Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewConivaptan hydrochloride
Description: Very high affinity vasopressin V1A and V2 antagonist; orally bioavailable
Chemical Name: N-[4-[(4,5-Dihydro-2-methylimidazo[4,5-d][benzazepin-6(1H)-yl)carbonyl]phenyl-[1,1'-biphenyl]-2-carboxamide hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Conivaptan hydrochloride
Conivaptan hydrochloride is a very high affinity vasopressin V1A and V2 antagonist (Ki values are 0.61 and 0.66 - 3.04 nM, respectively). Inhibits vasopressin-induced pressor responses in rats without altering blood pressure, and increases urine flow while decreasing urine osmolality. Orally bioavailable.
Compound Libraries for Conivaptan hydrochloride
Conivaptan hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Conivaptan hydrochloride
| M. Wt | 535.04 |
| Formula | C32H26N4O2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 168626-94-6 |
| PubChem ID | 151171 |
| InChI Key | IKENVDNFQMCRTR-UHFFFAOYSA-N |
| Smiles | CC1=NC2=C(C3=CC=CC=C3N(C(C4=CC=C(C=C4)NC(C5=C(C6=CC=CC=C6)C=CC=C5)=O)=O)CC2)N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Conivaptan hydrochloride
References for Conivaptan hydrochloride
References are publications that support the biological activity of the product.
Tahara et al (1997) Pharmacological profile of YM087, a novel potent nonpeptide vasopressin V1A and V2 receptor antagonist, in vitro and in vivo. J.Pharmacol.Exp.Ther. 282 301 PMID: 9223568
Yatsu et al (1997) Pharmacological profile of YM087, a novel nonpeptide dual vasopressin V1A and V2 receptor antagonist, in dogs. Eur.J.Pharmacol. 321 225 PMID: 9063692
View Related Products by Target
View Related Products by Product Action
Keywords: Conivaptan hydrochloride, Conivaptan hydrochloride supplier, conivaptan, HCl, very, high, affinity, vasopressin, V1A, V2, antagonists, antagonism, AVP, orally, bioavailable, Vasopressin, Receptors, 6830, Tocris Bioscience
Citations for Conivaptan hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for Conivaptan hydrochloride.
Reviews for Conivaptan hydrochloride
There are currently no reviews for this product. Be the first to review Conivaptan hydrochloride and earn rewards!
Have you used Conivaptan hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.