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Description: Oligomeric aggregation inhibitor; inhibits prion protein and α-synuclein aggregate formation
Chemical Name: 3-(1,3-Benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole
Purity: ≥98% (HPLC)
Pathways (1)

Biological Activity for Anle138b

Anle138b is an oligomeric aggregation inhibitor that inhibits formation of pathological prion protein (PrPSc) and α-synuclein aggregates in vitro. Anle138b prevents accumulation of PrPSc in brain and spleen, and prolongs survival of prion-infected mice. Anle138b exhibits neuroprotective effects in a Parkinson's disease mouse model and improves motor performance in an α-synucleinopathy model. Orally bioavailable and brain penetrant.

Technical Data for Anle138b

M. Wt 343.18
Formula C16H11BrN2O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 882697-00-9
PubChem ID 44608289
Smiles BrC1=CC=CC(=C1)C1=CC(=NN1)C1=CC=C2OCOC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Anle138b

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 17.16 50

Preparing Stock Solutions for Anle138b

The following data is based on the product molecular weight 343.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.83 mL 29.14 mL 58.28 mL
2.5 mM 1.17 mL 5.83 mL 11.66 mL
5 mM 0.58 mL 2.91 mL 5.83 mL
25 mM 0.12 mL 0.58 mL 1.17 mL

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References for Anle138b

References are publications that support the biological activity of the product.

Wagner et al (2013) Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. Acta Neuropathol. 125 795 PMID: 23604588

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Citations for Anle138b

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Pathways for Anle138b

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.