Search for new products by date added, alphabetically, or by pharmacological action.
New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the New symbol.
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| Cat No | Product Name / Activity | Date Added |
|---|---|---|
| 6774 | 16673-34-0 NLRP3i | Jan 2019 |
| NLRP3 inflammasome inhibitor | ||
| 6777 | TAK 375 | Jan 2019 |
| Very high affinity and selective melatonin receptor agonist | ||
| 6726 | T-peptide | Jan 2019 |
| Cytotoxic Tau peptide; cell permeable | ||
| 6553 | JF-NP-26 | Jan 2019 |
| Caged Raseglurant | ||
| 6607 | dTRIM 24 | Jan 2019 |
| TRIM24 degrading PROTAC | ||
| 6697 | ELA-21 (human) | Jan 2019 |
| High affinity apelin receptor agonist | ||
| 6788 | Quizartinib | Jan 2019 |
| Highly potent FLT3 inhibitor | ||
| 6709 | GSK 2018682 | Jan 2019 |
| S1P1 and S1P5 agonist | ||
| 6698 | ELA-11 (human) | Jan 2019 |
| High affinity apelin receptor agonist | ||
| 5984 | LY 2955303 | Jan 2019 |
| High affinity and selective RARγ antagonist | ||
| 6334 | THDOC | Jan 2019 |
| Positive modulator of GABAA receptors; endogenous neurosteroid | ||
| 6598 | OD 36 hydrochloride | Jan 2019 |
| Potent RIPK2 inhibitor | ||
| 6606 | dBRD9 | Jan 2019 |
| Potent and selective BRD9 degrading PROTAC | ||
| 6243 | ML 385 | Jan 2019 |
| Nrf2 inhibitor; phenotypically lethal | ||
| 6699 | [D-Ala2]-GIP (human) | Jan 2019 |
| Highly potent GIP agonist | ||
| 6685 | Thalidomide, propargyl | Jan 2019 |
| Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTACs | ||
| 6682 | Pomalidomide - linker 3 | Jan 2019 |
| Pomalidomide-alkylC5-carboxylic acid | ||
| 6689 | GI 530159 | Jan 2019 |
| TREK1 and TREK2 channel activator | ||
| 6684 | VH 032 - linker 6 | Jan 2019 |
| VH 032-PEG2-alkyne | ||
| 6681 | Pomalidomide - linker 2 | Jan 2019 |
| Pomalidomide-PEG3-carboxylic acid | ||
| 6541 | AZD 2098 | Jan 2019 |
| Potent and selective CCR4 antagonist | ||
| 6369 | GNE 9278 | Jan 2019 |
| Positive allosteric modulator of NMDA receptors; acts in transmembrane domain | ||
| 6352 | (S)-ZINC 3573 | Jan 2019 |
| Negative control for (R)-ZINC 3573 | ||
| 6686 | Thalidomide - linker 5 | Jan 2019 |
| Thalidomide-PEG2-alkyne | ||
| 6683 | VH 032, propargyl | Jan 2019 |
| Alkyne-functionalized VH 032; 'click' VHL ligand for PROTACs | ||
| 6680 | VH 032 - linker 5 | Jan 2019 |
| VH 032-alkylC4-terminal carboxylic acid | ||
| 6340 | Epiblastin A | Jan 2019 |
| CK1 inhibitor; converts epiblast stem cells to ESCs and promotes ESC self-renewal | ||
| 6351 | (R)-ZINC 3573 | Jan 2019 |
| MRGPRX2 agonist | ||
| 6712 | A 77-01 | Dec 2018 |
| Potent inhibitor of TGF-βRI | ||
| 6488 | 5(6)-SFX (Fluorescein), SE | Dec 2018 |
| Green fluorescent dye for the labeling of primary amines | ||
| 6618 | MB 05032 | Dec 2018 |
| Potent FBPase inhibitor; promotes HSC expansion | ||
| 6582 | D-3 | Dec 2018 |
| Selective PSC eliminating agent | ||
