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Biological Activity for GSK 2795039
GSK 2795039 is a NADPH oxidase 2 (NOX2) inhibitor (pIC50 value is 5.5 to 6.5, depending on assay performed), which displays selectivity for NOX2 other NOX isoforms, xanthine oxidase and eNOS. GSK 2795039 inhibits reactive oxygen species (ROS) in cellular assays, and displays efficacy in rodent models of paw inflammation and acute pancreatitis.
Compound Libraries for GSK 2795039
Technical Data for GSK 2795039
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GSK 2795039
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for GSK 2795039
The following data is based on the product molecular weight 450.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.22 mL||11.1 mL||22.19 mL|
|5 mM||0.44 mL||2.22 mL||4.44 mL|
|10 mM||0.22 mL||1.11 mL||2.22 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
References for GSK 2795039
References are publications that support the biological activity of the product.
Hirano et al (2015) Discovery of GSK2795039, a novel small molecule NADPH oxidase 2 inhibitor. Antioxid.Redox.Signal. 23 358 PMID: 26135714
If you know of a relevant reference for GSK 2795039, please let us know.
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Keywords: GSK 2795039, GSK 2795039 supplier, GSK2795039, NOX2, NADPH, oxidase, inhibitors, inhibits, reactive, oxygen, species, ROS, CYBB, cytochrome, b-245, beta, chain, Oxidase, 6848, Tocris Bioscience
Citations for GSK 2795039
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Literature in this Area
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