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The leading supplier of high performance life science reagents
Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.
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KB = 434 nM. Exhibits >10,000-fold selectivity for P2Y14 over other P2Y receptors. Inhibits UDP-glucose and MRS 2690-induced porcine pancreatic artery contraction ex vivo. Also blocks UDP-glucose-induced chemotaxis of HL-60 leukemia cells in vitro.Related Products: MRS 2690 MRS 2500 AR-C 118925XX
Ki = 120-190 nM. Displays >60-fold selectivity for mIDH1 (found in ~75% of gliomas) over wild type IDH1. Also inhibits D-2-hydroxyglutaric acid in cells expressing mIDH1 (EC50 = 2.4 μM). Does not display cytotoxicity towards non-cancerous human cells. Phenotypically lethal.Related Products: LM 10 1-Methyl-D-tryptophan 680C91
IC50 values are 6, 9 and 230 nM for cdk1, cdk2 and cdk4, respectively. Inhibits proliferation of HCT-116 colon cancer cells in vitro.Related Products: Ro 3306 Senexin A CGP 60474
IC50 values are 4.1 and 70 nM for αvβ3 and αvβ5, respectively. Exhibits ~10-fold selectivity over gpIIb/IIIa. Increases endothelial monolayer permeability. Also exhibits antiangiogenic activity.Related Products: BIO 1211 TC-I 15 BIO 5192
IC50 values are 3, 4.7, 6.6, 8.4, 12, 26 and 26 nM for MMP-13, MMP-2, MMP-1, ADAM 17, MMP-9, MMP-7 and MMP-14, respectively. Suppresses TNF-α production in an acute LPS-mouse model. Reduces severity score in an in vivo model of rheumatoid arthritis. Displays selective cytotoxicity towards tumor cells and cancer stem cells in vitro. Induces tumor apoptosis in a breast cancer in vivo model. Orally bioavailable.Related Products: WAY 170523 GM 6001 GI 254023X
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