Anle138b

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Cat.No. 6861 - Anle138b | C16H11BrN2O2 | CAS No. 882697-00-9
Description: Oligomeric aggregation inhibitor; inhibits prion protein and α-synuclein aggregate formation
Chemical Name: 3-(1,3-Benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Oligomeric aggregation inhibitor. Inhibits formation of pathological prion protein (PrPSc) and α-synuclein aggregates in vitro. Prevents accumulation of PrPSc in brain and spleen, and prolongs survival of prion-infected mice. Exhibits neuroprotective effects in a Parkinson's disease mouse model and improves motor performance in an α-synucleinopathy model. Orally bioavailable and brain penetrant.

Technical Data

M. Wt 343.18
Formula C16H11BrN2O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 882697-00-9
PubChem ID 44608289
InChI Key RCQIIBJSUWYYFU-UHFFFAOYSA-N
Smiles BrC1=CC=CC(=C1)C1=CC(=NN1)C1=CC=C2OCOC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.16 50

Preparing Stock Solutions

The following data is based on the product molecular weight 343.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.83 mL 29.14 mL 58.28 mL
2.5 mM 1.17 mL 5.83 mL 11.66 mL
5 mM 0.58 mL 2.91 mL 5.83 mL
25 mM 0.12 mL 0.58 mL 1.17 mL

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References

References are publications that support the biological activity of the product.

Wagner et al (2013) Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. Acta Neuropathol. 125 795 PMID: 23604588


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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease

Pathways for Anle138b

MAPK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.