| 6742 | Acetazolamide | Dec 2018 |
| Carbonic anhydrase inhibitor | ||
| 6590 | Janelia Fluor® 646, Maleimide | Dec 2018 |
| Red fluorescent dye, supplied with a maleimide reactive group | ||
| 6587 | TAK 242 | Dec 2018 |
| TLR4 signaling inhibitor | ||
| 6530 | R 121919 hydrochloride | Dec 2018 |
| High affinity CRF1 antagonist; orally bioavailable | ||
| 6579 | BAY 826 | Dec 2018 |
| Potent Tie2 inhibitor | ||
| 6676 | IC 261 | Dec 2018 |
| CK1 inhibitor; displays selectivity for CK1δ and CK1ε | ||
| 6710 | Darunavir | Dec 2018 |
| Highly potent HIV protease inhibitor | ||
| 6652 | NGI 1 | Dec 2018 |
| Oligosaccharyltransferase (OST) inhibitor; anti-flaviviral | ||
| TB4423-GMP | CHIR 99021 | Dec 2018 |
| CHIR 99021 synthesized to cGMP guidelines | ||
| 6654 | VAS 2870 | Dec 2018 |
| NADPH oxidase (Nox) inhibitor | ||
| 6625 | TFAX 594, SE | Dec 2018 |
| Red fluorescent dye; amine reactive | ||
| 6624 | TFAX 568, SE | Dec 2018 |
| Orange fluorescent dye; amine reactive | ||
| 6622 | Phalloidin-TFAX 488 | Dec 2018 |
| Green fluorescent cytoskeletal stain; binds F-actin | ||
| 5782 | Phalloidin-FITC | Dec 2018 |
| Green fluorescent cytoskeleton stain | ||
| 5496 | LP 99 | Dec 2018 |
| Selective BRD7 and BRD9 inhibitor | ||
| 6279 | JNJ 39758979 dihydrochloride | Dec 2018 |
| High affinity and selective histamine H4 receptor antagonist; orally bioavailable | ||
| 6177 | AZ 13705339 | Dec 2018 |
| Highly potent PAK1 and PAK2 inhibitor | ||
| 5497 | ent-LP 99 | Dec 2018 |
| Negative Control for LP 99 | ||
| 5783 | Phalloidin-TRITC | Dec 2018 |
| Red-orange fluorescent cytoskeleton stain | ||
| 6704 | Indo 1AM | Nov 2018 |
| Fluorescent Ca2+ indicator | ||
| 6651 | (2R/S)-6-PNG | Nov 2018 |
| Cav3.2 (T-type) Ca2+ channel blocker; active in vivo | ||
| 6640 | ReZolve-ER™ | Nov 2018 |
| Fluorescent ER and plasma membrane stain | ||
| 6626 | AP C5 | Nov 2018 |
| Potent and selective PKG2 inhibitor | ||
| 6503 | Janelia Fluor® 549, free acid | Nov 2018 |
| Yellow fluorescent dye; supplied as a free acid | ||
| 6580 | PKUMDL WQ 2101 | Nov 2018 |
| Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH) | ||
| 6325 | TM N1324 | Nov 2018 |
| Potent and selective GPR39 agonist; orally bioavailable | ||
| 6203 | GSK 9311 hydrochloride | Nov 2018 |
| Negative control for GSK 6853 | ||
| 6534 | TH 5427 hydrochloride | Nov 2018 |
| Potent NUDT5 inhibitor | ||
| 6363 | Avagacestat | Nov 2018 |
| Highly potent γ-secretase inhibitor; orally bioavailable | ||
| 5991 | BAY 598 | Nov 2018 |
| Potent and selective SMYD2 inhibitor | ||
| 6160 | VE 821 | Nov 2018 |
| High affinity and selective ATP-competitive ATR inhibitor | ||
| 6658 | Telaprevir | Nov 2018 |
| Hepatitis C virus (HCV) protease NS3/4A inhibitor | ||
| 6669 | Gly MCA | Nov 2018 |
| FXR antagonist; selectively active in intestines; orally bioavailable | ||
| 6461 | PARPi-FL | Nov 2018 |
