Scientific Reviews

A range of review articles written by leading experts

Tocris produces a range of short review articles written by leading experts summarizing the most recent developments in research and available products. We invite you to request or download your copy today.


5-HT Receptors Scientific Review

5-HT Receptors

Neuronal 5-HT Receptors and SERT

Nicholas M. Barnes and John F. Neumaier

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Autophagy Scientific Review

Autophagy

Molecular Mechanisms, Physiology & Pathology

Patricia Boya and Patrice Codogno

Written by Patricia Boya and Patrice Codogno, this review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.

Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands

Roger G Pertwee, University of Aberdeen

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.

Dopamine Receptors Scientific Review

Dopamine Receptors

Phillip G. Strange & Kim Neve

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Epigenetics Scientific Review

Epigenetics

Epigenetic Probes: Open Access Drug Discovery

Susanne Müller-Knapp and Peter J. Brown

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

GABA Receptors Scientific Review

GABA Receptors

Ian Martin, Norman Bowery & Susan Dunn

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Histamine Receptors Scientific Review

Histamine Receptors

Iwan de Esch and Rob Leurs, Vrije University

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.

MAPK Signaling Scientific Review

MAPK Signaling

MAP Kinase Pathways: Functions and Modulation

Aroon S. Karra and Melanie H. Cobb, University of Texas Southwestern Medical Center

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors

Francine C Acher, Université René Descartes-Paris V

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors

Susan Wonnacott, University of Bath

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors

Kenneth A. Jacobson, National Institutes of Health

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation

Sonia A. Tucci, Lynsay Kobelis and Tim C. Kirkham, University of Liverpool

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

RAS Oncoproteins Scientific Review

RAS Oncoproteins

Therapeutic Vulnerabilities

Kirsten L. Bryant, Adrienne D. Cox and Channing J. Der

Written by Kirsten L. Bryant, Adrienne D. Cox and Channing J. Der, this review provides a comprehensive overview of RAS protein function and RAS mutations in cancer. Key signaling pathways are highlighted and therapeutic vulnerabilities are explored. This review also includes a detailed section on RAS drug discovery and targeting synthetic lethal interactors of mutant RAS. Compounds available from Tocris are listed.

Retinoid Receptors Scientific Review

Retinoid Receptors

Pharmacology of Retinoid Receptors

Alexander R. Moise, University of Kansas

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.

Stem Cells Scientific Review

Stem Cells

Using Small Molecules to Control Stem Cell Growth and Differentiation

Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, Durham University

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.