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A selection of informative webinars & videos presented to you by Bio-Techne and Tocris Bioscience. Our webinars feature key opinion leaders in their respective fields and offer an engaging and educational insight into a variety of topics and research areas.
In this webinar Kristen Brennand describes how she and her team helped to pioneer a new approach to studying brain disease, establishing that genetic predisposition to psychiatric disorders can be modeled using patient-specific hiPSCs. In addition they use CRISPR-mediated genomic engineering strategies to study the impact of patient-specific variants across and between the cell types of the brain.Watch Now!
This webinar brings together experts to discuss chemical genomics and the advances and promises it brings to therapeutic discovery. The roadblocks and opportunities for protected open innovation in pharmaceutical R&D are examined, covering the use of compound libraries and the possibilities for drug repurposing, and the potential of patient lead approaches to identify novel targets with chemical genomics are considered.Watch Now!
Our short animation explains the dTAG system, which uses small molecule Degraders targeting a fusion protein comprising mutant FKBP12 and a target protein of interest, and harnesses the ubiquitin/proteasome system to selectively remove the fusion protein from cells. dTAG provides a useful alternative to genetic methods of target validation.Watch Now!
This webinar provides an introduction to the field of Targeted Protein Degradation, discussing design and optimization of Degrader molecules and how structural biology and rational design can shed light on the Degrader development process. The second section of the webinar presents the dTAG platform for target validation.Watch Now!
Our short animation explains the fundamentals of Targeted Protein Degradation (TPD) using small molecule Degraders. Degraders are heterobifunctional compounds that harness the ubiquitin/proteasome system to selectively remove proteins from cells.Watch Now!
Filmed in our state of the art chemistry facility in the UK, this short video provides a brief overview of the products and services available from Tocris for life science research, including small molecule and peptide agonists, antagonists and inhibitors for use in vivo and in vitro, as well as agents for fluorescence imaging.Watch Now!
Listen to a discussion by our panel of experts, Jean Stanton (J&J), John Tomtishen (Novartis), Dr. Sadik Kassim (Mustang Bio), and Dr. Diane Wotta (Bio-Techne), around what GMP really means in the context of raw materials and ancillary reagents; the quality of raw materials required along the commercialization pathway; when to start using GMP materials; and the current regulatory landscape. Find out more about Bio-techne's GMP Capabilities by visiting bio-techne.com.Watch Now!
Mechanical stress is important in the physiological functioning of many organs, and autophagy is known to be one of the major cell stress responses. In this webinar Dr Patrice Codogno discusses current perspectives and novel insights about the molecular events that regulate mammalian autophagosome biogenesis, and the role of autophagy in response to mechanical stress.Watch Now!
RAS proteins function as binary on-off switches that regulate diverse cytoplasmic signaling networks. In cancer and developmental disorders (RASopathies), mutationally activated RAS proteins drive aberrant signal transduction. This webinar discusses the vulnerabilities of RAS that have been exploited for the development of pharmacologic inhibitors of RAS function.Watch Now!