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Cat.No. 6834 - Auxin | C10H9NO2 | CAS No. 87-51-4
Description: Chemical dimerizer used in auxin-inducible degron (AID) system; phytohormone
Chemical Name: 1H-Indole-3-acetic acid
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

Chemical dimerizer used in auxin-inducible degron (AID) systems. Induces degradation of a target protein tagged with the auxin-receptor F-box protein Tir1 E3 ligase AID in human colorectral cancer and mouse ES cells or tagged with AFB2 in A431 cells. Endogenous plant hormone.

Technical Data

M. Wt 175.18
Formula C10H9NO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 87-51-4
PubChem ID 802
Smiles OC(CC1=CNC2=C1C=CC=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 17.52 100
ethanol 17.52 100

Preparing Stock Solutions

The following data is based on the product molecular weight 175.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.71 mL 28.54 mL 57.08 mL
5 mM 1.14 mL 5.71 mL 11.42 mL
10 mM 0.57 mL 2.85 mL 5.71 mL
50 mM 0.11 mL 0.57 mL 1.14 mL

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References are publications that support the biological activity of the product.

Nishimura et al (2009) An auxin-based degron system for the rapid depletion of proteins in nonplant cells. Nat.Methods 6 917 PMID: 19915560

Natsume et al (2016) Rapid protein depletion in human cells by auxin-inducible degron tagging with short homology donors. Cell Rep. 15 210 PMID: 27052166

Li et al (2019) An efficient auxin-inducible degron system with low basal degradation in human cells. Nat.Methods. 16 866 PMID: 31451765

If you know of a relevant reference for Auxin, please let us know.

Keywords: Auxin, Auxin supplier, Auxin-inducible, degron, AID, targeted, protein, degradation, TPD, chemical, dimerizer, TIR1, phytohormone, Protein, Dimerizers, Biochemicals, and, Molecular, Biology, Glues, 6834, Tocris Bioscience

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