You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
NNC 0640 New
Negative allosteric modulator of glucagon receptors (pKi = 7.4). Binds to external surface of the transmembrane domain. Also negative allosteric modulator of glucagon-like peptide 1 (GLP-1) receptor. Inhibits GLP-1-mediated cAMP accumulation in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 573.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.74 mL||8.72 mL||17.43 mL|
|5 mM||0.35 mL||1.74 mL||3.49 mL|
|10 mM||0.17 mL||0.87 mL||1.74 mL|
|50 mM||0.03 mL||0.17 mL||0.35 mL|
References are publications that support the biological activity of the product.
Zhang et al (2017) Structure of the full-length glucagon class B g-protein-coupled receptor. Nature. 546 259 PMID: 28514451
Jazayeri et al (2016) Extra-helical binding site of a glucagon receptor antagonist. Nature. 533 274 PMID: 27111510
Song et al (2017) Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature. 546 213 PMID: 28514449
If you know of a relevant reference for NNC 0640, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: NNC 0640, NNC 0640 supplier, NNC0640, glucagon, receptor, glucagon-like, peptide, 1, GLP-1, GLP-1R, negative, allosteric, modulators, modulates, NAMs, GCGR, Glucagon, Receptor, Glucagon-Like, Peptide, Receptors, 6807, Tocris Bioscience
Citations for NNC 0640
Citations are publications that use Tocris products.
Currently there are no citations for NNC 0640. Do you know of a great paper that uses NNC 0640 from Tocris? Please let us know.
Reviews for NNC 0640
There are currently no reviews for this product. Be the first to review NNC 0640 and earn rewards!
Have you used NNC 0640?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.