Welcome to Tocris Bioscience

The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for May

Potent Chk2 inhibitor
4968 | CCT 241533

IC50 = 3 nM. Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes.

Related Products: SB 218078 TCS 2312 AZD 7762
High affinity and selective CB2 inverse agonist
5039 | SR 144528

Ki = 0.6 nM. Exhibits >700-fold selectivity for CB2 over CB1 receptors. Blocks the effects of CP 55,940 (Cat. No. 0949) on forskolin-sensitive adenylyl cyclase activity and MAPK in CHO cells expressing CB2 receptors. Also blocks CP 55,940-induced B-cell activation. Orally bioavailable.

Related Products: AM 630 JWH 133HU 308
Potent and selective CXCR2 antagonist
5660 | NVP CXCR2 20

IC50 = 40 nM. Exhibits selectivity for CXCR2 over a panel of 49 other GPCRs. Orally bioavailable.

Related Products: SB 225002 (±)-NBI 74330 CTCE 9908
Potent and selective GPR139 agonist
5666 | JNJ 63533054

EC50 = 16 nM. Selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142. Brain and cell penetrant. Orally bioavailable.

Related Products: TC-O 9311 TC-G 1008 Prosaptide TX14(A)
Selective CBP/p300 bromodomain inhibitor
5801 | PF CBP1

IC50 values are 125 and 363 nM for CBP and p300, respectively. Exhibits >100-fold selectivity for CBP over BRD4. Also exhibits selectivity over a panel of other bromodomains. Reduces LPS-induced IL-1β, IL-6 and IFN-β expression in macrophages in vitro. Also downregulates RGS4 expression in primary cortical neurons in vitro.

Related Products: I-BET 151 I-CBP 112 GSK 2801

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