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The leading supplier of high performance life science reagents
Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.
New for December
IC50 values are 8 and 35 nM, respectively in plasma. Inhibits PGD2-induced down modulation of CRTH2 on CD16- granulocytes in human whole blood and PGD2-induced cAMP response in platelets. Inhibits PGD2-induced airway constriction in vivo. Orally bioavailable.Related Products: Alprostadil BAY-u 3405 Treprostinil
IC50 values are 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1 respectively.Related Products: YZ9 3PO PFK 15
IC50 = 25 nM. Exhibits >1,200-fold selectivity for LPA1 over LPA3. Attenuates NHLF human lung fibroblast cell proliferation and contraction in vitro. Also reduces LPA-induced histamine plasma levels in mice. Orally bioavailable.Related Products: Sphingosine-1-phosphate H2L5186303 Ki 16425
IC50 = 5 nM; Ki = 1.5 nM. Exhibits >100-fold selectivity over p100α, p100γ and p100β isoforms (IC50 values are 600, 910, >10,000 nM, respectively). Attenuates 4TI tumor growth and metastasis in vivo.Related Products: LY 294002 740 Y-P TGX 221
EC50 = 30 nM. Exhibits 100-fold selectivity for δ over μ-opioid receptor. Enhances affinity of [Leu5]-Enkephalin (Cat.No. 1889), SNC 80 (Cat.No. 0764) and TAN 67 (Cat.No. 0921) for the δ-opioid receptor.Related Products: SNC 80 SB 205607 [Leu5]-Enkephalin
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