Search for new products by date added, alphabetically, or by pharmacological action.
New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the New symbol.
If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.
| Cat No | Product Name / Activity | Date Added |
|---|---|---|
| 6534 | TH 5427 hydrochloride | Nov 2018 |
| Potent NUDT5 inhibitor | ||
| 6363 | Avagacestat | Nov 2018 |
| Highly potent γ-secretase inhibitor; orally bioavailable | ||
| 6160 | VE 821 | Nov 2018 |
| High affinity and selective ATP-competitive ATR inhibitor | ||
| 5991 | BAY 598 | Nov 2018 |
| Potent and selective SMYD2 inhibitor | ||
| TB1254-GMP | Y-27632 dihydrochloride | Nov 2018 |
| Y-27632 synthesized to cGMP guidelines | ||
| 6669 | Gly MCA | Nov 2018 |
| FXR antagonist; selectively active in intestines; orally bioavailable | ||
| 6660 | Crotonic Acid | Nov 2018 |
| Enhances reprogramming to pluripotency; facilitates telomere maintenance and increases telomere length | ||
| 6658 | Telaprevir | Nov 2018 |
| Hepatitis C virus (HCV) protease NS3/4A inhibitor | ||
| 6645 | DJ-V 159 | Nov 2018 |
| GPRC6A agonist | ||
| 6461 | PARPi-FL | Nov 2018 |
| Potent fluorescent PARP inhibitor; cell permeable | ||
| 6315 | DMNB-caged-Serine | Nov 2018 |
| Caged serine; excited by visible blue light | ||
| 6106 | T 3364366 | Nov 2018 |
| Potent and reversible FADS1 inhibitor; orally bioavailable | ||
| 5494 | R 547 | Nov 2018 |
| Potent and selective CDK inhibitor; orally bioavailable | ||
| 6700 | PA Nic | Oct 2018 |
| Caged nicotine; photoactivated by one-photon and two-photon excitation | ||
| 6675 | H 151 | Oct 2018 |
| STING antagonist | ||
| 6522 | TH 1217 | Oct 2018 |
| Potent dCTP pyrophosphatase 1 inhibitor | ||
| 6198 | GSK 6853 | Oct 2018 |
| Potent and selective BRPF1 inhibitor | ||
| 6581 | PKUMDL WQ 2201 | Oct 2018 |
| Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH) | ||
| 6546 | Furanone C-30 | Oct 2018 |
| Quorum sensing inhibitor; antibacterial | ||
| 6662 | 4-Octyl itaconate | Oct 2018 |
| Nrf2 activator; cell permeable | ||
| 6657 | PA 8 | Oct 2018 |
| PAC1 receptor antagonist | ||
| 6443 | IU1-47 | Oct 2018 |
| Potent USP14 inhibitor | ||
| 6501 | Janelia Fluor® 549, Azide | Oct 2018 |
| Cell permeable yellow fluorescent dye; supplied as an azide for 'click' chemistry | ||
| 5948 | DMNPE-4 AM-caged-calcium | Oct 2018 |
| Caged calcium; cell permeable | ||
| 6568 | Dooku 1 | Oct 2018 |
| Reversibly blocks Yoda1 activity; does not affect constitutive Piezo1 activity | ||
| 6319 | CBM 301940 | Oct 2018 |
| Potent malonyl-CoA decarboxylase inhibitor; orally bioavailable | ||
| 6444 | MitoMark Green I | Oct 2018 |
| Green fluorescent mitochondrial stain | ||
| 6353 | UoS 12258 | Oct 2018 |
| Positive allosteric modulator of AMPA receptors | ||
| 6445 | MitoMark Red I | Oct 2018 |
| Red fluorescent mitochondrial stain | ||
| 6256 | OG 488 BAPTA-1 AM | Oct 2018 |
| Cell-permeable, fluorescent Ca2+ indicator | ||
| 6089 | Nexinhib20 | Oct 2018 |
| Rab27 inhibitor; inhibits neutrophil exocytosis; active in vivo | ||
| 5550 | E 2012 | Oct 2018 |
| γ-secretase modulator; Notch-sparing | ||
| 6594 | GSHtracer | Oct 2018 |
| Radiometric glutathione (GSH) probe | ||
| 6321 | 10-Cl-BBQ | Oct 2018 |
| Potent aryl hydrocarbon receptor (AhR) agonist; orally bioavailable | ||
| 6677 | CMA | Oct 2018 |
| Murine-selective STING agonist | ||
| 6663 | Silodosin | Oct 2018 |
