New Products

View all new products by date added

Search for new products by date added, alphabetically, or by pharmacological action.

New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the symbol.

If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.

Cat No Product Name / Activity Date Added
6363 Avagacestat Nov 2018
Highly potent γ-secretase inhibitor; orally bioavailable
6534 TH 5427 hydrochloride Nov 2018
Potent NUDT5 inhibitor
5991 BAY 598 Nov 2018
Potent and selective SMYD2 inhibitor
6160 VE 821 Nov 2018
High affinity and selective ATP-competitive ATR inhibitor
6660 Crotonic Acid Nov 2018
Enhances reprogramming to pluripotency; facilitates telomere maintenance and increases telomere length
6658 Telaprevir Nov 2018
Hepatitis C virus (HCV) protease NS3/4A inhibitor
6645 DJ-V 159 Nov 2018
GPRC6A agonist
6669 Gly MCA Nov 2018
FXR antagonist; selectively active in intestines; orally bioavailable
6461 PARPi-FL Nov 2018
Potent fluorescent PARP inhibitor; cell permeable
6106 T 3364366 Nov 2018
Potent and reversible FADS1 inhibitor; orally bioavailable
5494 R 547 Nov 2018
Potent and selective CDK inhibitor; orally bioavailable
TB1254-GMP Y-27632 dihydrochloride Nov 2018
Y-27632 synthesized to cGMP guidelines
6315 DMNB-caged-Serine Nov 2018
Caged serine; excited by visible blue light
6700 PA Nic Oct 2018
Caged nicotine; photoactivated by one-photon and two-photon excitation
6675 H 151 Oct 2018
STING antagonist
6198 GSK 6853 Oct 2018
Potent and selective BRPF1 inhibitor
6522 TH 1217 Oct 2018
Potent dCTP pyrophosphatase 1 inhibitor
6443 IU1-47 Oct 2018
Potent USP14 inhibitor
6657 PA 8 Oct 2018
PAC1 receptor antagonist
6662 4-Octyl itaconate Oct 2018
Nrf2 activator; cell permeable
6546 Furanone C-30 Oct 2018
Quorum sensing inhibitor; antibacterial
5948 DMNPE-4 AM-caged-calcium Oct 2018
Caged calcium; cell permeable
6581 PKUMDL WQ 2201 Oct 2018
Phosphoglycerate dehydrogenase (PHGDH) negative allosteric modulator
6501 Janelia Fluor® 549, Azide Oct 2018
Cell permeable yellow fluorescent dye; supplied as an azide for 'click' chemistry
6445 MitoMark Red I Oct 2018
Red fluorescent mitochondrial stain
6353 UoS 12258 Oct 2018
Positive allosteric modulator of AMPA receptors
6444 MitoMark Green I Oct 2018
Green fluorescent mitochondrial stain
6568 Dooku 1 Oct 2018
Reversibly blocks Yoda1 activity; does not affect constitutive Piezo1 activity
6319 CBM 301940 Oct 2018
Potent malonyl-CoA decarboxylase inhibitor; orally bioavailable
6089 Nexinhib20 Oct 2018
Rab27 inhibitor; inhibits neutrophil exocytosis; active in vivo
6256 OG 488 BAPTA-1 AM Oct 2018
Cell-permeable, fluorescent Ca2+ indicator
5550 E 2012 Oct 2018
γ-secretase modulator; Notch-sparing
6594 GSHtracer Oct 2018
Radiometric glutathione (GSH) probe
6677 CMA Oct 2018
Murine-selective STING agonist
6663 Silodosin Oct 2018
Selective α1A antagonist
6321 10-Cl-BBQ Oct 2018
Potent aryl hydrocarbon receptor (AhR) agonist; orally bioavailable
6364 Squarunkin A hydrochloride Oct 2018
UNC119 chaperone-cargo interaction inhibitor; disrupts Src activation
6588 (+)-JQ1 carboxylic acid Oct 2018
Carboxylic acid-functionalized BET bromodomain inhibitor
6477 SAHM1 Oct 2018
Notch pathway inhibitor; prevents Notch complex assembly
6642 QWF Sep 2018
MRGPRX2 antagonist; also NK1 receptor antagonist
6647 HADA Sep 2018
Blue fluorescent D-amino acid for labeling peptidoglycans in live bacteria
6615 KCC 07 Sep 2018
MBD2 (Methyl-CpG-binding domain protein 2) inhibitor
6646 CDDO-Me Sep 2018
Nrf2 pathway activator; also NF-κB pathway inhibitor; inhibits IKKβ
6666 T3 Sep 2018
Thyroid hormone; also promotes differentiation of oligodendroglial precursor cells
6585 L-Azidonorleucine hydrochloride Sep 2018
Unnatural amino acid for bio-orthogonal or fluorescent labeling of newly synthesized proteins
