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Zeta-chain-associated protein kinase 70 (Zap70) inhibitor (IC50 = 1.8 μM in fluorescence polarization assay). Inhibits the interaction of Zap70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs), within the T-cell antigen receptor (TCR) signaling pathway.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 454.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.2 mL||11.01 mL||22.01 mL|
|5 mM||0.44 mL||2.2 mL||4.4 mL|
|10 mM||0.22 mL||1.1 mL||2.2 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
References are publications that support the biological activity of the product.
Visperas et al (2017) Identification of inhibitors of the association of ZAP-70 with the T-cell receptor by high-throughput screen. SLAS.Discov. 22 324 PMID: 27932698
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