Conivaptan hydrochloride

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Cat.No. 6830 - Conivaptan hydrochloride | C32H26N4O2.HCl | CAS No. 168626-94-6
Description: Very high affinity vasopressin V1A and V2 antagonist; orally bioavailable
Chemical Name: N-[4-[(4,5-Dihydro-2-methylimidazo[4,5-d][benzazepin-6(1H)-yl)carbonyl]phenyl-[1,1'-biphenyl]-2-carboxamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Very high affinity vasopressin V1A and V2 antagonist (Ki values are 0.61 and 0.66 - 3.04 nM, respectively). Inhibits vasopressin-induced pressor responses in rats without altering blood pressure, and increases urine flow while decreasing urine osmolality. Orally bioavailable.

Technical Data

M. Wt 535.04
Formula C32H26N4O2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 168626-94-6
PubChem ID 151171
InChI Key IKENVDNFQMCRTR-UHFFFAOYSA-N
Smiles CC1=NC2=C(C3=CC=CC=C3N(C(C4=CC=C(C=C4)NC(C5=C(C6=CC=CC=C6)C=CC=C5)=O)=O)CC2)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.5 100
ethanol 10.7 20 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 535.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.87 mL 9.35 mL 18.69 mL
5 mM 0.37 mL 1.87 mL 3.74 mL
10 mM 0.19 mL 0.93 mL 1.87 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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References

References are publications that support the biological activity of the product.

Tahara et al (1997) Pharmacological profile of YM087, a novel potent nonpeptide vasopressin V1A and V2 receptor antagonist, in vitro and in vivo. J.Pharmacol.Exp.Ther. 282 301 PMID: 9223568

Yatsu et al (1997) Pharmacological profile of YM087, a novel nonpeptide dual vasopressin V1A and V2 receptor antagonist, in dogs. Eur.J.Pharmacol. 321 225 PMID: 9063692


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Citations for Conivaptan hydrochloride

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