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Oligomeric aggregation inhibitor. Inhibits formation of pathological prion protein (PrPSc) and α-synuclein aggregates in vitro. Prevents accumulation of PrPSc in brain and spleen, and prolongs survival of prion-infected mice. Exhibits neuroprotective effects in a Parkinson's disease mouse model and improves motor performance in an α-synucleinopathy model. Orally bioavailable and brain penetrant.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 343.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.83 mL||29.14 mL||58.28 mL|
|2.5 mM||1.17 mL||5.83 mL||11.66 mL|
|5 mM||0.58 mL||2.91 mL||5.83 mL|
|25 mM||0.12 mL||0.58 mL||1.17 mL|
References are publications that support the biological activity of the product.
Wagner et al (2013) Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. Acta Neuropathol. 125 795 PMID: 23604588
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Keywords: Anle138b, Anle138b supplier, oligomeric, aggregation, inhibitors, inhibits, prions, PrPSc, alpha, alfa, α, synuclein, synucleinopathies, brain, penetrant, Parkinson's, disease, Prion, Protein, 6861, Tocris Bioscience
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