P110

Pricing Availability   Qty
Cat.No. 6897 - P110 | Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Asp-Leu-Leu-Pro-Arg-Gly-Ser-NH2
Description: Dynamin-related protein 1 (Drp1) inhibitor; cell-permeable
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Dynamin-related protein 1 (Drp1) inhibitor, inhibits Drp1 GTPase activity. Displays no effect on dynamin 1 or other mitochondrial dynamics-related proteins. Inhibits mitochondrial fission, dysfunction and reactive oxygen species (ROS) production in vitro. Reduces programmed cell death and improves cell viability by protecting mitochondrial integrity. Reduces mitochondrial fragmentation and mitochondrial ROS production in mouse model of Parkinson's disease. Cell permeable.

Technical Data

M. Wt 2411.8
Formula C100H179N45O25
Sequence YGRKKRRQRRRGGDLLPRGS

(Modifications: Ser-20 = C-terminal amide)

Storage Store at -20°C
InChI Key TYQHBBMTJWPEDH-VZOPDNRXSA-N
Smiles [H]N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCC(N[C@H](C(N)=O)CO)=O)=O)CCCNC(N)=N)=O)=O)CC(C)C)=O)CC(C)C)=O)CC(O)=O)=O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCCN)=O)CCCNC(N)=N)=O)=O)CC2=CC=C(C=C2)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

References

References are publications that support the biological activity of the product.

Qi et al (2013) A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J.Cell Sci. 126 789 PMID: 23239023

Filichia et al (2016) Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson's disease model induced by MPTP. Sci.Rep. 13 32656 PMID: 27619562


If you know of a relevant reference for P110, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Dynamin Inhibitors

Keywords: P110, P110 supplier, dynamin, related, protein, 1, inhibitors, inhibits, mitochondrial, fission, dysfunction, mitochondria, Dynamin, 6897, Tocris Bioscience

Citations for P110

Citations are publications that use Tocris products.

Currently there are no citations for P110. Do you know of a great paper that uses P110 from Tocris? Please let us know.

Reviews for P110

There are currently no reviews for this product. Be the first to review P110 and earn rewards!

Have you used P110?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide [Spring/Summer 2019]

Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Chemogenetics
  • Epigenetics
  • Fluorescent Imaging
  • PROTACs
  • Signal Transduction
  • Stem Cells