6584 L-Azidohomoalanine hydrochloride Sep 2018
Unnatural amino acid for bio-orthogonal labeling of newly synthesized proteins
6537 UNC 2881 Sep 2018
Potent Mer kinase inhibitor
6526 Dynarrestin Sep 2018
Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein
6236 O8 OGG1 Inhibitor Sep 2018
Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor
6655 Amifostine Sep 2018
Cytoprotectant
6589 (+)-JQ1 PA Sep 2018
'Click' target ligand for PROTACs; functionalized BET bromodomain inhibitor
6602 1M7 Sep 2018
Reagent for RNA SHAPE-MaP chemistry
6576 ABT 594 hydrochloride Sep 2018
Selective α4β2 nAChR agonist
6531 NLS-StAx-h Sep 2018
Wnt signaling inhibitor; inhibits β-catenin-transcription factor interactions
6067 M 30 dihydrochloride Sep 2018
Potent and non-selective MAO inhibitor; also an iron chelator and antioxidant
6126 KRH 3955 hydrochloride Sep 2018
Highly potent CXCR4 antagonist; inhibits HIV-1 replication
5957 C3 Sep 2018
Selective microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor
6516 EPZ 015666 Sep 2018
Potent and selective PRMT5 inhibitor
6475 SU 6656 Sep 2018
Potent ATP-competitive Src family kinase inhibitor; also AMPK inhibitor; cell permeable
6648 NADA-green Sep 2018
Fluorescent D-amino acid for labeling peptidoglycans in live bacteria
6255 Fluo-4 AM Sep 2018
Cell-permeable, fluorescent Ca2+ indicator
6508 GSK 1702934A Sep 2018
Potent and selective TRPC3/6 activator
6492 GSK'872 Sep 2018
Potent and selective receptor activating protein kinase 3 (RIP3) inhibitor
6482 XMU MP 1 Sep 2018
Potent and selective MST1/2 inhibitor; orally bioavailable
6257 OG 488, SE Sep 2018
Green fluorescent dye; supplied as NHS ester
6254 Flutax 2 Sep 2018
Green fluorescent taxol derivative
6349 Pelitinib Sep 2018
Potent and irreversible EGFR inhibitor; orally bioavailable
6614 Jedi2 Sep 2018
Piezo1 channel activator
4970 BMS 688521 Sep 2018
Potent inhibitor of the LFA-1/ICAM interaction
6367 Z 944 Aug 2018
Ca2+ channel blocker (T-type)
6556 Anti-human EGFR aptamer, Janelia Fluor® 646 conjugate Aug 2018
High affinity anti-human EGFR aptamer conjugated to Janelia Fluor® 646
6547 Ambuic Acid Aug 2018
Quorum sensing inhibitor; antibacterial
6557 Anti-human ErbB2 aptamer, Janelia Fluor® 646 conjugate Aug 2018
High affinity anti-human ErbB2 aptamer conjugated to Janelia Fluor® 646
6528 SGC AAK1 1 Aug 2018
AAK1 and BMP2K inhibitor; activates Wnt signaling
6400 Alsterpaullone Aug 2018
Potent CDK1 and 2 inhibitor; also inhibits GSK-3β and Lck
6637 Pomalidomide - linker 1 Aug 2018
Pomalidomide-PEG2-ethylamine
6638 GSK 626616 Aug 2018
Potent and selective DYRK inhibitor; orally bioavailable.
6627 Thalidomide - linker 4 Aug 2018
Thalidomide-alkylC6-amine
6632 ERGi-USU Aug 2018
Rio2 kinase (RIOK2) inhibitor; inhibits ERG protein
6583 UCLA GP130 2 Aug 2018
gp130 agonist; brain penetrant and neuroprotectant
6559 LY 450139 Aug 2018
γ-secretase pseudo-inhibitor
6269 JT010 Aug 2018
Potent and selective TRPA1 channel activator
6532 THAL SNS 032 Aug 2018
Potent and selective CDK9 degrading PROTAC
6323 FX 1 Aug 2018
BCL6 inhibitor; 10-fold more potent than endogenous BCL6 corepressors
6641 Roflumilast Aug 2018
Potent and selective PDE4 inhibitor
6229 LP 922761 Aug 2018
Potent AAK1 inhibitor; peripherally restricted
4690 Fmk Aug 2018
Irreversible ribosomal S6 kinase inhibitor 1/2 inhibitor
6425 PSEM 308 hydrochloride Jul 2018
PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist
6428 Carboprost tromethamine Jul 2018
Synthetic Prostaglandin F (Cat. No. 4214) analog
6454 LY 2603618 Jul 2018
Potent and selective Chk1 inhibitor
6426 PSEM 89S Jul 2018
PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist
6422 DREADD agonist 21 dihydrochloride Jul 2018
