Pricing Availability   Qty
Description: Positive allosteric modulator of CB2 receptors; active in vivo
Chemical Name: N-[5-Bromo-1-[(4-fluorophenyl)methyl]-1,2-dihydro-4-methyl-2-oxo-3-pyridinyl]cycloheptanecarboxamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for Ec2la

Ec2la is a CB2 receptor positive allosteric modulator. Enhances CP 55940 (Cat. No. 0949) and 2-Arachidonylglycerol (Cat. No. 1298)-stimulated binding of [35S]GTPγS to CB2 receptors, but has no effect in the absence of agonist. Exhibits antinociceptive effects in an animal model of neuropathic pain.

Compound Libraries for Ec2la

Ec2la is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Ec2la

M. Wt 435.33
Formula C21H24BrFN2O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2244579-87-9
PubChem ID 137553165
Smiles CC1=C(C(N(C=C1Br)CC2=CC=C(C=C2)F)=O)NC(C3CCCCCC3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ec2la

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 8.71 20

Preparing Stock Solutions for Ec2la

The following data is based on the product molecular weight 435.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.49 mL 57.43 mL 114.86 mL
1 mM 2.3 mL 11.49 mL 22.97 mL
2 mM 1.15 mL 5.74 mL 11.49 mL
10 mM 0.23 mL 1.15 mL 2.3 mL

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References for Ec2la

References are publications that support the biological activity of the product.

Gado et al (2019) Identification of the first synthetic allosteric modulator of the CB2 receptors and evidence of its efficacy for neuropathic pain relief. J.Med.Chem. 62 276 PMID: 29990428

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Keywords: Ec2la, Ec2la supplier, CB2, positive, allosteric, modulator, PAM, cannabinoid, neuropathic, pain, Ec21a, Ec2Ia, Receptors, 6832, Tocris Bioscience

Citations for Ec2la

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.