Pricing Availability   Qty
Description: RIPK2 modulator; pro-drug of cRIPGM; orally bioavailable and brain penetrant
Chemical Name: N-[1,4-Dihydro-1,4-dioxo-3-[(phenylmethyl)amino]-2-naphthalenyl]-N-[(4-fluorophenyl)methyl]acetamide
Purity: ≥98% (HPLC)

Biological Activity for RIPGBM

RIPGBM is a RIPK2 modulator, pro-drug of cRIPGM. cRIPGM binds RIPK2 (apparent Kd = 2.3 μM). Selectively induces apoptosis in glioblastoma multiforme cancer stem cell lines (EC50 is <500 nM). Five-fold selective for CSCs compared with control cell types. Reduces the formation of a prosurvival RIPK2/ TAK1 complex and increases the formation of a proapoptotic RIPK2/caspase 1 complex. Inhibits tumor formation and growth in vivo. Orally bioavailable and brain penetrant.

Technical Data for RIPGBM

M. Wt 428.46
Formula C26H21FN2O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 355406-76-7
Smiles CC(=O)N(CC1=CC=C(F)C=C1)C1=C(NCC2=CC=CC=C2)C(=O)C2=CC=CC=C2C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RIPGBM

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 4.28 10

Preparing Stock Solutions for RIPGBM

The following data is based on the product molecular weight 428.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.34 mL 116.7 mL 233.39 mL
0.5 mM 4.67 mL 23.34 mL 46.68 mL
1 mM 2.33 mL 11.67 mL 23.34 mL
5 mM 0.47 mL 2.33 mL 4.67 mL

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References for RIPGBM

References are publications that support the biological activity of the product.

Lucki et al (2019) A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer. Proc.Natl.Acad.Sci.USA. 116 6435 PMID: 30846550

If you know of a relevant reference for RIPGBM, please let us know.

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Keywords: RIPGBM, RIPGBM supplier, Pro-drug, cRIPGM, RIPK2, modulators, modulates, apoptosis, glioblastoma, multiforme, cancer, orally, bioavailable, and, brain, penetrant., RIP, Kinases, 6892, Tocris Bioscience

Citations for RIPGBM

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