Welcome to Tocris Bioscience
The leading supplier of high performance life science reagents
Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.
New for August
IC50 values are 0.5-2, 19 and 41 nM, respectively. Also weak inhibitor of FLT1 and Src. Inhibits EGFR and ErbB2 autophosphorylation in vitro in NSCLC and T-47D breast cancer cell lines, respectively. Inhibits tumor growth of EGFR-overexpressing A431 and ErbB2 overexpressing BT-474 tumor xenografts in mice.Related Products: AG 1478 Iressa Bosutinib
IC50 = 17 nM. Displays antiplatelet and antithrombotic activity in vivo. Orally available.Related Products: (+)-Clopidogrel hydrogen sulfate AR-C 66096 PSB 0739
IC50 values are 8, 8, 30, 83 and 119 nM for PRMT6, PRMT8, PRMT1, PRMT4 and PRMT3, respectively. Exhibits no significant activity against type II and III PRMTs, PKMTs, DNMTs, KDMs and reader proteins. Reduces global arginine asymmetric dimethylation levels in vitro.Related Products: 3-Deazaneplanocin A Furamidine SGC 707
IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively. Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters. Reduces growth of TDO-expressing P815 mastocytoma tumors in mice. Orally bioavailable.Related Products: 680C91 DMXAA 1-Methyl-D-tryptophan
PIC50 values are 16.5 and 1080 nM for human and rat mPGES-1, respectively. Exhibits >6500-fold selectivity for mPGES-1 over COX-1 and COX-2. Inhibits IL-1β-induced PGE2 synthesis in vitro.Related Products: Alprostadil HQL 79 TFC 007
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