| Selective α1A antagonist | ||
| 6588 | (+)-JQ1 carboxylic acid | Oct 2018 |
| Carboxylic acid-functionalized BET bromodomain inhibitor | ||
| 6364 | Squarunkin A hydrochloride | Oct 2018 |
| UNC119 chaperone-cargo interaction inhibitor; disrupts Src activation | ||
| 6477 | SAHM1 | Oct 2018 |
| Notch pathway inhibitor; prevents Notch complex assembly | ||
| 6615 | KCC 07 | Sep 2018 |
| MBD2 (Methyl-CpG-binding domain protein 2) inhibitor | ||
| 6584 | L-Azidohomoalanine hydrochloride | Sep 2018 |
| Unnatural amino acid for bio-orthogonal labeling of newly synthesized proteins | ||
| 6526 | Dynarrestin | Sep 2018 |
| Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein | ||
| 6642 | QWF | Sep 2018 |
| MRGPRX2 antagonist; also NK1 receptor antagonist | ||
| 6585 | L-Azidonorleucine hydrochloride | Sep 2018 |
| Unnatural amino acid for bio-orthogonal or fluorescent labeling of newly synthesized proteins | ||
| 6666 | T3 | Sep 2018 |
| Thyroid hormone; also promotes differentiation of oligodendroglial precursor cells | ||
| 6647 | HADA | Sep 2018 |
| Blue fluorescent D-amino acid for labeling peptidoglycans in live bacteria | ||
| 6646 | CDDO-Me | Sep 2018 |
| Nrf2 pathway activator; also NF-κB pathway inhibitor; inhibits IKKβ | ||
| 6537 | UNC 2881 | Sep 2018 |
| Potent Mer kinase inhibitor | ||
| 6236 | O8 OGG1 Inhibitor | Sep 2018 |
| Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor | ||
| 6602 | 1M7 | Sep 2018 |
| Reagent for RNA SHAPE-MaP chemistry | ||
| 6589 | (+)-JQ1 PA | Sep 2018 |
| 'Click' target ligand for PROTACs; functionalized BET bromodomain inhibitor | ||
| 6531 | NLS-StAx-h | Sep 2018 |
| Wnt signaling inhibitor; inhibits β-catenin-transcription factor interactions | ||
| 6516 | EPZ 015666 | Sep 2018 |
| Potent and selective PRMT5 inhibitor | ||
| 6576 | ABT 594 hydrochloride | Sep 2018 |
| Selective α4β2 nAChR agonist | ||
| 6655 | Amifostine | Sep 2018 |
| Cytoprotectant | ||
| 6475 | SU 6656 | Sep 2018 |
| Potent ATP-competitive Src family kinase inhibitor; also AMPK inhibitor; cell permeable | ||
| 6126 | KRH 3955 hydrochloride | Sep 2018 |
| Highly potent CXCR4 antagonist; inhibits HIV-1 replication | ||
| 5957 | C3 | Sep 2018 |
| Selective microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor | ||
| 6067 | M 30 dihydrochloride | Sep 2018 |
| Potent and non-selective MAO inhibitor; also an iron chelator and antioxidant | ||
| 6257 | OG 488, SE | Sep 2018 |
| Green fluorescent dye; supplied as NHS ester | ||
| 6648 | NADA-green | Sep 2018 |
| Fluorescent D-amino acid for labeling peptidoglycans in live bacteria | ||
| 6508 | GSK 1702934A | Sep 2018 |
| Potent and selective TRPC3/6 activator | ||
| 6492 | GSK'872 | Sep 2018 |
| Potent and selective receptor activating protein kinase 3 (RIP3) inhibitor | ||
| 6482 | XMU MP 1 | Sep 2018 |
| Potent and selective MST1/2 inhibitor; orally bioavailable | ||
| 6255 | Fluo-4 AM | Sep 2018 |
| Cell-permeable, fluorescent Ca2+ indicator | ||
| 6254 | Flutax 2 | Sep 2018 |
| Green fluorescent taxol derivative | ||
| 6614 | Jedi2 | Sep 2018 |
| Piezo1 channel activator | ||
| 6349 | Pelitinib | Sep 2018 |
| Potent and irreversible EGFR inhibitor; orally bioavailable | ||
| 4970 | BMS 688521 | Sep 2018 |
| Potent inhibitor of the LFA-1/ICAM interaction | ||
| 6556 | Anti-human EGFR aptamer, Janelia Fluor® 646 conjugate | Aug 2018 |
