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Description: ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor; inhibits leukemia stem cell self-renewal
Chemical Name: 3-β-D-Ribofuranosyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine
Purity: ≥98% (HPLC)

Biological Activity for 8-Azaadenosine

8-Azaadenosine is an ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor. Reduces A-to-I editing activity in a leukemia cell line, restores let-7 and inhibits leukemia stem cells self-renewal in vitro.

Compound Libraries for 8-Azaadenosine

8-Azaadenosine is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for 8-Azaadenosine

M. Wt 268.23
Formula C9H12N6O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 10299-44-2
PubChem ID 96410
Smiles NC1=NC=NC2=C1N=NN2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 8-Azaadenosine

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.82 100

Preparing Stock Solutions for 8-Azaadenosine

The following data is based on the product molecular weight 268.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.73 mL 18.64 mL 37.28 mL
5 mM 0.75 mL 3.73 mL 7.46 mL
10 mM 0.37 mL 1.86 mL 3.73 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

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Product Datasheets for 8-Azaadenosine

Certificate of Analysis / Product Datasheet
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References for 8-Azaadenosine

References are publications that support the biological activity of the product.

Zipeto et al (2016) ADAR1 activation drives leukemia stem cell self-renewal by impairing let-7 biogenesis. Cell Stem Cell 19 177 PMID: 27292188

Zhang and Slack et al (2016) ADARs edit microRNAs to promote leukemic stem cell activity. Cell Stem Cell 19 141 PMID: 27494666

If you know of a relevant reference for 8-Azaadenosine, please let us know.

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Keywords: 8-Azaadenosine, 8-Azaadenosine supplier, ADAR1, adenosine, deaminases, acting, on, double-stranded, RNA, dsRNA, leukemia, stem, cells, LSC, self-renewal, inhibitors, inhibits, Deaminases, Cancer, Stem, Cells, 6868, Tocris Bioscience

Citations for 8-Azaadenosine

Citations are publications that use Tocris products.

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