Potent muscarinic DREADD agonist; water soluble version of DREADD agonist 21 (Cat. No. 5548)
6628 TC E3 5032 Jul 2018
Precursor to Pomalidomide-based PROTACs
6525 TL 13-27 Jul 2018
Negative control for TL 12-186
6555 TokeOni Jul 2018
NIR-emission luciferin analog; orally bioavailable and brain penetrant
6539 Obatoclax mesylate Jul 2018
Inhibitor of Bcl-2 family members; antiapoptotic
6524 TL 12-186 Jul 2018
Multikinase degrading PROTAC
6330 AZ 5704 Jul 2018
Potent and selective ATM kinase inhibitor; orally bioavailable
6483 Isoginkgetin Jul 2018
Pre-mRNA splicing inhibitor; cell permeable
4007 Laulimalide Jul 2018
Microtubule stabilzing agent
5910 TL4-12 Jul 2018
Potent MAP4K2 (GCK) inhibitor
TB2634-GMP DAPT Jul 2018
DAPT synthesized to cGMP guidelines
TB1614-GMP SB 431542 Jul 2018
SB 431542 synthesized to cGMP guidelines
6545 OB-1 Jul 2018
Stomatin-like protein-3 (STOML3) oligomerization inhibitor
6153 JQEZ5 Jul 2018
Potent and selective SAM-competitive EZH2 inhibitor
6542 Ivabradine hydrochloride Jul 2018
HCN channel blocker; inhibits If pacemaker current
6538 PF 04449913 maleate Jul 2018
Potent Smo antagonist
6520 Abiraterone acetate Jul 2018
Potent CYP17A1 inhibitor
6506 PF 06551600 malonate Jul 2018
Potent and selective JAK3 inhibitor
6479 CU CPT 9a Jul 2018
Potent TLR8 inhibitor
6199 BAY 876 Jul 2018
Potent and selective GLUT1 inhibitor
6517 Liraglutide Jul 2018
Highly potent, long-acting GLP-1 receptor agonist
6480 GSK 583 Jul 2018
Potent RIP2 kinase inhibitor; orally bioavailable and cell permeable
6476 Compound E Jul 2018
γ-secretase inhibitor; induces neuronal differentiation
6486 Aprepitant Jul 2018
Potent long-acting hNK-1 antagonist
6491 YM 155 Jul 2018
Survivin suppressor
6544 CID 1375606 Jul 2018
GPR27 agonist
6436 CY 09 Jul 2018
NLRP3 inhibitor; active in vivo
6578 GT 949 Jul 2018
Potent and selective positive allosteric modulator of EAAT2
6324 Autophinib Jul 2018
Potent VPS34 inhibitor
6281 SLM 6031434 hydrochloride Jul 2018
Selective sphingosine kinase 2 (Sphk2) inhibitor
6273 CRT 0105950 Jul 2018
Potent LIMK1/2 inhibitor
5767 SR 3029 Jul 2018
Potent and selective CK1δ and CK1ε inhibitor
6564 SGC GAK 1 Jul 2018
High affinity cyclin G associated kinase (GAK) inhibitor
6558 CP 43 Jul 2018
Potent TAOK inhibitor
6320 ESI 05 Jul 2018
Epac2 inhibitor
6179 UK 59811 hydrochloride Jul 2018
CaVAb blocker
6040 BRD 9757 Jul 2018
Potent and selective HDAC6 inhibitor
6239 SAK 3 Jul 2018
Potent CaV3.1/3.3 activator; orally bioavailable
6448 ML 351 Jun 2018
Selective 12/15 LOX inhibitor; active in vivo
6554 (+)-Abscisic Acid Jun 2018
Endogenous LANCL2 agonist
6037 LM22B 10 Jun 2018
TrkB and TrkC agonist; brain penetrant
6144 CX08005 Jun 2018
Competitive PTP1B inhibitor
5828 Ambrisentan Jun 2018
Selective ETA antagonist
6505 Avasimibe Jun 2018
ACAT inhibitor
6079 TC KHNS 11 Jun 2018
Potent and selective PI 3-kinase δ inhibitor; orally bioavailable
6406 Hydroxystilbamidine bis(methanesulfonate) Jun 2018
Fluorescent cationic dye; neuronal tracer
6572 Biotin-LC-NAD+ Jun 2018
Biotinylated analog of β-NAD+; commonly used reagent in LSD1 and PARP1 assays
6549 cAC 253 Jun 2018
Amylin (AMY3) receptor antagonist; brain penetrant
6296 Janelia Fluor® 525, SE Jun 2018
Cell permeable yellow fluorescent dye; supplied as NHS ester
6571 Biotin-11-dUTP Jun 2018
Biotin-labeled dUTP
6552 PAMP-20 (human) Jun 2018
MRGPRX2 agonist
6113 Liproxstatin-1 hydrochloride Jun 2018
Potent ferroptosis inhibitor
6551 PAMP-12 (human, porcine) Jun 2018
Potent MRGPRX2 agonist
6548 N-(3-Oxododecanoyl)-L-homoserine lactone May 2018
Bacterial quorum sensing autoinducer; immunomodulator
6550 AC 253 May 2018
Amylin (AMY3) receptor antagonist
6244 OG-L002 May 2018
Potent LSD1 inhibitor
6017 THPN May 2018
Nur77 agonist; induces autophagy in melanoma cell lines