Targeted Protein DegradationUpdated

Custom Degrader Services

Tocris offers a custom service for the design and synthesis of degrader (PROTAC) building blocks for your targeted protein degradation research. Additionally, we can partner with your discovery project for the custom design and synthesis of active degraders.

Please complete our custom degrader services form to let us know your custom degrader requirements

Active Degraders - Tools for Targeted Protein Degradation

Figure 1: Schematic showing the catalytic mode of action of heterobifunctional degrader molecules. Degraders initiate the formation of a ternary complex between an E3 ubiquitin ligase and a target protein which results in polyubiquitination of the target protein, its recognition by the proteasome and subsequent degradation. Degraders act catalytically by repeatedly engaging and directing the ubiquitination of target molecules.

Adapted from Tinworth et al. (2016) Med.Chem.Comm. 7 2206.

Our sister Bio-Techne brands offer a range of E3 ligase enzymes, custom E3 ligase enzyme production, as well as assays and kits for ubiquitin research and proteomic analysis of ubiquitination.

Are you developing Degraders in your lab? For quantitative, reproducible and automated analysis of protein degradation, check out the Simple Western™ range from our sister brand, Protein Simple.