Welcome to Tocris Bioscience
The leading supplier of high performance life science reagents
Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.
New for July
IC50 = 50-500 nM. Exhibits approximately 100-fold selectivity for p300 over PCAF (IC50 = 200 μM). Inhibits p300-dependent transcription. Active in vivo.Related Products: Anacardic acid C 646 EML 425
pKi = 7.6. Exhibits approximately 10-fold selectivity for MCT1 over MCT2 and no significant activity against MCT3 or 4. Inhibits graft versus host response and prolongs cardiac graft survival in a rat model. Immunosuppressant. Also inhibits brain penetration of GHB analog HOCPCA.Related Products: UK 5099 AR-C155858 SR 13800
IC50 = 30 nM. Exhibits >650-fold selectively for Brk over Aurora B kinase and Lck. Downregulates SNAIL protein, restores E-cadherin expression and suppresses migration in breast cancer cells. Also active in vivo and orally bioavailable.Related Products: Bosutinib KB SRC 4 Tilfrinib
IC50 = 4 mM. Exhibits >60 fold selectivity for EZH2 over EZH1 and a range of other methyltransferases. Inhibits proliferation of prostate cancer cell lines in vitro.Related Products: 3-Deazaneplanocin A UNC 1999 PF 06726304
Ki = 0.93 nM. ELABELA analog. Activates Gαil pathway and β-arrestin-2 recruitment . Reduces arterial pressure in rat hearts. Active in vivo. ELA-14 negative control (Cat.No. 6294) available.Related Products: [Pyr1]-Apelin-13 Apelin-36 (human) ELA-14 negative control
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