ABT 737

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Cat.No. 6835 - ABT 737 | C42H45ClN6O5S2 | CAS No. 852808-04-9
Description: Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines
Chemical Name: 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)
Pathways (1)

Biological Activity

High affinity Bcl-2 family inhibitor (Ki ≤ 1nM for Bcl-XL, Bcl-2 and Bcl-w). BH3 mimetic; triggers Bax/Bak-mediated apoptosis. Exhibits cytotoxicity in lymphoma cell lines overexpressing bcl-2 (EC50 < 1 μM) and multiple myeloma cells (IC50 = 5-15 μM). Induces apoptosis in patient-derived CLL cells. Promotes regression of SCLC tumors in a mouse xenograft model. Synergizes with certain other anticancer agents.

Technical Data

M. Wt 813.43
Formula C42H45ClN6O5S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 852808-04-9
PubChem ID 11228183
InChI Key HPLNQCPCUACXLM-PGUFJCEWSA-N
Smiles CN(CC[C@@H](NC1=C([N+]([O-])=O)C=C(S(=O)(NC(C2=CC=C(N3CCN(CC3)CC4=C(C5=CC=C(C=C5)Cl)C=CC=C4)C=C2)=O)=O)C=C1)CSC6=CC=CC=C6)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 81.34 100

Preparing Stock Solutions

The following data is based on the product molecular weight 813.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.23 mL 6.15 mL 12.29 mL
5 mM 0.25 mL 1.23 mL 2.46 mL
10 mM 0.12 mL 0.61 mL 1.23 mL
50 mM 0.02 mL 0.12 mL 0.25 mL

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References

References are publications that support the biological activity of the product.

Oltersdorf et al (2005) An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 425 677 PMID: 15902208

van Delft, MF et al (2006) The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell. 10 389 PMID: 17097561

Kline et al (2007) ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells. Leukemia 21 1549 PMID: 17460700


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Keywords: ABT 737, ABT 737 supplier, ABT737, bcl, family, bcl-2, bcl-w, bcl-xl, inhibitors, inhibits, BH3, mimetics, apoptosis, inducers, induces, Bcl-2, Family, 6835, Tocris Bioscience

Citations for ABT 737

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for ABT 737

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.