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Antimalarial. Prevents cerebral malaria in Plasmodium berghei infected mice. Exhibits synergistic effects with Methylene Blue (Cat. No. 3213) against P. falciparum in vitro. Inhibits neuroinflammation in neuronal/microglial cell co-cultures via induction of Nrf2 expression.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 298.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.35 mL||16.76 mL||33.52 mL|
|5 mM||0.67 mL||3.35 mL||6.7 mL|
|10 mM||0.34 mL||1.68 mL||3.35 mL|
|50 mM||0.07 mL||0.34 mL||0.67 mL|
References are publications that support the biological activity of the product.
Okorji et al (2015) Antimalarial drug artem. inhibits neuroinflammation in BV2 microglia through Nrf2-dependent mechanisms. Mol.Neurobiol. 53 PMID: 26607631
Prada et al (1996) Upregulation of reactive oxygen and nitrogen intermediates in Plasmodium berghei infected mice after rescue therapy with chloroquine or artem. J.Antimicrob.Chemother. 38 95 PMID: 8858461
Akoachere et al (2005) In vitro assessment of methylene blue on chloroquine-sensitive and -resistant Plasmodium falciparum strains reveals synergistic action with artemisinins. Antimicrob.Agents Chemother. 49 4592 PMID: 16251300
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Keywords: Artemether, Artemether supplier, antimalarials, malaria, plasmodium, neuroinflammation, inhibits, inhibitors, Antimalarials, 6818, Tocris Bioscience
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