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Description: FTO inhibitor; anticonvulsant
Chemical Name: N-[5-(4-Chlorophenyl)-3,4-dihydroxy-2-furanyl]ethanesulfonamide
Purity: ≥98% (HPLC)

Biological Activity for MO-I-500

MO-I-500 is a FTO inhibitor (IC50 = 8.7 μM for purified FTO in vitro), which increases N6-methyladenosine (m6A) levels in total cellular mRNA in HeLa cells. MO-I-500 modulates levels of specific miRNAs. In a triple-negative breast cancer cell line metabolically challenged by culture without glutamine (SUM149-MA cells), MO-I-500 inhibits cell proliferation. MO-I-500 also displays anticonvulsant activity in a 6 Hz mouse model of epilepsy at nontoxic doses.

Compound Libraries for MO-I-500

MO-I-500 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for MO-I-500

M. Wt 317.75
Formula C12H12ClNO5S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1585219-04-0
PubChem ID 73505416
Smiles CCS(=O)(NC1=C(C(O)=C(C2=CC=C(C=C2)Cl)O1)O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MO-I-500

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 31.77 100

Preparing Stock Solutions for MO-I-500

The following data is based on the product molecular weight 317.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.15 mL 15.74 mL 31.47 mL
5 mM 0.63 mL 3.15 mL 6.29 mL
10 mM 0.31 mL 1.57 mL 3.15 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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References for MO-I-500

References are publications that support the biological activity of the product.

Zheng et al (2014) Synthesis of a FTO inhibitor with anticonvulsant activity. ACS.Chem.Neurosci. 5 658 PMID: 24834807

Singh et al (2016) Important role of FTO in the survival of rare panresistant triple-negative inflammatory breast cancer cells facing a severe metabolic challenge. PLoS One. 11 PMID: 27390851

If you know of a relevant reference for MO-I-500, please let us know.

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Keywords: MO-I-500, MO-I-500 supplier, FTO, inhibitors, inhibits, anticonvulsant, mRNA, N6-methyladenine, demethylase, α, alfa, alpha-ketoglutarate-dependent, dioxygenase, fat, mass, and, obesity-associated, protein, Other, Oxygenases/Oxidases, 6871, Tocris Bioscience

Citations for MO-I-500

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