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Kir7.1 inhibitor (IC50 = 0.31 μM). Also inhibits Kir6.2 with similar potency. Displays >17-fold selectivity for Kir7.1 over Kir1.1, Kir2.1, Kir2.2, Kir2.3, Kir3.1/3.2 and Kir4.1. Active in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 377.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||13.23 mL||66.16 mL||132.32 mL|
|1 mM||2.65 mL||13.23 mL||26.46 mL|
|2 mM||1.32 mL||6.62 mL||13.23 mL|
|10 mM||0.26 mL||1.32 mL||2.65 mL|
References are publications that support the biological activity of the product.
Swale et al (2016) ML418: the first selective, sub-micromolar pore blocker of Kir7.1 potassium channels. ACS Chem.Neurosci. 7 1013 PMID: 27184474
Kharade (2017) Pore polarity and charge determine differential block of Kir1.1 and Kir7.1 potassium channels by small-molecule inhibitor VU590. Mol.Pharmacol. 92 338 PMID: 28619748
If you know of a relevant reference for ML 418, please let us know.
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Keywords: ML 418, ML 418 supplier, ML418, inward-rectifier, potassium, channels, Kir, 7.1, 6.2, inhibitors, inhibits, active, in, vivo, Inward, rectifier, Potassium, Channels, 6889, Tocris Bioscience
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