- Cell Biology
- Product Type
- Research Area
- New Products
- About Tocris
- Contact Us
Tocris is proud to offer free scientific posters and reviews, all written by experts in their fields. We also produce in-house product guides, which give an overview of how our products are used in many research areas including stem cells, neuroscience and cancer, among others. Please request a free copy or download the PDF today!
Tocris Biosciences’ catalog comprises over 4500 products covering research areas including neuroscience, cancer, endocrinology, pain and inflammation, cardiovascular, immunology, respiratory system, stem cells and cell and gene therapy.
Tocris has a dedicated team of PhD qualified product managers who assess all the latest tools and technologies, adding around 400 products every year. View the latest ranges in our portfolio .
Janelia Fluor® dyes are innovative small molecule fluorophores, which are very bright and photostable and importantly, they are cell-permeable, enabling live-cell intracellular imaging. Janelia Fluor® dyes are supplied with a number of reactivity groups including as free acid, maleimide, tetrazine and NHS esters, allowing for easy conjugation to antibodies (protocols available). The amine reactive versions are compatible with self-labeling tag systems. Janelia Fluor® dyes are suitable for use with both conventional imaging and super resolution microscopy (SRM) techniques, including dSTORM. In addition, photoactivatable derivatives have been developed that are applicable in PALM microscopy too. Our Janelia Fluor® range spans the color spectrum from the green/yellow Janelia Fluor® 525, to the far red Janelia Fluor® 669.
We also offer Janelia Fluor® conjugated antibodies and custom conjugation services with our sister company Novus Biologicals. Multiplex experiments can be planned on our spectra viewer.
Application of Janelia Fluor® Dyes in Cardiac Tissue - Left - displaying the distribution of collagen VI in the interstitial space between muscle cells. Labeled with a primary ab against collagen VI and a secondary ab conjugated to JF549 (#6147). Scale: 50 μm. Middle - An adult pig heart tissue section, 10 μm thick, labeled with abs against SERCA2ATPase, displays sarcoplasmic reticulum. Top: super-resolution image (dSTORM), bottom: diffraction limited widefield image. Scale: 200 nm. Right - Cardiomyocyte stained against α-actinin, displaying its periodic structure localised at the ends of sarcomeres (Z-discs). (left) Widefield fluorescence of JF549 (right) dSTORM super-resolution image (right). Scale: 1 μm.
All images kindly provided by Prof. Christian Soeller, University of Exeter; acquired by Alex Clowsley and Anna Meletiou