GSK 2795039

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: NADPH oxidase 2 (NOX2) inhibitor
Chemical Name: N-[3-(2,3-Dihydro-1-methyl-1H-indol-6-yl)-1-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl-1H-pyrazole-3-sulfonamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for GSK 2795039

GSK 2795039 is a NADPH oxidase 2 (NOX2) inhibitor (pIC50 value is 5.5 to 6.5, depending on assay performed), which displays selectivity for NOX2 other NOX isoforms, xanthine oxidase and eNOS. GSK 2795039 inhibits reactive oxygen species (ROS) in cellular assays, and displays efficacy in rodent models of paw inflammation and acute pancreatitis.

Compound Libraries for GSK 2795039

GSK 2795039 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GSK 2795039

M. Wt 450.56
Formula C23H26N6O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1415925-18-6
PubChem ID 71090129
Smiles CC(N1C=C(C2=CC=C3CCN(C3=C2)C)C4=C(C=CN=C14)NS(=O)(C5=NN(C=C5)C)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GSK 2795039

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 45.06 100

Preparing Stock Solutions for GSK 2795039

The following data is based on the product molecular weight 450.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.1 mL 22.19 mL
5 mM 0.44 mL 2.22 mL 4.44 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for GSK 2795039

References are publications that support the biological activity of the product.

Hirano et al (2015) Discovery of GSK2795039, a novel small molecule NADPH oxidase 2 inhibitor. Antioxid.Redox.Signal. 23 358 PMID: 26135714

If you know of a relevant reference for GSK 2795039, please let us know.

View Related Products by Target

View Related Products by Product Action

View all NADPH Oxidase Inhibitors

Keywords: GSK 2795039, GSK 2795039 supplier, GSK2795039, NOX2, NADPH, oxidase, inhibitors, inhibits, reactive, oxygen, species, ROS, CYBB, cytochrome, b-245, beta, chain, Oxidase, 6848, Tocris Bioscience

Citations for GSK 2795039

Citations are publications that use Tocris products.

Currently there are no citations for GSK 2795039. Do you know of a great paper that uses GSK 2795039 from Tocris? Please let us know.

Reviews for GSK 2795039

There are currently no reviews for this product. Be the first to review GSK 2795039 and earn rewards!

Have you used GSK 2795039?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.