| Potent fluorescent PARP inhibitor; cell permeable | ||
| 6660 | Crotonic Acid | Nov 2018 |
| Enhances reprogramming to pluripotency; facilitates telomere maintenance and increases telomere length | ||
| 6645 | DJ-V 159 | Nov 2018 |
| GPRC6A agonist | ||
| TB1254-GMP | Y-27632 dihydrochloride | Nov 2018 |
| Y-27632 synthesized to cGMP guidelines | ||
| 6315 | DMNB-caged-Serine | Nov 2018 |
| Caged serine; excited by visible blue light | ||
| 6106 | T 3364366 | Nov 2018 |
| Potent and reversible fatty acid desaturase 1 inhibitor; orally bioavailable | ||
| 5494 | R 547 | Nov 2018 |
| Potent and selective cdk inhibitor; orally bioavailable | ||
| 6700 | PA Nic | Oct 2018 |
| Caged nicotine; photoactivated by one-photon and two-photon excitation | ||
| 6675 | H 151 | Oct 2018 |
| STING antagonist | ||
| 6522 | TH 1217 | Oct 2018 |
| Potent dCTP pyrophosphatase 1 inhibitor | ||
| 6198 | GSK 6853 | Oct 2018 |
| Potent and selective BRPF1 inhibitor | ||
| 6657 | PA 8 | Oct 2018 |
| PAC1 receptor antagonist | ||
| 6581 | PKUMDL WQ 2201 | Oct 2018 |
| Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH) | ||
| 6501 | Janelia Fluor® 549, Azide | Oct 2018 |
| Cell permeable yellow fluorescent dye; supplied as an azide for 'click' chemistry | ||
| 6662 | 4-Octyl itaconate | Oct 2018 |
| Nrf2 activator; cell permeable | ||
| 6443 | IU1-47 | Oct 2018 |
| Potent USP14 inhibitor | ||
| 6546 | Furanone C-30 | Oct 2018 |
| Quorum sensing inhibitor; antibacterial | ||
| 5948 | DMNPE-4 AM-caged-calcium | Oct 2018 |
| Caged calcium; cell permeable | ||
| 6568 | Dooku 1 | Oct 2018 |
| Reversibly blocks Yoda1 activity; does not affect constitutive Piezo1 activity | ||
| 6444 | MitoMark Green I | Oct 2018 |
| Green fluorescent mitochondrial stain; cell permeable | ||
| 6445 | MitoMark Red I | Oct 2018 |
| Red fluorescent mitochondrial stain; cell permeable | ||
| 6089 | Nexinhib20 | Oct 2018 |
| Rab27 inhibitor; inhibits neutrophil exocytosis; active in vivo | ||
| 5550 | E 2012 | Oct 2018 |
| γ-secretase modulator; Notch-sparing | ||
| 6353 | UoS 12258 | Oct 2018 |
| Positive allosteric modulator of AMPA receptors | ||
| 6256 | OG 488 BAPTA-1 AM | Oct 2018 |
| Cell-permeable, fluorescent Ca2+ indicator | ||
| 6319 | CBM 301940 | Oct 2018 |
| Potent malonyl-CoA decarboxylase inhibitor; orally bioavailable | ||
| 6663 | Silodosin | Oct 2018 |
| Selective α1A antagonist | ||
| 6677 | CMA | Oct 2018 |
| Murine-selective STING agonist | ||
| 6594 | GSHtracer | Oct 2018 |
| Radiometric glutathione (GSH) probe | ||
| 6321 | 10-Cl-BBQ | Oct 2018 |
| Potent aryl hydrocarbon receptor (AhR) agonist; orally bioavailable | ||
| 6477 | SAHM1 | Oct 2018 |
| Notch pathway inhibitor; prevents Notch complex assembly | ||
| 6588 | (+)-JQ1 carboxylic acid | Oct 2018 |
| Carboxylic acid-functionalized BET bromodomain inhibitor; target ligand for PROTACs | ||
