Search for new products by date added, alphabetically, or by pharmacological action.
New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the New symbol.
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| Cat. No. | Product Name / Activity | Date Added |
|---|---|---|
| 6978 | AZD 5363 | Aug 2019 |
| Potent pan-AKT inhibitor | ||
| 6994 | HODHBt | Aug 2019 |
| STAT5-SUMO protein-protein interaction inhibitor | ||
| 6623 | TFAX 546, SE | Aug 2019 |
| Yellow fluorescent dye; amine reactive | ||
| 6619 | TFAX 488, SE | Aug 2019 |
| Green fluorescent dye; amine reactive | ||
| 5861 | ARN 726 | Aug 2019 |
| Potent N-acylethanolamine acid amidase (NAAA) inhibitor; NAAA activity-based protein profiling (ABPP) probe | ||
| 6109 | Methylnaltrexone bromide | Aug 2019 |
| μ antagonist; peripherally restricted | ||
| 6927 | Glucagon (Human, Porcine) | Aug 2019 |
| Endogenous glucagon receptor agonist | ||
| 6930 | Amphotericin B | Aug 2019 |
| Forms monovalent ion channels in lipid bilyers; antifungal | ||
| 6859 | FITM | Aug 2019 |
| Potent and selective negative allosteric modulator of mGlu1 receptors | ||
| 6921 | BSJ-03-123 | Aug 2019 |
| Selective Cdk6 degrader | ||
| 6922 | BSJ-Bump | Aug 2019 |
| Negative control for BSJ-03-123 | ||
| 6054 | R162 | Aug 2019 |
| Glutamate dehydrogenase (GDH1) inhibitor | ||
| 6823 | CycLuc 1 | Jul 2019 |
| Synthetic luciferase substrate; brain penetrant; displays NIR emission | ||
| 6902 | OLT 1177 | Jul 2019 |
| NLRP3 inflammasome inhibitor; disrupts inflammasome formation | ||
| 6954 | L-Buthionine sulfoximine | Jul 2019 |
| Irreversible γ-glutamylcysteine synthetase (γ-GCS) inhibitor; induces ferroptosis | ||
| 6751 | (R)-(-)-Ketamine hydrochloride | Jul 2019 |
| NMDA antagonist; antidepressant; may not display psychotomimetic or addictive side effects of (S)-ketamine | ||
| 6776 | G5 | Jul 2019 |
| Ubiquitin isopeptidase inhibitor; induces apoptosis | ||
| 6986 | EG 00229 trifluoroacetate | Jul 2019 |
| Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1 | ||
| 6924 | Oridonin | Jul 2019 |
| High affinity NLRP3 inflammasome inhibitor | ||
| 6933 | CM 10 | Jul 2019 |
| ALDH1A inhibitor; depletes CD133+ cancer stem cells | ||
| 6904 | Idasanutlin | Jul 2019 |
| Potent MDM2 inhibitor; inhibits MDM2-p53 interaction | ||
| 6886 | ML 67-33 | Jul 2019 |
| K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) channel activator | ||
| 6757 | t-TUCB | Jul 2019 |
| Potent soluble epoxide hydrolase (sEH) Inhibitor; anti-inflammatory and antinociceptive. | ||
| 6920 | SAH-SOS1A | Jul 2019 |
| KRas/SOS1 interaction inhibitor | ||
| 6701 | 1A-116 | Jul 2019 |
| Rac1 inhibitor; blocks Rac1-P-Rex1 interaction | ||
| 6703 | BGP 15 | Jul 2019 |
| PARP inhibitor; cytoprotectant | ||
| 6969 | cis VH 032, amine dihydrochloride | Jul 2019 |
| Negative control for VH 032, amine (Cat. No. 6462) | ||
| 6500 | Janelia Fluor® 549, Maleimide | Jul 2019 |
| Cell permeable yellow fluorescent dye; supplied with a maleimide reactive group | ||
| 6910 | VH 032 phenol - linker 2 | Jul 2019 |
| VH 032 phenol-alkylC6-amine | ||
