Sorafenib

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Description: Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and cKIT
Chemical Name: 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity for Sorafenib

Sorafenib is a potent Raf inhibitor (IC50 values are 6, 22 and 38 nM for Raf-1, wild-type BRAF and V599E BRAF mutant, respectively). Also inhibits mVEGFR-2, mVEGFR-3, mPDGFR-β, Flt-3, cKIT and VEGFR-2 (IC50 values are 15, 20, 57, 58, 68 and 90 nM, respectively). Inhibits MAPK pathway in colon, pancreatic and breast cancer cells expressing mutant KRAS and mutant or wt BRAF in vitro. Exhibits antitumor activity in colon, breast and non small-cell lung cancer xenograft models. Also induces ferroptosis in hepatocellular carcinoma cells in vitro.

Compound Libraries for Sorafenib

Sorafenib is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Sorafenib

M. Wt 464.82
Formula C21H16ClF3N4O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 284461-73-0
PubChem ID 216239
InChI Key MLDQJTXFUGDVEO-UHFFFAOYSA-N
Smiles CNC(C1=CC(OC2=CC=C(C=C2)NC(NC3=CC(C(F)(F)F)=C(C=C3)Cl)=O)=CC=N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Sorafenib

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.3 20

Preparing Stock Solutions for Sorafenib

The following data is based on the product molecular weight 464.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 10.76 mL 53.78 mL 107.57 mL
1 mM 2.15 mL 10.76 mL 21.51 mL
2 mM 1.08 mL 5.38 mL 10.76 mL
10 mM 0.22 mL 1.08 mL 2.15 mL

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References for Sorafenib

References are publications that support the biological activity of the product.

Wilhelm et al (2004) BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 64 7099 PMID: 15466206

Lachaier et al (2014) Sorafenib induces ferroptosis in human cancer cell lines originating from different solid tumors. Anticancer Res. 34 6417 PMID: 25368241


If you know of a relevant reference for Sorafenib, please let us know.

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Keywords: Sorafenib, Sorafenib supplier, potent, Raf, inhibitors, multikinase, inhibits, BRAF, KRAS, MAPK, signaling, pathway, anticancer, VEGFR, PDGFR, beta, Flt-3, cKIT, Kinase, FLT3, Ferroptosis, 6814, Tocris Bioscience

1 Citation for Sorafenib

Citations are publications that use Tocris products. Selected citations for Sorafenib include:

Grace et al (2022) Effect of CRISPR Knockout of AXIN1 or ARID1A on Proliferation and Migration of Porcine Hepatocellular Carcinoma. Front Oncol 12 904031 PMID: 35669430


Do you know of a great paper that uses Sorafenib from Tocris? Please let us know.

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