New Products

View all new products by date added

Search for new products by date added, alphabetically, or by pharmacological action.

New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the symbol.

If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.

Cat No Product Name / Activity Date Added
6774 16673-34-0 NLRP3i Jan 2019
NLRP3 inflammasome inhibitor
6777 TAK 375 Jan 2019
Very high affinity and selective melatonin receptor agonist
6726 T-peptide Jan 2019
Cytotoxic Tau peptide; cell permeable
6553 JF-NP-26 Jan 2019
Caged Raseglurant
6607 dTRIM 24 Jan 2019
TRIM24 degrading PROTAC
6697 ELA-21 (human) Jan 2019
High affinity apelin receptor agonist
6788 Quizartinib Jan 2019
Highly potent FLT3 inhibitor
6709 GSK 2018682 Jan 2019
S1P1 and S1P5 agonist
6698 ELA-11 (human) Jan 2019
High affinity apelin receptor agonist
5984 LY 2955303 Jan 2019
High affinity and selective RARγ antagonist
6334 THDOC Jan 2019
Positive modulator of GABAA receptors; endogenous neurosteroid
6598 OD 36 hydrochloride Jan 2019
Potent RIPK2 inhibitor
6606 dBRD9 Jan 2019
Potent and selective BRD9 degrading PROTAC
6243 ML 385 Jan 2019
Nrf2 inhibitor; phenotypically lethal
6699 [D-Ala2]-GIP (human) Jan 2019
Highly potent GIP agonist
6685 Thalidomide, propargyl Jan 2019
Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTACs
6682 Pomalidomide - linker 3 Jan 2019
Pomalidomide-alkylC5-carboxylic acid
6689 GI 530159 Jan 2019
TREK1 and TREK2 channel activator
6684 VH 032 - linker 6 Jan 2019
VH 032-PEG2-alkyne
6681 Pomalidomide - linker 2 Jan 2019
Pomalidomide-PEG3-carboxylic acid
6541 AZD 2098 Jan 2019
Potent and selective CCR4 antagonist
6369 GNE 9278 Jan 2019
Positive allosteric modulator of NMDA receptors; acts in transmembrane domain
6352 (S)-ZINC 3573 Jan 2019
Negative control for (R)-ZINC 3573
6686 Thalidomide - linker 5 Jan 2019
Thalidomide-PEG2-alkyne
6683 VH 032, propargyl Jan 2019
Alkyne-functionalized VH 032; 'click' VHL ligand for PROTACs
6680 VH 032 - linker 5 Jan 2019
VH 032-alkylC4-terminal carboxylic acid
6340 Epiblastin A Jan 2019
CK1 inhibitor; converts epiblast stem cells to ESCs and promotes ESC self-renewal
6351 (R)-ZINC 3573 Jan 2019
MRGPRX2 agonist
6712 A 77-01 Dec 2018
Potent inhibitor of TGF-βRI
6488 5(6)-SFX (Fluorescein), SE Dec 2018
Green fluorescent dye for the labeling of primary amines
6618 MB 05032 Dec 2018
Potent FBPase inhibitor; promotes HSC expansion
6582 D-3 Dec 2018
Selective PSC eliminating agent
6742 Acetazolamide Dec 2018
Carbonic anhydrase inhibitor
6590 Janelia Fluor® 646, Maleimide Dec 2018
Red fluorescent dye, supplied with a maleimide reactive group
6587 TAK 242 Dec 2018
TLR4 signaling inhibitor
6530 R 121919 hydrochloride Dec 2018
High affinity CRF1 antagonist; orally bioavailable
6579 BAY 826 Dec 2018
Potent Tie2 inhibitor
6676 IC 261 Dec 2018
CK1 inhibitor; displays selectivity for CK1δ and CK1ε
6710 Darunavir Dec 2018
Highly potent HIV protease inhibitor
6652 NGI 1 Dec 2018
Oligosaccharyltransferase (OST) inhibitor; anti-flaviviral
TB4423-GMP CHIR 99021 Dec 2018
