RO 5263397 hydrochloride

Pricing Availability   Qty
Cat.No. 6833 - RO 5263397 hydrochloride | C10H11FN2O.HCl
Description: Potent TA1 receptor agonist
Chemical Name: (4S)-4-(3-Fluoro-2-methylphenyl)-4,5-dihydro-2-oxazolamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (5)

Biological Activity

Potent trace amine 1 (TA1) receptor agonist (EC50 values are 0.12, 35 and 17-85 nM for mouse, rat and human receptors, respectively). Increases wakefulness and reduces REM and NREM sleep duration in wild type mice. Inhibits spontaneous locomotor activity in dopamine transport (DAT) knockout mice.

Technical Data

M. Wt 230.67
Formula C10H11FN2O.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
InChI Key JFAYMXKBMDRFHY-SBSPUUFOSA-N
Smiles CC1=C([C@H]2COC(N)=N2)C=CC=C1F.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.07 100
water 23.07 100

Preparing Stock Solutions

The following data is based on the product molecular weight 230.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.34 mL 21.68 mL 43.35 mL
5 mM 0.87 mL 4.34 mL 8.67 mL
10 mM 0.43 mL 2.17 mL 4.34 mL
50 mM 0.09 mL 0.43 mL 0.87 mL

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References

References are publications that support the biological activity of the product.

Espinoza et al (2018) Biochemical and functional characterization of the trace amine-associated receptor 1 (TAAR1) agonist RO5263397. Front.Pharmacol. 9 645 PMID: 29977204

Galley et al (2015) Discovery and characterization of 2-aminooxazolines as highly potent, selective, and orally active TAAR1 agonists. ACS.Med.Chem.Letts. 7 192 PMID: 26985297

Schwartz et al (2017) Trace amine-associated receptor 1 regulates wakefulness and EEG spectral composition. Neuropsychopharmacology. 42 1305 PMID: 27658486


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Citations for RO 5263397 hydrochloride

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