Welcome to Tocris Bioscience

The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for April

High affinity pan-RAR antagonist
5758 | AGN 193109

Kd values are 2, 2 and 3 nM at RARα, RARβ and RARγ, respectively. Does not bind retinoic X receptors.

Related Products: Retinoic acid BMS 493 ER 50891
Potent DDHD2 inhibitor
5865 | KLH 45

IC50 = 1.3 nM. Selective for DDHD2 over 40 other serine hydrolases, but does exhibit cross-reactivity with ABHD6. In vivo active. Increases brain triacylglycerol levels in mice.

Related Products: A 922500 WWL 123 JNJ DGAT2-A
Inhibitor of IL-1β post-translational processing
6107 | CP 424174

IC50 = 210 nM. Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.

Related Products: Z-VAD-FMK AS 2444697 CRID3 sodium salt
Photoactivatable cell permeable fluorescent dye
6149 | PA Janelia Fluor™ 549, SE

Supplied as NHS ester. Non-fluorescent until activated at 365 nm. Photochemical quantum yield of uncaging = 2.2%, with improved yield upon protein conjugation. Compatible with self-labeling tag systems. Suitable for single molecule tracking and super resolution microscopy in live cells. Can be multiplexed with PA Janelia Fluor™ 646, SE (Cat. No. 6150) to perform two-colour sptPALM in live cells. Cell permeable. Excitation maximum = 551 - 553 nm; emission maximum = 570 - 573 nm.

Related Products: Hoechst 33342 Sulforhodamine 101 Janelia Fluor™ 549, SE
Potent and selective VCP allosteric inhibitor
6180 | NMS 873

IC50 = 30 nM. Selective over all other AAA ATPases, HSP90 and kinases tested (IC50 >10 nM). Activates the unfolded protein response (UPR), and modulates autophagosome maturation. Exhibits antiproliferative activity in cancer cells in vitro. Reduces VCP-sensitaisation to trypsin digestion.

Related Products: Xanthohumol GSK 2606414 Azoramide

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Tocris Announces Collaboration

Tocris Announces Collaboration with Chemical Probes Portal

Tocris is listed as trusted vendor on the Chemical Probes Portal, a free web resource providing recommendations on the best chemical reagents.

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