Welcome to Tocris Bioscience

The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for October

Potent Nek2 inhibitor
4546 | rac-CCT 250863

IC50 = 73 nM. Exhibits selectivity for Nek2 over PLK1, MPS1, Cdk2 and Aurora A.

Related Products: Wortmannin Kenpaullone TC-S 7010
Negative allosteric modulator at mGlu7; brain penetrant
5715 | (±)-ADX 71743

IC50 = 300 nM. Blocks high frequency-induced LTP at SC-CA1 synapses in hippocampal slices in vitro. Increases evoked excitatory postsynaptic currents (eEPSCs) in mice. Brain penetrant.

Related Products: MPEP AMN 082 XAP 044
Potent TMEM16A (Anoctamin-1) blocker
5770 | MONNA

IC50 = 80 nM. Exhibits >100-fold selectivity for TMEM16A over bestrophin-1, CLC2 and CFTR. Induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.

Related Products: CFTRinh 172 T16Ainh - A01 GlyH 101
Selective noradrenalin and dopamine fluorescent indicator
5905 | Neurosensor 521

Exhibits selectivity over adrenalin, glycine and glutamate. Enables visualization of noradrenalin and dopamine in fixed and live cells. Excitation wavelength 488 nm, emission 521 nm.

Related Products: FFN 511 Methoxy-X04 FFN 102
Selective myeloperoxidase (MPO) inhibitor
6004 | PF 06281355

IC50 = 1.5 μM in LPS-stimulated human whole blood. Selective for MPO over a panel of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. Inhibits MPO activity in peritoneal lavage and plasma in a murine peritonitis model. Also reduces lung edema in a murine pulmonary immune complex vasculitis model. Orally bioavailable.

Related Products: Zileuton 680C91 Apocynin

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