| 6364 | Squarunkin A hydrochloride | Oct 2018 |
| UNC119 chaperone-cargo interaction inhibitor; disrupts Src activation | ||
| 6647 | HADA | Sep 2018 |
| Blue fluorescent D-amino acid for labeling peptidoglycans in live bacteria | ||
| 6666 | T3 | Sep 2018 |
| Thyroid hormone; also promotes differentiation of oligodendroglial precursor cells | ||
| 6646 | CDDO-Me | Sep 2018 |
| Nrf2 pathway activator; also NF-κB pathway inhibitor; inhibits IKKβ | ||
| 6584 | L-Azidohomoalanine hydrochloride | Sep 2018 |
| Unnatural amino acid for bio-orthogonal labeling of newly synthesized proteins | ||
| 6537 | UNC 2881 | Sep 2018 |
| Potent Mer kinase inhibitor | ||
| 6642 | QWF | Sep 2018 |
| MRGPRX2 antagonist; also NK1 receptor antagonist | ||
| 6615 | KCC 07 | Sep 2018 |
| MBD2 (Methyl-CpG-binding domain protein 2) inhibitor | ||
| 6585 | L-Azidonorleucine hydrochloride | Sep 2018 |
| Unnatural amino acid for bio-orthogonal or fluorescent labeling of newly synthesized proteins | ||
| 6526 | Dynarrestin | Sep 2018 |
| Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein | ||
| 6236 | O8 OGG1 Inhibitor | Sep 2018 |
| Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor | ||
| 6655 | Amifostine | Sep 2018 |
| Cytoprotectant | ||
| 6602 | 1M7 | Sep 2018 |
| Reagent for RNA SHAPE-MaP chemistry | ||
| 6576 | ABT 594 hydrochloride | Sep 2018 |
| Selective α4β2 nAChR agonist | ||
| 6589 | (+)-JQ1 PA | Sep 2018 |
| Functionalized BET bromodomain inhibitor; 'click' target ligand for PROTACs | ||
| 6531 | NLS-StAx-h | Sep 2018 |
| Wnt signaling inhibitor; inhibits β-catenin-transcription factor interactions | ||
| 6516 | EPZ 015666 | Sep 2018 |
| Potent and selective PRMT5 inhibitor | ||
| 6475 | SU 6656 | Sep 2018 |
| Potent ATP-competitive Src family kinase inhibitor; also AMPK inhibitor; cell permeable | ||
| 6126 | KRH 3955 hydrochloride | Sep 2018 |
| Highly potent CXCR4 antagonist; inhibits HIV-1 replication | ||
| 6067 | M 30 dihydrochloride | Sep 2018 |
| Potent and non-selective MAO inhibitor; also an iron chelator and antioxidant | ||
| 5957 | C3 | Sep 2018 |
| Selective microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor | ||
| 6648 | NADA-green | Sep 2018 |
| Fluorescent D-amino acid for labeling peptidoglycans in live bacteria | ||
| 6508 | GSK 1702934A | Sep 2018 |
| Potent and selective TRPC3/6 activator | ||
| 6492 | GSK'872 | Sep 2018 |
| Potent and selective RIPK3 inhibitor | ||
| 6482 | XMU MP 1 | Sep 2018 |
| Potent and selective MST1/2 inhibitor; orally bioavailable | ||
| 6254 | Flutax 2 | Sep 2018 |
| Green fluorescent taxol derivative; binds microtubules | ||
| 6257 | OG 488, SE | Sep 2018 |
| Green fluorescent dye; supplied as NHS ester | ||
| 6255 | Fluo-4 AM | Sep 2018 |
| Cell-permeable, fluorescent Ca2+ indicator | ||
| 6614 | Jedi2 | Sep 2018 |
| Piezo1 channel activator | ||
| 4970 | BMS 688521 | Sep 2018 |
