Welcome to Tocris Bioscience

The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for February

Potent and selective S1P1 receptor antagonist
5833 | Ex 26

IC50 = 0.93 nM. Exhibits >3,000-fold selectivity for S1P1 over S1P2, S1P3, S1P4 and S1P5. Induces lymphocyte sequestration in peripheral lymph nodes and upregulates S1P1 receptor expression. Reduces disease severity in mice with EAE. Increases IFN-α production in stimulated dendritic cells in vivo.

Related Products: Sphingosine-1-phosphate VPC 23019 TY 52156
Potent mTOR inhibitor
5955 | eCF 309

IC50 = 15 nM. Exhibits >60-fold selectivity for mTOR over PI 3-kinases and is inactive against a panel of other kinases. Inhibits growth of ER-positive MCF7 breast cancer cells in vitro (EC50 = 8.5 nM). Cell permeable.

Related Products: Rapamycin Torin 1 AZD 3147
Potent PAK4 inhibitor; orally available
6005 | PF 3758309

IC50 = 1.3 nM; Kd = 2.7 nM. Inhibits proliferation and anchorage-independent growth of a panel of tumor cell lines in vitro. Suppresses growth of human HCT116 and A549 tumor cell xenografts in mice.

Related Products: IPA 3 PIR 3.5 FRAX 486
Potent glucokinase activator; orally bioavailable
6034 | AM 2394

EC50 = 60 nM. Reduces plasma glucose levels in an oral glucose tolerance test in ob/ob mice.

Related Products: GKA 50 LDN 193188 TC-G 1005
Ketamine metabolite; lacks ketamine side effects
6094 | 2R,6R-Hydroxynorketamine

Enhances AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices. Decreases intracellular D-serine (a NMDA co-agonist) concentrations in PC-12 cells (IC50 = 0.68 nM). Exerts antidepressant effects in mice.

Related Products: (R)-Norketamine 2S,6S-Hydroxynorketamine (S)-Norketamine

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Tocris Announces Collaboration

Tocris Announces Collaboration with Chemical Probes Portal

Tocris is listed as trusted vendor on the Chemical Probes Portal, a free web resource providing recommendations on the best chemical reagents.

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