Pricing Availability   Qty
Description: Dynamin-related protein 1 (Drp1) inhibitor; cell-permeable
Purity: ≥95% (HPLC)

Biological Activity for P110

P110 is a dynamin-related protein 1 (Drp1) inhibitor, inhibits Drp1 GTPase activity. Displays no effect on dynamin 1 or other mitochondrial dynamics-related proteins. Inhibits mitochondrial fission, dysfunction and reactive oxygen species (ROS) production in vitro. Reduces programmed cell death and improves cell viability by protecting mitochondrial integrity. Reduces mitochondrial fragmentation and mitochondrial ROS production in mouse model of Parkinson's disease. Cell permeable.

Technical Data for P110

M. Wt 2411.8
Formula C100H179N45O25

(Modification: Ser-20 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2770267-63-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for P110

Solubility Soluble to 1 mg/ml in water

Product Datasheets for P110

Certificate of Analysis / Product Datasheet
Select another batch:

References for P110

References are publications that support the biological activity of the product.

Qi et al (2013) A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J.Cell Sci. 126 789 PMID: 23239023

Filichia et al (2016) Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson's disease model induced by MPTP. Sci.Rep. 13 32656 PMID: 27619562

If you know of a relevant reference for P110, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Dynamin Inhibitors

Keywords: P110, P110 supplier, dynamin, related, protein, 1, inhibitors, inhibits, mitochondrial, fission, dysfunction, mitochondria, Dynamin, 6897, Tocris Bioscience

Citations for P110

Citations are publications that use Tocris products.

Currently there are no citations for P110. Do you know of a great paper that uses P110 from Tocris? Please let us know.

Reviews for P110

There are currently no reviews for this product. Be the first to review P110 and earn rewards!

Have you used P110?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review