| 6909 | VH 032 phenol - linker 1 | Jul 2019 |
| VH 032 phenol-alkylC4-amine | ||
| 6228 | H10 | Jul 2019 |
| PARP14 inhibitor; cell-permeable | ||
| 6884 | TC SL C5 | Jul 2019 |
| Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor | ||
| 6903 | DPTIP | Jul 2019 |
| Potent and selective N-SMase2 inhibitor; brain penetrant | ||
| 6790 | GSK 126 | Jul 2019 |
| Very high affinity and selective EZH2 inhibitor | ||
| 6801 | Tocriscreen Epigenetics Library | Jul 2019 |
| A library of 101 epigenetic compounds (250 μL, 10 mM DMSO solutions) | ||
| 6877 | VU 0134992 | Jul 2019 |
| Kir4.1 blocker | ||
| 6960 | ABT 199 | Jul 2019 |
| Selective, high affinity Bcl-2 inhibitor; orally bioavailable | ||
| 6908 | TR 14035 | Jul 2019 |
| Potent integrin α4β7 and α4β1 antagonist; orally bioavailable | ||
| 6874 | AMG 333 | Jul 2019 |
| Potent and selective TRPM8 antagonist; active in vivo | ||
| 6957 | Reparixin L-lysine salt | Jun 2019 |
| Potent CXCR1 and CXCR2 allosteric antagonist | ||
| 6521 | I-BET 762 | Jun 2019 |
| Potent and high affinity BRD inhibitor; anti-inflammatory; orally bioavailable. | ||
| 6934 | 673 A | Jun 2019 |
| ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC) | ||
| 6956 | Galunisertib | Jun 2019 |
| ALK4 and ALK5 (TGFβRI) inhibitor | ||
| 6966 | Thalidomide - linker 13 | Jun 2019 |
| Thalidomide-PEG1-ethylamine | ||
| 6967 | Thalidomide - linker 14 | Jun 2019 |
| Thalidomide-PEG2-ethylamine | ||
| 6968 | Thalidomide - linker 15 | Jun 2019 |
| Thalidomide-alkylC6-amine | ||
| 6561 | BAY 6035 | Jun 2019 |
| Potent and selective SMYD3 inhibitor | ||
| 6887 | ML 335 | Jun 2019 |
| Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator | ||
| 6948 | CRBN-6-5-5-VHL | Jun 2019 |
| Potent and selective cereblon degrader; cell-permeable | ||
| 6905 | Ceritinib | Jun 2019 |
| Highly potent ALK inhibitor; also potently inhibits IR, IGF1R, STK22D and FLT3 | ||
| 6963 | Pomalidomide - linker 8 | Jun 2019 |
| Pomalidomide-PEG4-ethylamine | ||
| 6489 | Ocean Blue, SE | Jun 2019 |
| Blue fluorescent dye; supplied as NHS ester | ||
| 6917 | Thalidomide - linker 9 | Jun 2019 |
| Thalidomide-alkylC4-amine | ||
| 6716 | Pomalidomide - linker 4 | Jun 2019 |
| Pomalidomide-alkylC5-amine | ||
| 6854 | LY 3009120 | Jun 2019 |
| Potent pan-Raf kinase inhibitor | ||
| 6713 | ZXH 3-26 | Jun 2019 |
| Potent and selective BRD4 degrader | ||
| 6885 | PU 23 | May 2019 |
| Multidrug resistance protein (MRP) 4 inhibitor | ||
| 6495 | AM 12 | May 2019 |
| TRPC5 inhibitor | ||
| 6493 | A 317491 sodium salt | May 2019 |
| Selective, high affinity P2X3 and P2X2/3 receptor antagonist; antinociceptive | ||
| 6926 | Fenoprofen calcium | May 2019 |
| Positive allosteric modulator of MC3 receptors; exhibits biased signaling | ||
| 6837 | GSK 923295A | May 2019 |
| Potent and selective centromere associated protein E (CENP-E) allosteric inhibitor | ||
| 6891 | PND 1186 | May 2019 |
| Potent FAK inhibitor; orally bioavailable | ||
| 6872 | BQCA | May 2019 |
| Positive allosteric modulator of M1 receptors | ||
| 6778 | S 38093 | May 2019 |
