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The leading supplier of high performance life science reagents
Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.
New for July
Kd values are 14 and 239 nM, respectively. Exhibits selectivity for BRD9/7 over 48 other bromodomains, 324 kinases and 55 GPCRs. Inhibits proliferation of AML cell lines in vitro and reduces AML tumor xenograft growth in vivo. Cell permeable and orally active.Related Products: (+)-JQ1 I-BET 151 PFI 4
Kd = 6 μM. Suppresses LPS-induced iNOS and nitric oxide expression in macrophages. Anti-inflammatory.Related Products: Curcumin CDDO Im Oltipraz
EC50 values are 4.1 and 5.7 nM in cAMP and GTPγS assays, respectively. Exhibits 60-fold selectivity over S1P1, and >1,600-fold selectivity over S1P2-4 and a panel of 129 kinases and 79 receptors. Improves blood-brain barrier integrity in vitro and reverses age-related cognitive decline in vivo. Orally available.Related Products: Sphingosine-1-phosphate JTE 013 TY 52156
IC50 values are 1 and 3 nM, respectively. Exhibits >100-fold selectivity for TNKS1/2 over PARP-1, PARP-2 and PARP-6. Inhibits Wnt signaling in DLD-1 cells (IC50 = 5 nM). Exhibits moderate oral bioavailability.Related Products: JW 55 XAV 939 IWP 4
IC50 values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively. Binds to closed/inactive channel. Selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Increases latency of tail and paw withdrawal in mouse tail-flick and paw-flick tests. Analgesic.Related Products: Amiloride APETx2 Psalmotoxin 1
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July 29 - 31, 2016