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The Tocris molarity calculator is a useful tool which allows you to calculate the:
The Tocris molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol)
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Tocris Bioscience has been supporting scientists since 1982! Our catalog comprises over 4500 gold standard and cutting-edge tools, covering many research areas including cancer, cardiovascular, endocrinology, immunology, pain and inflammation, respiratory system , stem cells and cell and gene therapy.
Our portfolio includes high purity GPCR agonists, antagonists, PAMs, NAMs and biased agonists, as well as enzyme inhibitors, ion channel modulators and fluorescent probes and dyes.
We always strive to be the first to market, making the latest research tools commercially available. One of the latest editions to the catalog is our chemogenetic range, which includes highly potent DREADD ligands and PSEMs. These tools allow for interrogation of neuronal activity in vivo. Read more about the technique and tools available in our Chemogenetics Research Bulletin.
Targeted Protein Degradation (TPD) involves the use of heterobifunctional small molecule "degraders" (e.g. PROTACs®) to knockdown target proteins within cells. Each degrader consists of binding moieties for an Ubiquitin E3 Ligases , and a target protein joined by a linker. As the degrader binds, a ternary complex forms between the target protein and E3 ligase, leading to polyubiquitination of the target protein. This allows the proteasome to detect the protein and subsequently degrade it.
View a short animation explaining degrader technology on the dTAG platform.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.