RIPGBM

Pricing Availability   Qty
Cat.No. 6892 - RIPGBM | C26H21FN2O3 | CAS No. 355406-76-7
Description: RIPK2 modulator; pro-drug of cRIPGM; orally bioavailable and brain penetrant
Chemical Name: N-[1,4-Dihydro-1,4-dioxo-3-[(phenylmethyl)amino]-2-naphthalenyl]-N-[(4-fluorophenyl)methyl]acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

RIPK2 modulator, pro-drug of cRIPGM. cRIPGM binds RIPK2 (apparent Kd = 2.3 μM). Selectively induces apoptosis in glioblastoma multiforme cancer stem cell lines (EC50 is <500 nM). Five-fold selective for CSCs compared with control cell types. Reduces the formation of a prosurvival RIPK2/ TAK1 complex and increases the formation of a proapoptotic RIPK2/caspase 1 complex. Inhibits tumor formation and growth in vivo. Orally bioavailable and brain penetrant.

Technical Data

M. Wt 428.46
Formula C26H21FN2O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 355406-76-7
InChI Key COATXBHZYVUJQP-UHFFFAOYSA-N
Smiles CC(=O)N(CC1=CC=C(F)C=C1)C1=C(NCC2=CC=CC=C2)C(=O)C2=CC=CC=C2C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.28 10

Preparing Stock Solutions

The following data is based on the product molecular weight 428.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.34 mL 116.7 mL 233.39 mL
0.5 mM 4.67 mL 23.34 mL 46.68 mL
1 mM 2.33 mL 11.67 mL 23.34 mL
5 mM 0.47 mL 2.33 mL 4.67 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Lucki et al (2019) A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer. Proc.Natl.Acad.Sci.USA. 116 6435 PMID: 30846550


If you know of a relevant reference for RIPGBM, please let us know.

View Related Products by Product Action

View all Receptor Interacting Protein Kinase Modulators

Keywords: RIPGBM, RIPGBM supplier, Pro-drug, cRIPGM, RIPK2, modulators, modulates, apoptosis, glioblastoma, multiforme, cancer, orally, bioavailable, and, brain, penetrant., RIP, Kinases, 6892, Tocris Bioscience

Citations for RIPGBM

Citations are publications that use Tocris products.

Currently there are no citations for RIPGBM. Do you know of a great paper that uses RIPGBM from Tocris? Please let us know.

Reviews for RIPGBM

There are currently no reviews for this product. Be the first to review RIPGBM and earn rewards!

Have you used RIPGBM?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide [Spring/Summer 2019]

Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Chemogenetics
  • Epigenetics
  • Fluorescent Imaging
  • PROTACs
  • Signal Transduction
  • Stem Cells