CHIR 99021 synthesized to cGMP guidelines
6654 VAS 2870 Dec 2018
NADPH oxidase (Nox) inhibitor
6625 TFAX 594, SE Dec 2018
Red fluorescent dye; amine reactive
6624 TFAX 568, SE Dec 2018
Orange fluorescent dye; amine reactive
6622 Phalloidin-TFAX 488 Dec 2018
Green fluorescent cytoskeletal stain; binds F-actin
5782 Phalloidin-FITC Dec 2018
Green fluorescent cytoskeleton stain
5496 LP 99 Dec 2018
Selective BRD7 and BRD9 inhibitor
6279 JNJ 39758979 dihydrochloride Dec 2018
High affinity and selective histamine H4 receptor antagonist; orally bioavailable
6177 AZ 13705339 Dec 2018
Highly potent PAK1 and PAK2 inhibitor
5497 ent-LP 99 Dec 2018
Negative Control for LP 99
5783 Phalloidin-TRITC Dec 2018
Red-orange fluorescent cytoskeleton stain
6704 Indo 1AM Nov 2018
Fluorescent Ca2+ indicator
6651 (2R/S)-6-PNG Nov 2018
Cav3.2 (T-type) Ca2+ channel blocker; active in vivo
6640 ReZolve-ER™ Nov 2018
Fluorescent ER and plasma membrane stain
6626 AP C5 Nov 2018
Potent and selective PKG2 inhibitor
6503 Janelia Fluor® 549, free acid Nov 2018
Yellow fluorescent dye; supplied as a free acid
6580 PKUMDL WQ 2101 Nov 2018
Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)
6325 TM N1324 Nov 2018
Potent and selective GPR39 agonist; orally bioavailable
6203 GSK 9311 hydrochloride Nov 2018
Negative control for GSK 6853
6534 TH 5427 hydrochloride Nov 2018
Potent NUDT5 inhibitor
6363 Avagacestat Nov 2018
Highly potent γ-secretase inhibitor; orally bioavailable
5991 BAY 598 Nov 2018
Potent and selective SMYD2 inhibitor
6160 VE 821 Nov 2018
High affinity and selective ATP-competitive ATR inhibitor
6658 Telaprevir Nov 2018
Hepatitis C virus (HCV) protease NS3/4A inhibitor
6669 Gly MCA Nov 2018
FXR antagonist; selectively active in intestines; orally bioavailable
6461 PARPi-FL Nov 2018
Potent fluorescent PARP inhibitor; cell permeable
6660 Crotonic Acid Nov 2018
Enhances reprogramming to pluripotency; facilitates telomere maintenance and increases telomere length
6645 DJ-V 159 Nov 2018
GPRC6A agonist
TB1254-GMP Y-27632 dihydrochloride Nov 2018
Y-27632 synthesized to cGMP guidelines
6315 DMNB-caged-Serine Nov 2018
Caged serine; excited by visible blue light
6106 T 3364366 Nov 2018
Potent and reversible fatty acid desaturase 1 inhibitor; orally bioavailable
5494 R 547 Nov 2018
Potent and selective cdk inhibitor; orally bioavailable
6700 PA Nic Oct 2018
Caged nicotine; photoactivated by one-photon and two-photon excitation
6675 H 151 Oct 2018
STING antagonist
6522 TH 1217 Oct 2018
Potent dCTP pyrophosphatase 1 inhibitor
6198 GSK 6853 Oct 2018
Potent and selective BRPF1 inhibitor
6657 PA 8 Oct 2018
PAC1 receptor antagonist
6581 PKUMDL WQ 2201 Oct 2018
Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)
6501 Janelia Fluor® 549, Azide Oct 2018
Cell permeable yellow fluorescent dye; supplied as an azide for 'click' chemistry
6662 4-Octyl itaconate Oct 2018
Nrf2 activator; cell permeable
6443 IU1-47 Oct 2018
Potent USP14 inhibitor
6546 Furanone C-30 Oct 2018
Quorum sensing inhibitor; antibacterial
