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Biological Activity for Lapatinib
Lapatinib is a potent and selective dual ErbB2 (HER-2) and EGFR inhibitor (IC50 values are 9.8 and 10.2 nM, respectively). Selective for EGFR and ErbB-2 versus other proliferative kinases. Inhibits proliferation in multiple cancer cell lines (average IC50 values <0.16 μM). Exhibits 100-fold average selectivity for the tumor cells versus human foreskin fibroblasts. Inhibits EGFR/ErbB2 autophosphorylation and phosphorylation of the downstream modulator AKT.
Compound Libraries for Lapatinib
Technical Data for Lapatinib
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Lapatinib
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Lapatinib
The following data is based on the product molecular weight 581.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.72 mL||8.6 mL||17.21 mL|
|5 mM||0.34 mL||1.72 mL||3.44 mL|
|10 mM||0.17 mL||0.86 mL||1.72 mL|
|50 mM||0.03 mL||0.17 mL||0.34 mL|
References for Lapatinib
References are publications that support the biological activity of the product.
Rusnak et al (2001) The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol.Cancer Ther. 1 85 PMID: 12467226
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Keywords: Lapatinib, Lapatinib supplier, Potent, selective, dual, ErbB2, (HER-2), and, EGFR, inhibitors, inhibits, 6811, Tocris Bioscience
1 Citation for Lapatinib
Citations are publications that use Tocris products. Selected citations for Lapatinib include:
Gregory et al (2021) A ligand-receptor interactome platform for discovery of pain mechanisms and therapeutic targets. Sci Signal 14 PMID: 33727337
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Reviews for Lapatinib
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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