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Biological Activity for ABT 737
ABT 737 is a high affinity Bcl-2 family inhibitor (Ki ≤ 1nM for Bcl-XL, Bcl-2 and Bcl-w). BH3 mimetic; triggers Bax/Bak-mediated apoptosis. Exhibits cytotoxicity in lymphoma cell lines overexpressing bcl-2 (EC50 < 1 μM) and multiple myeloma cells (IC50 = 5-15 μM). Induces apoptosis in patient-derived CLL cells. Promotes regression of SCLC tumors in a mouse xenograft model. Synergizes with certain other anticancer agents.
Technical Data for ABT 737
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ABT 737
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for ABT 737
The following data is based on the product molecular weight 813.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.23 mL||6.15 mL||12.29 mL|
|5 mM||0.25 mL||1.23 mL||2.46 mL|
|10 mM||0.12 mL||0.61 mL||1.23 mL|
|50 mM||0.02 mL||0.12 mL||0.25 mL|
References for ABT 737
References are publications that support the biological activity of the product.
Oltersdorf et al (2005) An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 425 677 PMID: 15902208
van Delft, MF et al (2006) The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell. 10 389 PMID: 17097561
Kline et al (2007) ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells. Leukemia 21 1549 PMID: 17460700
If you know of a relevant reference for ABT 737, please let us know.
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1 Citation for ABT 737
Citations are publications that use Tocris products. Selected citations for ABT 737 include:
Jerome et al (2022) Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer's disease. Cell Metab 34 1248-1263.e6 PMID: 35987203
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Literature in this Area
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