The Tocris molarity calculator is a useful tool which allows you to calculate the:
The Tocris molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol)
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Tocris Bioscience has been supporting scientists since 1982! Our catalog comprises over 4500 gold standard and cutting-edge tools, covering many research areas including cancer, cardiovascular, endocrinology, immunology, pain and inflammation, respiratory system , stem cells and cell and gene therapy.
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Targeted Protein Degradation (TPD) involves the use of heterobifunctional small molecule "degraders" (e.g. PROTACs®) to knockdown target proteins within cells. Each degrader consists of binding moieties for an Ubiquitin E3 Ligases , and a target protein joined by a linker. As the degrader binds, a ternary complex forms between the target protein and E3 ligase, leading to polyubiquitination of the target protein. This allows the proteasome to detect the protein and subsequently degrade it.
View a short animation explaining degrader technology on the dTAG platform.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.