NNC 0640

Pricing Availability   Qty
Description: Negative allosteric modulator of glucagon and GLP-1 receptors
Chemical Name: 4-[[(4-Cyclohexylphenyl)[[[3-(methylsulfonyl)phenyl]amino]carbonyl]amino]methyl]-N-2H-tetrazol-5-ylbenzamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for NNC 0640

NNC 0640 is a negative allosteric modulator of glucagon receptors (pKi = 7.4). Binds to external surface of the transmembrane domain. Also negative allosteric modulator of glucagon-like peptide 1 (GLP-1) receptor. Inhibits GLP-1-mediated cAMP accumulation in vitro.

Technical Data for NNC 0640

M. Wt 573.67
Formula C29H31N7O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 307986-98-7
PubChem ID 23549991
Smiles CS(=O)(C1=CC=CC(NC(N(C2=CC=C(C3CCCCC3)C=C2)CC4=CC=C(C(NC5=NN=NN5)=O)C=C4)=O)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NNC 0640

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 57.37 100

Preparing Stock Solutions for NNC 0640

The following data is based on the product molecular weight 573.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.74 mL 8.72 mL 17.43 mL
5 mM 0.35 mL 1.74 mL 3.49 mL
10 mM 0.17 mL 0.87 mL 1.74 mL
50 mM 0.03 mL 0.17 mL 0.35 mL

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References for NNC 0640

References are publications that support the biological activity of the product.

Zhang et al (2017) Structure of the full-length glucagon class B g-protein-coupled receptor. Nature. 546 259 PMID: 28514451

Jazayeri et al (2016) Extra-helical binding site of a glucagon receptor antagonist. Nature. 533 274 PMID: 27111510

Song et al (2017) Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature. 546 213 PMID: 28514449

If you know of a relevant reference for NNC 0640, please let us know.

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Citations for NNC 0640

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.