Welcome to Tocris Bioscience
The leading supplier of high performance life science reagents
Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.
New for June
Ki = 3 nM. Exhibits >2500-fold selectivity for EP4 over EP2 and EP3. Also selective over a range of other prostanoid receptors, ion channels, transporters and enzymes. Inhibits PGE2-induced vasodilation of middle cerebral and meningeal arteries in vitro, and carotid blood flow in vivo. Orally bioavailable.Related Products: L-161,982 ONO AE3 208 TCS 2510
Ki =12 nM. Exhibits >100-fold less activity at other related proteases including trypsin, pancreatic elastase, collagenase and murine macrophage elastase. Inhibits NA-induced lung hemorrhaging and suppresses leukocyte levels in an in vivo model of COPD. Orally active.Related Products: SSR 69071 Nafamostat Sivelestat sodium salt
Promotes Oct3/4 expression and stabilizes the Oct3/4 protein in HEK293 cells. Induces expression of the pluripotent-associated genes Lin28, Sox2 and Nanog, and suppresses Rex1. Induces a 15-fold increase in Oct3/4 expression in human primary fibroblasts.Related Products: Thiazovivin 3-Deazaneplanocin A OAC-1
IC50 = 990 nM; Ki = 610 nM. Exhibits selectivity for LSD1 over MAO-B and MAO-A (Ki values are 17 and 110 μM, respectively).Related Products: Tranylcypromine RN 1 GSK LSD 1
IC50 values are 0.007, 0.1, 3.5 and 5 μM for β, δ, γ and α isoforms, respectively. Shows >1,000-fold selectively for PI 3-kinase β over a range of other kinases. Inhibits thrombus formation in animal models.Related Products: LY 294002 Wortmannin 3-Methyladenine
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