GSK 2795039

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Cat.No. 6848 - GSK 2795039 | C23H26N6O2S | CAS No. 1415925-18-6
Description: NADPH oxidase 2 (NOX2) inhibitor
Chemical Name: N-[3-(2,3-Dihydro-1-methyl-1H-indol-6-yl)-1-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl-1H-pyrazole-3-sulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for GSK 2795039

GSK 2795039 is a NADPH oxidase 2 (NOX2) inhibitor (pIC50 value is 5.5 to 6.5, depending on assay performed), which displays selectivity for NOX2 other NOX isoforms, xanthine oxidase and eNOS. GSK 2795039 inhibits reactive oxygen species (ROS) in cellular assays, and displays efficacy in rodent models of paw inflammation and acute pancreatitis.

Technical Data for GSK 2795039

M. Wt 450.56
Formula C23H26N6O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1415925-18-6
PubChem ID 71090129
InChI Key FMWVTCZKCXPKFW-UHFFFAOYSA-N
Smiles CC(N1C=C(C2=CC=C3CCN(C3=C2)C)C4=C(C=CN=C14)NS(=O)(C5=NN(C=C5)C)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GSK 2795039

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.06 100

Preparing Stock Solutions for GSK 2795039

The following data is based on the product molecular weight 450.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.1 mL 22.19 mL
5 mM 0.44 mL 2.22 mL 4.44 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References for GSK 2795039

References are publications that support the biological activity of the product.

Hirano et al (2015) Discovery of GSK2795039, a novel small molecule NADPH oxidase 2 inhibitor. Antioxid.Redox.Signal. 23 358 PMID: 26135714


If you know of a relevant reference for GSK 2795039, please let us know.

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Keywords: GSK 2795039, GSK 2795039 supplier, GSK2795039, NOX2, NADPH, oxidase, inhibitors, inhibits, reactive, oxygen, species, ROS, CYBB, cytochrome, b-245, beta, chain, Oxidase, 6848, Tocris Bioscience

Citations for GSK 2795039

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Currently there are no citations for GSK 2795039. Do you know of a great paper that uses GSK 2795039 from Tocris? Please let us know.

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