Welcome to Tocris Bioscience

The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for December

Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist
5701 | AMG 853

IC50 values are 8 and 35 nM, respectively in plasma. Inhibits PGD2-induced down modulation of CRTH2 on CD16- granulocytes in human whole blood and PGD2-induced cAMP response in platelets. Inhibits PGD2-induced airway constriction in vivo. Orally bioavailable.

Related Products: Alprostadil BAY-u 3405 Treprostinil
Potent and selective PFKFB3 inhibitor
5742 | AZ PFKFB3 67

IC50 values are 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1 respectively.

Related Products: YZ9 3PO PFK 15
Potent LPA1 antagonist
5913 | Ro 6842262

IC50 = 25 nM. Exhibits >1,200-fold selectivity for LPA1 over LPA3. Attenuates NHLF human lung fibroblast cell proliferation and contraction in vitro. Also reduces LPA-induced histamine plasma levels in mice. Orally bioavailable.

Related Products: Sphingosine-1-phosphate H2L5186303 Ki 16425
Potent and selective PI 3-kinase p110δ inhibitor
5919 | PI 3065

IC50 = 5 nM; Ki = 1.5 nM. Exhibits >100-fold selectivity over p100α, p100γ and p100β isoforms (IC50 values are 600, 910, >10,000 nM, respectively). Attenuates 4TI tumor growth and metastasis in vivo.

Related Products: LY 294002 740 Y-P TGX 221
Potent δ-opioid receptor positive allosteric modulator
5983 | BMS 986187

EC50 = 30 nM. Exhibits 100-fold selectivity for δ over μ-opioid receptor. Enhances affinity of [Leu5]-Enkephalin (Cat.No. 1889), SNC 80 (Cat.No. 0764) and TAN 67 (Cat.No. 0921) for the δ-opioid receptor.

Related Products: SNC 80 SB 205607 [Leu5]-Enkephalin

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Tocris Announces Collaboration with Chemical Probes Portal

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