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The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for May

α4β2 nAChR potent positive allosteric modulator
5963 | CMPI

EC50 values are 20 and 18 nM for rat and human, respectively. Selective for hα4β2 over hα3β2, hα3β4 and hα7. Inhibits (α4)2(β2)3, muscle-type and Torpedo nAChRs (IC50 values are 0.5, 0.7 and 0.2 μM, respectively), but not (α4)3(β2)2 receptors. Exhibits ability to photoincorporate into aliphatic and nucleophilic amino acid side chains.

Related Products: Desformylflustrabromine LY 2087101 NS 9283
Potent bone morphogenetic protein type I (ALK) inhibitor
6151 | LDN 212854

IC50 values are 1.3, 2.4, 85.8, 2,133 and 9,276 nM for ALK2, ALK1, ALK3, ALK4 and ALK5, respectively. Exhibits selectivity for ALK2 over ALK4 and ALK5 in cellular assays. Inhibits heterotopic ossification in a mutant ALK2 mouse model of fibrodysplasia ossificans progressiva. Also exhibits activity against RIPK2, ABL1 and PDGFR-β (IC50 values < 100 nM).

Related Products: A 83-01 Dorsomorphin DMH-1
PROTAC that selectively degrades BRD4 in cells
6154 | MZ 1

Cell penetrant Proteolysis Targeting Chimera (PROTAC) compound based on (+)-JQ1 (Cat.No. 4499), conjugated to a von Hippel-Lindau (VHL) ligand. Retains high affinity for BRD2, BRD3 and BRD4 bromodomains (Kd = 13-60 nM) but induces preferential degradation of BRD4 over BRD2 and BRD3 in cells at 10-100 nM concentrations. Exhibits potent cytotoxicity and profound antiproliferative effects in AML cell lines. Negative control cis MZ 1 also available.

Related Products: I-BET 151 (+)-JQ1 cis MZ 1
High-affinity inhibitor of E3 ubiquitin ligase VHL
6156 | VH 298

Kd = 80-90 nM. Blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation, initiating hypoxic response. Results in time and concentration-dependent accumulation of hydroxylated HIF-α, and upregulates mRNA and protein levels of HIF target genes. Cell permeable. Negative control cis VH 298 also available.

Related Products: SZL P1-41 Heclin cis VH 298
Potent Na+/Ca2+ exchanger (NCX) inhibitor
6164 | SEA 0400

Inhibits NCX activity in canine cardiac sarcolemmal vesicles, rat cardiomyocytes, cultured neurons, astrocytes and microglia (IC50 values are 90, 92, 33, 5 and 8.3 nM, respectively). Reduces infarct volumes and exhibits protective effects against myocardial ischemia in rats.

Related Products: SN-6 Benzamil ITH 12575

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Janelia Fluor™ Dyes Available from Tocris

Tocris Introduces New Fluorescent Dyes Range

Tocris has introduced a range of Janelia Fluor™ dyes for advanced imaging techniques. Developed at the Janelia Research Campus and licensed by Tocris from HHMI these fluorescent dyes are bright and photostable. Image courtesy of the Janelia Archive.

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