| Selective H3 antagonist and inverse agonist; antinociceptive | ||
| 6665 | BI 9321 | May 2019 |
| Nuclear receptor-binding SET domain (NSD) 3 antagonist; selectively binds PWWP1 domain | ||
| 6433 | GSK 1016790A | May 2019 |
| Potent TRPV4 agonist; active in vivo | ||
| 6898 | Mitochondrial fusion promoter M1 | May 2019 |
| Mitochondrial fusion promoter | ||
| 6835 | ABT 737 | May 2019 |
| Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines | ||
| 6861 | Anle138b | May 2019 |
| Oligomeric aggregation inhibitor; inhibits prion protein and α-synuclein aggregate formation | ||
| 6817 | BAY 8002 | May 2019 |
| Potent dual MCT1/2 inhibitor; orally bioavailable | ||
| 6782 | Indisulam | May 2019 |
| Molecular glue; pre-mRNA splicing modulator | ||
| 6313 | A 33 | May 2019 |
| Potent and selective PDE4B inhibitor | ||
| 6949 | Thalidomide - linker 10 | May 2019 |
| Thalidomide-alkylC2-amine | ||
| 6882 | DiFMUP | May 2019 |
| Fluorescent phosphatase substrate | ||
| 6881 | SB 4 | May 2019 |
| Potent BMP4 agonist | ||
| 6690 | Ceralifimod | May 2019 |
| Highly potent and selective S1P1 and S1P5 agonist | ||
| 6951 | Thalidomide - linker 12 | May 2019 |
| Thalidomide-PEG5-ethylamine | ||
| 6935 | GSK J5 HCl | May 2019 |
| Inactive isomer of GSK J4 (Cat. No. 4594); cell permeable | ||
| 6815 | Selumetinib | May 2019 |
| Potent and selective MEK inhibitor; orally bioavailable | ||
| 6792 | Omipalisib | May 2019 |
| Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK | ||
| 6717 | FFN 270 | May 2019 |
| Fluorescent substrate for NET and VMAT2 | ||
| 5026 | KYT 0353 | May 2019 |
| Potent and selective inhibitor of L-type amino acid transporter 1 (LAT1); active in vivo | ||
| 6845 | RCM 1 | May 2019 |
| FOXM1 inhibitor | ||
| 6868 | 8-Azaadenosine | May 2019 |
| ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor; inhibits leukemia stem cell self-renewal | ||
| 6840 | AD 01 | May 2019 |
| FKBPL (FK506-binding protein like)-based peptide; inhibits breast cancer stem cell self-renewal; also antiangiogenic | ||
| 6832 | Ec2la | May 2019 |
| Positive allosteric modulator of CB2 receptors; active in vivo | ||
| 6829 | (R)-Shikonin | May 2019 |
| PTEN inhibitor; induces necroptosis; anti-inflammatory | ||
| 6771 | PHPS1 sodium salt | May 2019 |
| Shp2 (PTPN11) inhibitor | ||
| 6708 | SAH-EZH2 | May 2019 |
| EZH2/EDD interaction inhibitor; suppresses PCR2 complex function | ||
| 6362 | GSK 143 | May 2019 |
| Syk inhibitor | ||
| 6679 | VH 032 - linker 4 | Apr 2019 |
| VH 032-PEG3-CH2CH2COOH | ||
| 6355 | VU 0650991 | Apr 2019 |
| Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant | ||
| 6907 | VH 032 - linker 12 | Apr 2019 |
| VH 032-PEG2-amine | ||
| 6867 | Rhein | Apr 2019 |
| FTO (mRNA N6-methyladenine demethylase) inhibitor; also inhibits ALKBH2 and ALKBH3 | ||
| 6749 | TH 5487 | Apr 2019 |
| Selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor | ||
| 6763 | AVE 1625 | Apr 2019 |
| Potent and selective CB1 receptor antagonist | ||
| 6434 | DFHO | Apr 2019 |
| Mimic of RFP fluorophore for imaging RNA in living cells | ||
| 6378 | JMS 17-2 hydrochloride | Apr 2019 |
