ML 418

Pricing Availability   Qty
Description: Kir 7.1 inhibitor; also inhibits Kir 6.2
Chemical Name: Isopropyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl)piperidin-4-yl)carbamate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for ML 418

ML 418 is a Kir7.1 inhibitor (IC50 = 0.31 μM). Also inhibits Kir6.2 with similar potency. Displays >17-fold selectivity for Kir7.1 over Kir1.1, Kir2.1, Kir2.2, Kir2.3, Kir3.1/3.2 and Kir4.1. Active in vivo.

Compound Libraries for ML 418

ML 418 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 418

M. Wt 377.87
Formula C19H24CIN3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1928763-08-9
PubChem ID 91667465
InChI Key CWIXCQOSULUGBT-UHFFFAOYSA-N
Smiles CC(OC(NC1CCN(CC1)CC2=C(C3=C(C(Cl)=C2)C=CC=N3)O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 418

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.56 20

Preparing Stock Solutions for ML 418

The following data is based on the product molecular weight 377.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.23 mL 66.16 mL 132.32 mL
1 mM 2.65 mL 13.23 mL 26.46 mL
2 mM 1.32 mL 6.62 mL 13.23 mL
10 mM 0.26 mL 1.32 mL 2.65 mL

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References for ML 418

References are publications that support the biological activity of the product.

Swale et al (2016) ML418: the first selective, sub-micromolar pore blocker of Kir7.1 potassium channels. ACS Chem.Neurosci. 7 1013 PMID: 27184474

Kharade (2017) Pore polarity and charge determine differential block of Kir1.1 and Kir7.1 potassium channels by small-molecule inhibitor VU590. Mol.Pharmacol. 92 338 PMID: 28619748


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Citations for ML 418

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