Welcome to Tocris Bioscience

The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for March

Stable photoreleaser of L-glutamate
5785 | MDNI-caged-L-glutamate

Rapidly and efficiently releases glutamate (Cat. No. 0218) when photolysed (350 - 365 nm excitation). Water soluble and stable at neutral pH, and pharmacologically inactive at neuronal glutamate receptors (up to 200 μM). 5.5 times more photosensitive than MNI-caged L-glutamate (Cat. No. 1490). Laser activation of MDNI-glu evokes a rapid increase in intracellular Ca2+ concentration in astrocytes.

Related Products: L-Glutamic acid MNI-caged-L-glutamate RuBi-Glutamate
Potent and selective PRMT5 inhibitor
5777 | GSK 591

IC50 = 4 nM. Selective for PRMT5 over a panel of other PRMTs and lysine methyltransferases. Inhibits proliferation of mantle cell lymphoma (MCL) in vitro.

Related Products: UNC 2327 Furamidine MS 023
Potent CXCR2 antagonist
5872 | AZ 10397767

IC50 = 1 nM. Attenuates oxaliplatin-induced NF-κB activation, increases oxaliplatin cytotoxicity, and potentiates oxaliplatin-induced apoptosis in AIPC cells. Reduces the numbers of infiltrating neutrophils into both in vitro and in vivo tumor models. Orally bioavailable.

Related Products: SB 265610 SB 225002 NVP CXCR2 20
Selective fluorescent VMAT2 substrate
5911 | FFN 200

Selectively traces exocytosis in dopaminergic neuronal cell culture and brain tissue. Excitation and emission maxima are 352 and 451 nm, respectively.

Related Products: Tetrabenazine Reserpine FFN 206
Highly potent and SAM-competitive EZH2 inhibitor
6169 | PF 06726304

IC50 = 0.7 nM. Inhibits proliferation of Karpas-422 cells (non-Hodgkin's lymphoma) in vitro, halts tumor growth and reduces intratumoral H3K27Me3 levels in mice.

Related Products: 3-Deazaneplanocin A UNC 1999 UNC 0642

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Careers at Tocris

Careers at Tocris

Tocris Bioscience currently has opportunities for a Synthetic Organic Chemist and a Technical Writer.

If you would like to be considered for any positions not currently advertised, we welcome your speculative application.

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