| Potent inhibitor of the LFA-1/ICAM interaction | ||
| 6349 | Pelitinib | Sep 2018 |
| Potent and irreversible EGFR inhibitor; orally bioavailable | ||
| 6547 | Ambuic Acid | Aug 2018 |
| Quorum sensing inhibitor; antibacterial | ||
| 6528 | SGC AAK1 1 | Aug 2018 |
| AAK1 and BMP2K inhibitor; activates Wnt signaling | ||
| 6556 | Anti-human EGFR aptamer, Janelia Fluor® 646 conjugate | Aug 2018 |
| High affinity anti-human EGFR aptamer conjugated to Janelia Fluor® 646 | ||
| 6557 | Anti-human ErbB2 aptamer, Janelia Fluor® 646 conjugate | Aug 2018 |
| High affinity anti-human ErbB2 aptamer conjugated to Janelia Fluor® 646 | ||
| 6367 | Z 944 | Aug 2018 |
| T-type Ca2+ channel blocker | ||
| 6638 | GSK 626616 | Aug 2018 |
| Potent and selective DYRK inhibitor; orally bioavailable. | ||
| 6637 | Pomalidomide - linker 1 | Aug 2018 |
| Pomalidomide-PEG2-ethylamine | ||
| 6559 | LY 450139 | Aug 2018 |
| γ-secretase pseudo-inhibitor | ||
| 6583 | UCLA GP130 2 | Aug 2018 |
| gp130 agonist; brain penetrant and neuroprotectant | ||
| 6400 | Alsterpaullone | Aug 2018 |
| Potent cdk1 and cdk2 inhibitor; also inhibits GSK-3β and Lck | ||
| 6632 | ERGi-USU | Aug 2018 |
| Rio2 kinase (RIOK2) inhibitor; inhibits ERG protein | ||
| 6627 | Thalidomide - linker 4 | Aug 2018 |
| Thalidomide-alkylC6-amine | ||
| 6532 | THAL SNS 032 | Aug 2018 |
| Potent and selective CDK9 degrading PROTAC | ||
| 6323 | FX 1 | Aug 2018 |
| Bcl-6 inhibitor; 10-fold more potent than endogenous Bcl-6 corepressors | ||
| 6269 | JT010 | Aug 2018 |
| Potent and selective TRPA1 channel activator | ||
| 6641 | Roflumilast | Aug 2018 |
| Potent and selective PDE4 inhibitor | ||
| 4690 | Fmk | Aug 2018 |
| Irreversible ribosomal S6 kinase 1/2 inhibitor | ||
| 6229 | LP 922761 | Aug 2018 |
| Potent AAK1 inhibitor; peripherally restricted | ||
| 6539 | Obatoclax mesylate | Jul 2018 |
| Inhibitor of Bcl-2 family members; antiapoptotic | ||
| 6524 | TL 12-186 | Jul 2018 |
| Multikinase degrading PROTAC | ||
| 6525 | TL 13-27 | Jul 2018 |
| Negative control for TL 12-186 | ||
| 6426 | PSEM 89S | Jul 2018 |
| PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist | ||
| 6628 | TC E3 5032 | Jul 2018 |
| Precursor to Pomalidomide-based PROTACs | ||
| 6425 | PSEM 308 hydrochloride | Jul 2018 |
| PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist | ||
| 6555 | TokeOni | Jul 2018 |
| NIR-emission luciferin analog; orally bioavailable and brain penetrant | ||
| 6422 | DREADD agonist 21 dihydrochloride | Jul 2018 |
| Potent muscarinic DREADD agonist; water soluble version of DREADD agonist 21 (Cat. No. 5548) | ||
| 6454 | LY 2603618 | Jul 2018 |
| Potent and selective Chk1 inhibitor | ||
| 6428 | Carboprost tromethamine | Jul 2018 |
| Synthetic Prostaglandin F2α (Cat. No. 4214) analog | ||
| 6330 | AZ 5704 | Jul 2018 |
| Potent and selective ATM kinase inhibitor; orally bioavailable |