5948 DMNPE-4 AM-caged-calcium Oct 2018
Caged calcium; cell permeable
6568 Dooku 1 Oct 2018
Reversibly blocks Yoda1 activity; does not affect constitutive Piezo1 activity
6444 MitoMark Green I Oct 2018
Green fluorescent mitochondrial stain; cell permeable
6445 MitoMark Red I Oct 2018
Red fluorescent mitochondrial stain; cell permeable
6089 Nexinhib20 Oct 2018
Rab27 inhibitor; inhibits neutrophil exocytosis; active in vivo
5550 E 2012 Oct 2018
γ-secretase modulator; Notch-sparing
6353 UoS 12258 Oct 2018
Positive allosteric modulator of AMPA receptors
6256 OG 488 BAPTA-1 AM Oct 2018
Cell-permeable, fluorescent Ca2+ indicator
6319 CBM 301940 Oct 2018
Potent malonyl-CoA decarboxylase inhibitor; orally bioavailable
6663 Silodosin Oct 2018
Selective α1A antagonist
6677 CMA Oct 2018
Murine-selective STING agonist
6594 GSHtracer Oct 2018
Radiometric glutathione (GSH) probe
6321 10-Cl-BBQ Oct 2018
Potent aryl hydrocarbon receptor (AhR) agonist; orally bioavailable
6477 SAHM1 Oct 2018
Notch pathway inhibitor; prevents Notch complex assembly
6588 (+)-JQ1 carboxylic acid Oct 2018
Carboxylic acid-functionalized BET bromodomain inhibitor; target ligand for PROTACs
6364 Squarunkin A hydrochloride Oct 2018
UNC119 chaperone-cargo interaction inhibitor; disrupts Src activation
6647 HADA Sep 2018
Blue fluorescent D-amino acid for labeling peptidoglycans in live bacteria
6666 T3 Sep 2018
Thyroid hormone; also promotes differentiation of oligodendroglial precursor cells
6646 CDDO-Me Sep 2018
Nrf2 pathway activator; also NF-κB pathway inhibitor; inhibits IKKβ
6584 L-Azidohomoalanine hydrochloride Sep 2018
Unnatural amino acid for bio-orthogonal labeling of newly synthesized proteins
6537 UNC 2881 Sep 2018
Potent Mer kinase inhibitor
6642 QWF Sep 2018
MRGPRX2 antagonist; also NK1 receptor antagonist
6615 KCC 07 Sep 2018
MBD2 (Methyl-CpG-binding domain protein 2) inhibitor
6585 L-Azidonorleucine hydrochloride Sep 2018
Unnatural amino acid for bio-orthogonal or fluorescent labeling of newly synthesized proteins
6526 Dynarrestin Sep 2018
Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein
6236 O8 OGG1 Inhibitor Sep 2018
Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor
6655 Amifostine Sep 2018
Cytoprotectant
6602 1M7 Sep 2018
Reagent for RNA SHAPE-MaP chemistry
6576 ABT 594 hydrochloride Sep 2018
Selective α4β2 nAChR agonist
6589 (+)-JQ1 PA Sep 2018
Functionalized BET bromodomain inhibitor; 'click' target ligand for PROTACs
6531 NLS-StAx-h Sep 2018
Wnt signaling inhibitor; inhibits β-catenin-transcription factor interactions
6516 EPZ 015666 Sep 2018
Potent and selective PRMT5 inhibitor
6475 SU 6656 Sep 2018
Potent ATP-competitive Src family kinase inhibitor; also AMPK inhibitor; cell permeable
6126 KRH 3955 hydrochloride Sep 2018
Highly potent CXCR4 antagonist; inhibits HIV-1 replication
6067 M 30 dihydrochloride Sep 2018
Potent and non-selective MAO inhibitor; also an iron chelator and antioxidant
5957 C3 Sep 2018
Selective microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor
