Welcome to the Tocris blog! If you’re looking for fresh insights into new tools for life science research, or are interested in the latest news and events from Tocris then you’re in the right place. Read on to discover our latest content.
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dTAG - A Protein Degradation Platform for Target Validation
What is dTAG?
dTAG (degradation TAG) is an innovative approach to target validation, using heterobifunctional small molecule Degraders to harness a cell’s protein degradation system and eliminate a...Read more
Applications for Epigenetic Chemical Probes in Non-Oncology Research
Epigenetic chemical probes are well established tools in oncology research but their application to other research fields is an area of emerging interest. This...Read more
Using Chemical Probes – A Brief Guide
With such a high level of discussion around the reproducibility of experiments described in the peer-reviewed literature, it is becoming increasingly prudent to scrutinize the tools that we use to conduct our research. Selecting a “good” probe is key to generating reliable and...Read more
Targeting the Immune System in Cancer with Small Molecules
Recent clinical successes in targeting the immune system for the treatment of cancer have harnessed biologicals, including antibodies, proteins, engineered cells and oncolytic viruses. Small molecules directed at the immune system offer advantages over...Read more
Five Reasons to use Small Molecules in Stem Cell Research
Stem cells are defined by their ability to differentiate into specialized cells and to self-renew. Pluripotent stem cells (PSCs), of which embryonic stem cells (ESCs) are an example, can differentiate into almost all cell...Read more
Small Molecules for Neural Induction of Stem Cells
Differentiation of human induced pluripotent stem cells (hiPSCs) into functional neurons is an exciting area of research, with considerable therapeutic potential in neurodegenerative diseases. In the past, conversion of...Read more
New Fluorescent Dyes for Super-resolution Microscopy
Fluorescence imaging is an essential tool in biological research, which enables the visualization of proteins in live and fixed cells. The resolution of images using conventional techniques, such...Read more