Welcome to Tocris Bioscience

The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for June

High affinity and selective EP4 antagonist
5327 | BGC 20-1531

Ki = 3 nM. Exhibits >2500-fold selectivity for EP4 over EP2 and EP3. Also selective over a range of other prostanoid receptors, ion channels, transporters and enzymes. Inhibits PGE2-induced vasodilation of middle cerebral and meningeal arteries in vitro, and carotid blood flow in vivo. Orally bioavailable.

Related Products: L-161,982 ONO AE3 208 TCS 2510
High affinity and selective HNE1 inhibitor
5651 | ONO 6818

Ki =12 nM. Exhibits >100-fold less activity at other related proteases including trypsin, pancreatic elastase, collagenase and murine macrophage elastase. Inhibits NA-induced lung hemorrhaging and suppresses leukocyte levels in an in vivo model of COPD. Orally active.

Related Products: SSR 69071 Nafamostat Sivelestat sodium salt
Oct3/4 inducer
5664 | O4I2

Promotes Oct3/4 expression and stabilizes the Oct3/4 protein in HEK293 cells. Induces expression of the pluripotent-associated genes Lin28, Sox2 and Nanog, and suppresses Rex1. Induces a 15-fold increase in Oct3/4 expression in human primary fibroblasts.

Related Products: Thiazovivin 3-Deazaneplanocin A OAC-1
LSD1 inhibitor
5714 | S 2101

IC50 = 990 nM; Ki = 610 nM. Exhibits selectivity for LSD1 over MAO-B and MAO-A (Ki values are 17 and 110 μM, respectively).

Related Products: Tranylcypromine RN 1 GSK LSD 1
Potent and selective PI 3-kinase β inhibitor
5832 | TGX 221

IC50 values are 0.007, 0.1, 3.5 and 5 μM for β, δ, γ and α isoforms, respectively. Shows >1,000-fold selectively for PI 3-kinase β over a range of other kinases. Inhibits thrombus formation in animal models.

Related Products: LY 294002 Wortmannin 3-Methyladenine

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