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Potent Raf inhibitor (IC50 values are 6, 22 and 38 nM for Raf-1, wild-type BRAF and V599E BRAF mutant, respectively). Also inhibits mVEGFR-2, mVEGFR-3, mPDGFR-β, Flt-3, cKIT and VEGFR-2 (IC50 values are 15, 20, 57, 58, 68 and 90 nM, respectively). Inhibits MAPK pathway in colon, pancreatic and breast cancer cells expressing mutant KRAS and mutant or wt BRAF in vitro. Exhibits antitumor activity in colon, breast and non small-cell lung cancer xenograft models. Also induces ferroptosis in hepatocellular carcinoma cells in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 464.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||10.76 mL||53.78 mL||107.57 mL|
|1 mM||2.15 mL||10.76 mL||21.51 mL|
|2 mM||1.08 mL||5.38 mL||10.76 mL|
|10 mM||0.22 mL||1.08 mL||2.15 mL|
References are publications that support the biological activity of the product.
Wilhelm et al (2004) BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 64 7099 PMID: 15466206
Lachaier et al (2014) Sorafenib induces ferroptosis in human cancer cell lines originating from different solid tumors. Anticancer Res. 34 6417 PMID: 25368241
If you know of a relevant reference for Sorafenib, please let us know.
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Keywords: Sorafenib, Sorafenib supplier, potent, Raf, inhibitors, multikinase, inhibits, BRAF, KRAS, MAPK, signaling, pathway, anticancer, VEGFR, PDGFR, beta, Flt-3, cKIT, Kinase, FLT3, Ferroptosis, 6814, Tocris Bioscience
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