| CX3CR1 antagonist | ||
| 6852 | VH 032 - linker 7 | Apr 2019 |
| VH 032-alkylC2-amine | ||
| 6762 | Urolithin A | Apr 2019 |
| PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro | ||
| 6634 | Surfen | Apr 2019 |
| Heparin sulfate antagonist | ||
| 6510 | LNT 1 | Apr 2019 |
| Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response | ||
| 6575 | StRIP16 | Apr 2019 |
| Rab8a GTPase-binding stapled peptide | ||
| 6864 | Ticagrelor | Apr 2019 |
| High affinity and reversible P2Y12 antagonist; displays inverse agonism in vitro; also inhibits ENT1 | ||
| 6814 | Sorafenib | Apr 2019 |
| Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and cKIT | ||
| 6740 | Siramesine hydrochloride | Apr 2019 |
| High affinity σ agonist (σ2 > σ1) | ||
| 6451 | Pexacerfont | Apr 2019 |
| Potent and selective CRF1 antagonist; anxiolytic | ||
| 6856 | α-Mangostin | Apr 2019 |
| Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines | ||
| 6785 | E 7820 | Apr 2019 |
| α2 integrin inhibitor; anti-angiogenic | ||
| 6853 | VH 032 - linker 8 | Apr 2019 |
| VH 032-alkylC6-amine | ||
| 6748 | PRX 07034 | Apr 2019 |
| Potent and selective 5-HT6 antagonist | ||
| 6502 | Janelia Fluor® 549, Tetrazine | Apr 2019 |
| Cell permeable yellow fluorescent dye; supplied as a tetrazine for 'click' chemistry | ||
| 6811 | Lapatinib | Apr 2019 |
| Potent and selective dual ErbB2 (HER-2) and EGFR inhibitor | ||
| 6745 | TL 13-112 | Apr 2019 |
| Selective ALK Degrader | ||
| 6806 | AZ 3451 | Apr 2019 |
| Potent negative allosteric modulator of PAR2 receptors | ||
| 6746 | TL 13-110 | Apr 2019 |
| Negative control for TL 13-112 | ||
| 6813 | Ibrutinib | Apr 2019 |
| Potent and selective BTK inhibitor | ||
| 6747 | TL 13-22 | Apr 2019 |
| Negative control for TL 13-12 | ||
| 6744 | TL 13-12 | Apr 2019 |
| Selective ALK degrader | ||
| 6246 | BF 738735 | Apr 2019 |
| Potent and selective PI 4-kinase IIIβ inhibitor; broad spectrum enterovirus replication inhibitor | ||
| 5862 | ARN 14686 | Apr 2019 |
| Potent N-acylethanolamine acid amidase inhibitor; NAAA activity-based protein profiling (ABPP) probe | ||
| 6890 | VH 032 - linker 11 | Apr 2019 |
| VH 032-AlkylC8-Amine | ||
| 6879 | VH 032 - linker 9 | Apr 2019 |
| VH 032-PEG1-amine | ||
| 6880 | VH 032 - linker 10 | Apr 2019 |
| VH 032-alkylC10-amine | ||
| 6865 | uPSEM 792 hydrochloride | Apr 2019 |
| Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant | ||
| 6818 | Artemether | Mar 2019 |
| Antimalarial; also inhibits neuroinflammation | ||
| 6784 | FTBMT | Mar 2019 |
| Potent and selective GPR52 agonist; orally bioavailable and BBB permeable | ||
| 6766 | AC 1903 | Mar 2019 |
| Selective TRPC5 blocker | ||
| 6753 | CHS 828 | Mar 2019 |
| NAMPT inhibitor; active in vivo and cytotoxic | ||
| 6866 | uPSEM 817 tartrate | Mar 2019 |
| Highly potent and selective PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant | ||
| 6728 | RGFP 966 | Mar 2019 |
| Potent and selective HDAC3 inhibitor | ||
| 6787 | KI-7 | Mar 2019 |
| Positive allosteric modulator of A2B receptors | ||
| 6770 | ABT 639 | Mar 2019 |