| High affinity anti-human EGFR aptamer conjugated to Janelia Fluor® 646 | ||
| 6557 | Anti-human ErbB2 aptamer, Janelia Fluor® 646 conjugate | Aug 2018 |
| High affinity anti-human ErbB2 aptamer conjugated to Janelia Fluor® 646 | ||
| 6547 | Ambuic Acid | Aug 2018 |
| Quorum sensing inhibitor; antibacterial | ||
| 6528 | SGC AAK1 1 | Aug 2018 |
| AAK1 and BMP2K inhibitor; activates Wnt signaling | ||
| 6367 | Z 944 | Aug 2018 |
| Ca2+ channel blocker (T-type) | ||
| 6637 | Pomalidomide - linker 1 | Aug 2018 |
| Pomalidomide-PEG2-ethylamine | ||
| 6532 | THAL SNS 032 | Aug 2018 |
| Potent and selective CDK9 degrading PROTAC | ||
| 6638 | GSK 626616 | Aug 2018 |
| Potent and selective DYRK inhibitor; orally bioavailable. | ||
| 6632 | ERGi-USU | Aug 2018 |
| Rio2 kinase (RIOK2) inhibitor; inhibits ERG protein | ||
| 6627 | Thalidomide - linker 4 | Aug 2018 |
| Thalidomide-alkylC6-amine | ||
| 6583 | UCLA GP130 2 | Aug 2018 |
| gp130 agonist; brain penetrant and neuroprotectant | ||
| 6559 | LY 450139 | Aug 2018 |
| γ-secretase pseudo-inhibitor | ||
| 6400 | Alsterpaullone | Aug 2018 |
| Potent CDK1 and 2 inhibitor; also inhibits GSK-3β and Lck | ||
| 6323 | FX 1 | Aug 2018 |
| BCL6 inhibitor; 10-fold more potent than endogenous BCL6 corepressors | ||
| 6269 | JT010 | Aug 2018 |
| Potent and selective TRPA1 channel activator | ||
| 6641 | Roflumilast | Aug 2018 |
| Potent and selective PDE4 inhibitor | ||
| 6229 | LP 922761 | Aug 2018 |
| Potent AAK1 inhibitor; peripherally restricted | ||
| 4690 | Fmk | Aug 2018 |
| Irreversible ribosomal S6 kinase inhibitor 1/2 inhibitor | ||
| 6524 | TL 12-186 | Jul 2018 |
| Multikinase degrading PROTAC | ||
| 6628 | TC E3 5032 | Jul 2018 |
| Precursor to Pomalidomide-based PROTACs | ||
| 6330 | AZ 5704 | Jul 2018 |
| Potent and selective ATM kinase inhibitor; orally bioavailable | ||
| 6428 | Carboprost tromethamine | Jul 2018 |
| Synthetic Prostaglandin F2α (Cat. No. 4214) analog | ||
| 6425 | PSEM 308 hydrochloride | Jul 2018 |
| PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist | ||
| 6454 | LY 2603618 | Jul 2018 |
| Potent and selective Chk1 inhibitor | ||
| 6555 | TokeOni | Jul 2018 |
| NIR-emission luciferin analog; orally bioavailable and brain penetrant | ||
| 6539 | Obatoclax mesylate | Jul 2018 |
| Inhibitor of Bcl-2 family members; antiapoptotic | ||
| 6525 | TL 13-27 | Jul 2018 |
| Negative control for TL 12-186 | ||
| 6426 | PSEM 89S | Jul 2018 |
| PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist | ||
| 6422 | DREADD agonist 21 dihydrochloride | Jul 2018 |
| Potent muscarinic DREADD agonist; water soluble version of DREADD agonist 21 (Cat. No. 5548) | ||
| TB1614-GMP | SB 431542 | Jul 2018 |
| SB 431542 synthesized to cGMP guidelines | ||
| 6545 | OB-1 | Jul 2018 |
| Stomatin-like protein-3 (STOML3) oligomerization inhibitor | ||
| TB2634-GMP | DAPT | Jul 2018 |
| DAPT synthesized to cGMP guidelines | ||
| 6483 | Isoginkgetin | Jul 2018 |
| Pre-mRNA splicing inhibitor; cell permeable | ||
| 4007 | Laulimalide | Jul 2018 |
| Microtubule stabilzing agent | ||
| 6153 | JQEZ5 | Jul 2018 |
| Potent and selective SAM-competitive EZH2 inhibitor | ||
| 5910 | TL4-12 | Jul 2018 |
| Potent MAP4K2 (GCK) inhibitor | ||
| 6480 | GSK 583 | Jul 2018 |
| Potent RIP2 kinase inhibitor; orally bioavailable and cell permeable | ||
| 6542 | Ivabradine hydrochloride | Jul 2018 |
