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Biological Activity for 8-Azaadenosine
8-Azaadenosine is an ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor. Reduces A-to-I editing activity in a leukemia cell line, restores let-7 and inhibits leukemia stem cells self-renewal in vitro.
Compound Libraries for 8-Azaadenosine
Technical Data for 8-Azaadenosine
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 8-Azaadenosine
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for 8-Azaadenosine
The following data is based on the product molecular weight 268.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.73 mL||18.64 mL||37.28 mL|
|5 mM||0.75 mL||3.73 mL||7.46 mL|
|10 mM||0.37 mL||1.86 mL||3.73 mL|
|50 mM||0.07 mL||0.37 mL||0.75 mL|
References for 8-Azaadenosine
References are publications that support the biological activity of the product.
Zipeto et al (2016) ADAR1 activation drives leukemia stem cell self-renewal by impairing let-7 biogenesis. Cell Stem Cell 19 177 PMID: 27292188
Zhang and Slack et al (2016) ADARs edit microRNAs to promote leukemic stem cell activity. Cell Stem Cell 19 141 PMID: 27494666
If you know of a relevant reference for 8-Azaadenosine, please let us know.
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Keywords: 8-Azaadenosine, 8-Azaadenosine supplier, ADAR1, adenosine, deaminases, acting, on, double-stranded, RNA, dsRNA, leukemia, stem, cells, LSC, self-renewal, inhibitors, inhibits, Deaminases, Cancer, Stem, Cells, 6868, Tocris Bioscience
Citations for 8-Azaadenosine
Citations are publications that use Tocris products.
Currently there are no citations for 8-Azaadenosine. Do you know of a great paper that uses 8-Azaadenosine from Tocris? Please let us know.
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Literature in this Area
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