Welcome to Tocris Bioscience

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Potent and reversible NIMA related kinase 2 (Nek2) inhibitor

5150 | NCL 00017509

IC₅₀ = 56 nM. Induces increased mitotic abnormalities and mitotic delay. Cell permeable and active in vivo.

Potent and selective PFKFB3 inhibitor

5675 | AZ PFKFB3 26

IC₅₀ = 0.023 μM. Selective for PFKFB3 over PFKFB2 and PFKFB1 isoforms (IC₅₀ values are 0.382 μM and 2.06 μM, respectively). Reduces levels of fructose-1,6-bisphosphate in A549 cells (IC₅₀ = 0.343 μM). Exhibits no significant inhibition of other kinases.

Serine/threonine protein kinase 16 (STK16) inhibitor

6036 | STK16-IN-1

IC₅₀ = 295 nM. Reduces cell number and increases accumulation of binucleated MCF-1 cells. Enhances cell apoptosis in combination with chemotherapeutics. Also inhibits P1 3-Kδ and P1 3-Kγ kinases (IC₅₀ values are 856 and 867 nM, respectively) and mTOR kinase (IC₅₀= 5.56 μM).

Potent Ack1/TNK2 inhibitor

6061 | XMD 8-87

IC₅₀ = 38 and 113 nM in Ba/F3 cell lines containing leukemia-associated D163E and R806Q mutations, respectively. Blocks phosphorylation of TNK2 receptors containing solid-tumor type truncation mutations.

Plasminogen activator inhibitor-1 (PAI-1) inhibitor

6194 | TM 5441

IC₅₀ = 3.58 - 60.3 μM. Increases apoptosis in human cancer cell lines. Reduces senescence and increases lifespan in mouse models of ageing (kl/kl). Inhibits L-NAME (Cat.No. 0665) induced systolic blood pressure increases, telomere length reduction and hypertrophy in mice. Renoprotective. Orally bioavailable.

Quick Order

Find multiple products by catalog number

Careers at Tocris

Tocris Bioscience currently has opportunities for a Product Manager.

If you would like to be considered for any positions not currently advertised, we welcome your speculative application.

Bio-Techne Events

26th ISN-ESN Biennial Meeting

August 20 - 24, 2017

Paris , France

Booth: 11