| HCN channel blocker; inhibits If pacemaker current | ||
| 6538 | PF 04449913 maleate | Jul 2018 |
| Potent Smo antagonist | ||
| 6476 | Compound E | Jul 2018 |
| γ-secretase inhibitor; induces neuronal differentiation | ||
| 6517 | Liraglutide | Jul 2018 |
| Highly potent, long-acting GLP-1 receptor agonist | ||
| 6486 | Aprepitant | Jul 2018 |
| Potent long-acting hNK-1 antagonist | ||
| 6479 | CU CPT 9a | Jul 2018 |
| Potent TLR8 inhibitor | ||
| 6520 | Abiraterone acetate | Jul 2018 |
| Potent CYP17A1 inhibitor | ||
| 6506 | PF 06551600 malonate | Jul 2018 |
| Potent and selective JAK3 inhibitor | ||
| 6491 | YM 155 | Jul 2018 |
| Survivin suppressor | ||
| 6199 | BAY 876 | Jul 2018 |
| Potent and selective GLUT1 inhibitor | ||
| 6578 | GT 949 | Jul 2018 |
| Potent and selective positive allosteric modulator of EAAT2 | ||
| 6544 | CID 1375606 | Jul 2018 |
| GPR27 agonist | ||
| 6324 | Autophinib | Jul 2018 |
| Potent VPS34 inhibitor | ||
| 6281 | SLM 6031434 hydrochloride | Jul 2018 |
| Selective sphingosine kinase 2 (Sphk2) inhibitor | ||
| 6436 | CY 09 | Jul 2018 |
| NLRP3 inhibitor; active in vivo | ||
| 6273 | CRT 0105950 | Jul 2018 |
| Potent LIMK1/2 inhibitor | ||
| 5767 | SR 3029 | Jul 2018 |
| Potent and selective CK1δ and CK1ε inhibitor | ||
| 6564 | SGC GAK 1 | Jul 2018 |
| High affinity cyclin G associated kinase (GAK) inhibitor | ||
| 6320 | ESI 05 | Jul 2018 |
| Epac2 inhibitor | ||
| 6558 | CP 43 | Jul 2018 |
| Potent TAOK inhibitor | ||
| 6239 | SAK 3 | Jul 2018 |
| Potent CaV3.1/3.3 activator; orally bioavailable | ||
| 6179 | UK 59811 hydrochloride | Jul 2018 |
| CaVAb blocker | ||
| 6040 | BRD 9757 | Jul 2018 |
| Potent and selective HDAC6 inhibitor | ||
| 6505 | Avasimibe | Jun 2018 |
| ACAT inhibitor | ||
| 6554 | (+)-Abscisic Acid | Jun 2018 |
| Endogenous LANCL2 agonist | ||
| 6448 | ML 351 | Jun 2018 |
| Selective 12/15 LOX inhibitor; active in vivo | ||
| 6144 | CX08005 | Jun 2018 |
| Competitive PTP1B inhibitor | ||
| 6037 | LM22B 10 | Jun 2018 |
| TrkB and TrkC agonist; brain penetrant | ||
| 6079 | TC KHNS 11 | Jun 2018 |
| Potent and selective PI 3-kinase δ inhibitor; orally bioavailable | ||
| 5828 | Ambrisentan | Jun 2018 |
| Selective ETA antagonist | ||
| 6406 | Hydroxystilbamidine bis(methanesulfonate) | Jun 2018 |
| Fluorescent cationic dye; neuronal tracer | ||
| 6572 | Biotin-LC-NAD+ | Jun 2018 |
| Biotinylated analog of β-NAD+; commonly used reagent in LSD1 and PARP1 assays | ||
| 6549 | cAC 253 | Jun 2018 |
| Amylin (AMY3) receptor antagonist; brain penetrant | ||
| 6296 | Janelia Fluor® 525, SE | Jun 2018 |
| Cell permeable yellow fluorescent dye; supplied as NHS ester | ||
| 6571 | Biotin-11-dUTP | Jun 2018 |
| Biotin-labeled dUTP | ||
| 6551 | PAMP-12 (human, porcine) | Jun 2018 |
| Potent MRGPRX2 agonist | ||
| 6552 | PAMP-20 (human) | Jun 2018 |
| MRGPRX2 agonist | ||
| 6113 | Liproxstatin-1 hydrochloride | Jun 2018 |
| Potent ferroptosis inhibitor | ||
| 6548 | N-(3-Oxododecanoyl)-L-homoserine lactone | May 2018 |
| Bacterial quorum sensing autoinducer; immunomodulator | ||
| 6244 | OG-L002 | May 2018 |
| Potent LSD1 inhibitor | ||
| 6550 | AC 253 | May 2018 |
| Amylin (AMY3) receptor antagonist | ||
| 6017 | THPN | May 2018 |
| Nur77 agonist; induces autophagy in melanoma cell lines | ||
| 6484 | Terbinafine hydrochloride | May 2018 |
| Selective TASK3 activator; also inhibits fungal squalene epoxidase |