6648 NADA-green Sep 2018
Fluorescent D-amino acid for labeling peptidoglycans in live bacteria
6508 GSK 1702934A Sep 2018
Potent and selective TRPC3/6 activator
6492 GSK'872 Sep 2018
Potent and selective RIPK3 inhibitor
6482 XMU MP 1 Sep 2018
Potent and selective MST1/2 inhibitor; orally bioavailable
6254 Flutax 2 Sep 2018
Green fluorescent taxol derivative; binds microtubules
6257 OG 488, SE Sep 2018
Green fluorescent dye; supplied as NHS ester
6255 Fluo-4 AM Sep 2018
Cell-permeable, fluorescent Ca2+ indicator
6614 Jedi2 Sep 2018
Piezo1 channel activator
4970 BMS 688521 Sep 2018
Potent inhibitor of the LFA-1/ICAM interaction
6349 Pelitinib Sep 2018
Potent and irreversible EGFR inhibitor; orally bioavailable
6547 Ambuic Acid Aug 2018
Quorum sensing inhibitor; antibacterial
6528 SGC AAK1 1 Aug 2018
AAK1 and BMP2K inhibitor; activates Wnt signaling
6556 Anti-human EGFR aptamer, Janelia Fluor® 646 conjugate Aug 2018
High affinity anti-human EGFR aptamer conjugated to Janelia Fluor® 646
6557 Anti-human ErbB2 aptamer, Janelia Fluor® 646 conjugate Aug 2018
High affinity anti-human ErbB2 aptamer conjugated to Janelia Fluor® 646
6367 Z 944 Aug 2018
T-type Ca2+ channel blocker
6638 GSK 626616 Aug 2018
Potent and selective DYRK inhibitor; orally bioavailable.
6637 Pomalidomide - linker 1 Aug 2018
Pomalidomide-PEG2-ethylamine
6559 LY 450139 Aug 2018
γ-secretase pseudo-inhibitor
6583 UCLA GP130 2 Aug 2018
gp130 agonist; brain penetrant and neuroprotectant
6400 Alsterpaullone Aug 2018
Potent cdk1 and cdk2 inhibitor; also inhibits GSK-3β and Lck
6632 ERGi-USU Aug 2018
Rio2 kinase (RIOK2) inhibitor; inhibits ERG protein
6627 Thalidomide - linker 4 Aug 2018
Thalidomide-alkylC6-amine
6532 THAL SNS 032 Aug 2018
Potent and selective CDK9 degrading PROTAC
6323 FX 1 Aug 2018
Bcl-6 inhibitor; 10-fold more potent than endogenous Bcl-6 corepressors
6269 JT010 Aug 2018
Potent and selective TRPA1 channel activator
6641 Roflumilast Aug 2018
Potent and selective PDE4 inhibitor
4690 Fmk Aug 2018
Irreversible ribosomal S6 kinase 1/2 inhibitor
6229 LP 922761 Aug 2018
Potent AAK1 inhibitor; peripherally restricted
6539 Obatoclax mesylate Jul 2018
Inhibitor of Bcl-2 family members; antiapoptotic
6524 TL 12-186 Jul 2018
Multikinase degrading PROTAC
6525 TL 13-27 Jul 2018
Negative control for TL 12-186
6426 PSEM 89S Jul 2018
PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist
6628 TC E3 5032 Jul 2018
Precursor to Pomalidomide-based PROTACs
6425 PSEM 308 hydrochloride Jul 2018
PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist
6555 TokeOni Jul 2018
NIR-emission luciferin analog; orally bioavailable and brain penetrant
6422 DREADD agonist 21 dihydrochloride Jul 2018
Potent muscarinic DREADD agonist; water soluble version of DREADD agonist 21 (Cat. No. 5548)
6454 LY 2603618 Jul 2018
Potent and selective Chk1 inhibitor
6428 Carboprost tromethamine Jul 2018
Synthetic Prostaglandin F (Cat. No. 4214) analog
6330 AZ 5704 Jul 2018
Potent and selective ATM kinase inhibitor; orally bioavailable