesamicol Indatraline Bupropion
EC50 = 194 nM. Induces chemotaxis in CXCR4-expressing cells in vitro. Mobilizes polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) from bone marrow niche in vivo. Exhibits biased signaling towards Gi proteins over G13 and β-arrestin.Related Products: AMD 3100 octahydrochloride VUF 11207 CTCE 9908
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June 22 - 25, 2016
San Franscisco, CA, USA