ML 418

Pricing Availability   Qty
Description: Kir 7.1 inhibitor; also inhibits Kir 6.2
Chemical Name: Isopropyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl)piperidin-4-yl)carbamate
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for ML 418

ML 418 is a Kir7.1 inhibitor (IC50 = 0.31 μM). Also inhibits Kir6.2 with similar potency. Displays >17-fold selectivity for Kir7.1 over Kir1.1, Kir2.1, Kir2.2, Kir2.3, Kir3.1/3.2 and Kir4.1. Active in vivo.

Compound Libraries for ML 418

ML 418 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 418

M. Wt 377.87
Formula C19H24CIN3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1928763-08-9
PubChem ID 91667465
Smiles CC(OC(NC1CCN(CC1)CC2=C(C3=C(C(Cl)=C2)C=CC=N3)O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 418

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 7.56 20

Preparing Stock Solutions for ML 418

The following data is based on the product molecular weight 377.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.23 mL 66.16 mL 132.32 mL
1 mM 2.65 mL 13.23 mL 26.46 mL
2 mM 1.32 mL 6.62 mL 13.23 mL
10 mM 0.26 mL 1.32 mL 2.65 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for ML 418

References are publications that support the biological activity of the product.

Swale et al (2016) ML418: the first selective, sub-micromolar pore blocker of Kir7.1 potassium channels. ACS Chem.Neurosci. 7 1013 PMID: 27184474

Kharade (2017) Pore polarity and charge determine differential block of Kir1.1 and Kir7.1 potassium channels by small-molecule inhibitor VU590. Mol.Pharmacol. 92 338 PMID: 28619748

If you know of a relevant reference for ML 418, please let us know.

View Related Products by Product Action

View all Inward Rectifier Potassium (Kir) Channel Blockers

Keywords: ML 418, ML 418 supplier, ML418, inward-rectifier, potassium, channels, Kir, 7.1, 6.2, inhibitors, inhibits, active, in, vivo, Inward, rectifier, Potassium, Channels, 6889, Tocris Bioscience

Citations for ML 418

Citations are publications that use Tocris products.

Currently there are no citations for ML 418. Do you know of a great paper that uses ML 418 from Tocris? Please let us know.

Reviews for ML 418

There are currently no reviews for this product. Be the first to review ML 418 and earn rewards!

Have you used ML 418?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Ion Channel Product Listing

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels
Pain Research Product Guide

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling