VH 032 amide-alkylC8-amine

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Description: VHL ligand with alkyl linker and terminal amine for onward chemistry
Alternative Names: (S,R,S)-AHPC-C8-NH2
Chemical Name: (2S,4R)-1-((S)-2-(9-Aminononanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity: ≥95% (HPLC)
Literature (1)

Biological Activity for VH 032 amide-alkylC8-amine

VH 032 amide-alkylC8-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development; incorporates an E3 ligase ligand plus an alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

This product has been renamed. The previous name for this product was VH 032 - linker 11

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines for VH 032 amide-alkylC8-amine

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for VH 032 amide-alkylC8-amine

M. Wt 658.72
Formula C31H47N5O4S.2HCl
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2341796-80-1
Smiles CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCCCCCN)=O)=O)O)=O)SC=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for VH 032 amide-alkylC8-amine

Certificate of Analysis / Product Datasheet
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References for VH 032 amide-alkylC8-amine

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Keywords: VH 032 amide-alkylC8-amine, VH 032 amide-alkylC8-amine supplier, VH032, -, linker, 11, Proteolysis, Targeting, Chimera, PROTACs, VHL, E3, ubiquitin, ligase, alkyl, inker, conjugate, PROTAC, von-Hippel-Lindau, protein, ligand, degrader, building, blocks, (S,R,S)-AHPC-C8-NH2, Ligands, Plus, Linkers, 6890, Tocris Bioscience

Citations for VH 032 amide-alkylC8-amine

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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia