Life Science Posters

A range of posters authored by leading experts

Authored by leading experts in the field, and summarizing key areas of research, the following range of life science posters provide a colorful and informative source of information. In addition, we have a series of cancer posters adapted from the Cancer Product Guide, Edition 3. We invite you to request* or download your copy today.

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Addiction Life Science Poster

Addiction

Mechanisms of Addiction

Prof David Nutt, Imperial College London

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Allosteric GPCR Pharmacology Life Science Poster

Allosteric GPCR Pharmacology

Arthur Christopoulos, David Thal, Denise Wootten and Patrick M. Sexton. Monash University

G protein-coupled receptors (GPCRs) are intrinsically allosteric proteins. This poster provides insights into allosteric mechanisms of GPCR biology, highlighting key facets of GPCR allostery and therapeutic applications of allosteric modulators.

Alzheimer's Disease Life Science Poster

Alzheimer's Disease

Alzheimer's Disease Neuropathology and Epidemiology

Dimitra Sokolova and Soyon Hong, University College London

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.

Angiogenesis in Cancer Life Science Poster

Angiogenesis in Cancer

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Autophagy Life Science Poster

Autophagy

Autophagy: Mechanisms and Function

Patricia Boya, CSIC
Patrice Codogno, University Paris-Descartes

Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.

Cancer Metabolism Life Science Poster

Cancer Metabolism

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.

Cell Cycle & DNA Damage Repair Life Science Poster

Cell Cycle & DNA Damage Repair

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Depression Life Science Poster

Depression

Antidepressants - Current and Future Targets

Phil Skolnick, National Institutes of Health
Piotr Popik, Jagiellonian University
Ramon Trullas, Consejo Superior de Investigaciones Científicas (CSIC)

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Epigenetics in Cancer Life Science Poster

Epigenetics in Cancer

This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.

GPCR Efficacy and Biased Agonism Life Science Poster

GPCR Efficacy and Biased Agonism

Patrick M. Sexton, Arthur Christopoulos and Denise Wootten, Monash University and Fudan University

GPCRs can interact with multiple distinct transducers or regulatory proteins and these can be preferentially engaged in an agonist-specific manner giving rise to biased agonism. This poster discusses cutting edge GPCR signaling pharmacology and highlights therapeutic applications of biased agonism.

Gut Hormones Life Science Poster

Gut Hormones

Gut Hormones and Metabolism

Rebeccca Scott and Stephen R. Bloom, Imperial College London

The gastrointestinal tract is the largest endocrine gland in the human body, secreting hormones that affect digestion, appetite and energy expenditure. Neuropeptide modulators and gut hormones that influence appetite are reviewed in this poster.

Huntington's Disease Life Science Poster

Huntington's Disease

Huntington's Disease: Pathophysiology and Clinical Prospects

Nina Stöberl and Nicholas Allen, University of Cardiff

Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.

Learning & Memory Life Science Poster

Learning & Memory

Neurotransmitters of Synaptic Plasticity, Learning and Memory in the Perirhinal Cortex

E. Clea Warburton and Zafar I. Bashir, University of Bristol

Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.

Multiple Sclerosis Life Science Poster

Multiple Sclerosis

Multiple Sclerosis: from Neurobiology to Therapy

Alastair Wilkins and Richard Ibitoye

Multiple sclerosis (MS) is an autoimmune disease that is characterized by focal demyelination and axon degeneration in the central nervous system. This poster summarizes the neurobiology and current therapies of MS.

Parkinson's Disease Life Science Poster

Parkinson's Disease

Parkinson's Disease: Neurobiology and Therapeutic Strategies

Anthony H.V. Schapira, University College London

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Programmed Cell Death Life Science Poster

Programmed Cell Death

Apoptosis, Necroptosis and Cell Survival

Bram van Raam, Universiteit Gent
Guy Salvesen, Sanford-Burnham Medical Research Institute

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Rheumatoid Arthritis Life Science Poster

Rheumatoid Arthritis

Epigenetic Drug Targets

Adam P. Cribbs, Marc Feldmann and Udo Oppermann, University of Oxford

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.

Stem Cell Workflow Life Science Poster

Stem Cell Workflow

Using Small Molecules

Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.

Stem Cells Life Science Poster

Stem Cells

Stem Cells and Differentiation

Rebecca Quelch and Stefan Przyborski

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.