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RS 246204

Cat. No. 8853 Submit a Review Datasheet / COA / SDS
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Description: R-Spondin-1 substitute used to initiate small intestinal organoids
Chemical Name: 3,7-Dihydro-3,7-dimethyl-8-(2-quinolinylthio)-1H-purine-2,6-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (5)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for RS 246204

RS 246204 is a R-Spondin-1 substitute. Able to initiate formation and growth of mouse intestinal organoids in media without R-Spondin-1 protein. In vivo, RS 24620 has regenerative effect in damaged intestinal epithelium mouse model.

Technical Data for RS 246204

M. Wt 339.37
Formula C16H13N5O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 878451-87-7
PubChem ID 6485821
InChI Key UHUHSGFUUWVRBO-UHFFFAOYSA-N
Smiles O=C1NC(N(C)C2=C1N(C)C(SC3=CC=C4C=CC=CC4=N3)=N2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RS 246204

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.7 5

Preparing Stock Solutions for RS 246204

The following data is based on the product molecular weight 339.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 58.93 mL 294.66 mL 589.33 mL
0.25 mM 11.79 mL 58.93 mL 117.87 mL
0.5 mM 5.89 mL 29.47 mL 58.93 mL
2.5 mM 1.18 mL 5.89 mL 11.79 mL

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References for RS 246204

References are publications that support the biological activity of the product.

Nam et al (2017) Effects of a small molecule R-spondin-1 substitute RS-246204 on a mouse intestinal organoid culture. Oncotarget 9 6356 PMID: 29464078

If you know of a relevant reference for RS 246204, please let us know.

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Keywords: RS 246204, RS 246204 supplier, RS246204, Organoid, R-spondin1, small, intestine, enteroid, 3D, culture, stem, cells, in, vivo, Organoids, 8853, Tocris Bioscience

Citations for RS 246204

Citations are publications that use Tocris products.

Currently there are no citations for RS 246204. Do you know of a great paper that uses RS 246204 from Tocris? Please let us know.

Reviews for RS 246204

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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