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The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for January

Potent BRD9/7 inhibitor
6000 | TP 472

Kd values are 33 and 340 nM, respectively. Exhibits >30-fold selectivity for BRD9 over other bromodomains except BRD7. Cell permeable and active in vivo

Related Products: (+)-JQ1 I-BET 151 I-BRD9
Raf kinase and VEGFR-2 inhibitor
6015 | RAF 265

Inhibits c-Raf, wild type B-Raf and mutant B-Raf (V600E). Cytotoxic in certain melanoma cells lines. Effects enhanced by protein kinase D3 inhibition, preventing reactivation of MAPK signaling and increasing caspase activity. Orally bioavailable.

Related Products: SU 5416 SU 5402 GDC 0879
Endogenous amylin, calcitonin, CGRP and adrenomedullin agonist
6030 | Amylin (rat)

pEC50 values are 7.06-9.50 at hCTa, 8.11 at rCTa, 7.73-10.1 at hAMY1a, 9.74 at rAMY1a, 7.92 at hAMY1b, 7.78-9.9 at hAMY2a, 7.94 at hAMY2b, 8.09-10.8 at hAMY3a, 9.97 at rAMY and 8.19 at hAMY3b receptors. Suppresses insulin-stimulated glucose uptake. Delays gastric emptying and promotes satiety. Active in vivo.

Related Products: CGRP (rat) AC 187 Pramlintide
Potent soluble guanylyl cyclase (sGC) activator
6052 | BAY 58-2667

EC50 = 6.4 nM. Binds heme-free sGC. Exhibits antihypertensive effects in vivo.

Related Products: YC 1 BAY 41-2272 BAY 41-8543
Oct4 activator; enhances iPSC reprogramming efficiency
6066 | OAC-2

Enhances iPSC reprogramming four-fold and accelerates the appearance of iPSC colonies in combination with 4F (Oct4, Sox2, c-Myc and Klf4). Also induces cardiomyocyte-like cells from human fibroblasts, as part of the 9C cocktail (CHIR 99021, A83-01, BIX 01294, AS83541, SC1, Y-27632, SU 16f, JNJ10198409 and OAC-2)

Related Products: Y-27632 CHIR 99021 O4I1

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Tocris Exclusively Licenses LDN 193189

Tocris Acquires Exclusive License for LDN 193189

Tocris acquires exclusive license to supply LDN 193189 commercially to the research community.

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