| CaV3.2 and CaV3.1 channel blocker; orally bioavailable | ||
| 6752 | LDC 000067 | Mar 2019 |
| Potent and selective CDK9 inhibitor | ||
| 6830 | Conivaptan hydrochloride | Mar 2019 |
| Very high affinity vasopressin V1A and V2 antagonist; orally bioavailable | ||
| 6827 | Artesunate | Mar 2019 |
| Suppresses ROS-induced activation of the NLRP3 inflammasome; antimalarial | ||
| 6819 | Mefloquine hydrochloride | Mar 2019 |
| Cx36 and Cx50 gap channel blocker; also antimalarial and antischistosomal | ||
| 6706 | DPNB-ABT 594 | Mar 2019 |
| Caged ABT 594; suitable for one- or two-photon photolysis | ||
| 6490 | GNE 2861 | Mar 2019 |
| Group II PAK inhibitor; potently inhibits PAK4 and PAK 6 | ||
| 6429 | ML 210 | Mar 2019 |
| Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis | ||
| 1304 | BW-B 70C | Mar 2019 |
| 5-Lipoxygenase inhibitor | ||
| 6851 | Pomalidomide - linker 7 | Mar 2019 |
| Pomalidomide-alkylC2-amine | ||
| 6755 | Darapladib | Mar 2019 |
| Potent lp-PLA2 inhibitor | ||
| 6692 | WM 1119 | Mar 2019 |
| High affinity KAT6A (MOZ) competitive inhibitor | ||
| 6605 | dTAG-13 | Mar 2019 |
| Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation | ||
| 6664 | Kinesore | Mar 2019 |
| Kinesin-1 modulator; cell permeable | ||
| 6439 | JNJ 0966 | Mar 2019 |
| Pro-MMP9 activation inhibitor | ||
| 6272 | KYP 2047 | Mar 2019 |
| High affinity prolyl oligopeptidase inhibitor; anti-angiogenic, neuroprotective and brain penetrant | ||
| 6850 | Thalidomide - linker 6 | Mar 2019 |
| Thalidomide-alkylC2-Amine | ||
| 6834 | Auxin | Mar 2019 |
| Chemical dimerizer used in auxin-inducible degron (AID) system; phytohormone | ||
| 6760 | Raphin 1 | Mar 2019 |
| Inhibitor of the regulatory subunit PPP1R15B of protein phosphatase 1; orally bioavailable and brain penetrant | ||
| 6812 | Afatinib dimaleate | Mar 2019 |
| Potent dual specificity EGFR/HER2 inhibitor; active in vivo | ||
| 6754 | LJI308 | Mar 2019 |
| Potent pan-RSK inhibitor | ||
| 6802 | 6 TMR Tre | Feb 2019 |
| Fluorescent trehalose; selectively labels mycobacterial cell envelope | ||
| 6702 | Cerulenin | Feb 2019 |
| Irreversible fatty acid synthase inhibitor | ||
| 6518 | BI 01383298 | Feb 2019 |
| Potent and selective SLC13A5 (Na+/citrate cotransporter) inhibitor | ||
| 6798 | Click N-Acetylmuramic acid - alkyne | Feb 2019 |
| Bacterial peptidoglycan derivative; suitable for 'click'-conjugation to fluorescent dyes | ||
| 6816 | Sitagliptin phosphate | Feb 2019 |
| Potent and selective DPP IV inhibitor | ||
| 6809 | L-DON | Feb 2019 |
| Glutaminase inhibitor; also inhibits other glutamine-using enzymes and transporters | ||
| 6724 | CBA | Feb 2019 |
| Selective TRPM4 blocker | ||
| 6653 | FM19G11 | Feb 2019 |
| HIF α-subunit inhibitor | ||
| 3719 | Talabostat mesylate | Feb 2019 |
| Potent DPP IV inhibitor; activates NLRP1b inflammasome | ||
| 6759 | AA 147 | Feb 2019 |
| ER proteostasis regulator | ||
| 6786 | BzF | Feb 2019 |
| Photoreactive unnatural amino acid; photo-crosslinker | ||
| 6266 | Taxol Janelia Fluor® 646 | Feb 2019 |
| Red fluorescent taxol derivative |