VU 0134992

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Cat.No. 6877 - VU 0134992 | C20H31BrN2O2 | CAS No. 755002-90-5
Description: Kir4.1 blocker
Chemical Name: 2-(2-Bromo-4-isopropylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Kir4.1 potassium channel blocker (IC50 = 0.97 μM). Displays 10-fold selectivity for Kir4.1 over Kir4.1/5.1 concatemeric channels and >30-fold selectivity over Kir1.1, 2.1 and 2.2. Increases urine output and urinary Na+ and K+ excretion in volume-loaded rats.

Technical Data

M. Wt 411.38
Formula C20H31BrN2O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 755002-90-5
PubChem ID 1319582
InChI Key OTTDLWFVHQYRDA-UHFFFAOYSA-N
Smiles CC(C)C1=CC(Br)=C(OCC(=O)NC2CC(C)(C)NC(C)(C)C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.14 100
ethanol 41.14 100

Preparing Stock Solutions

The following data is based on the product molecular weight 411.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.15 mL 24.31 mL
5 mM 0.49 mL 2.43 mL 4.86 mL
10 mM 0.24 mL 1.22 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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References

References are publications that support the biological activity of the product.

Kharade et al (2018) Discovery, characterization, and effects on renal fluid and electrolyte excretion of the Kir4.1 potassium channel pore blocker, VU0134992. Mol.Pharmacol. 94 926 PMID: 29895592


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Citations for VU 0134992

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