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Biological Activity for BMS 466442
BMS 466442 is a potent and selective asc-1 (alanine-serine-cysteine-1) transporter inhibitor (IC50 values are 20 and 37 nM in rat primary cortical cultures and HEK cells expressing asc-1 respectively). Displays >1000-fold selectivity for asc-1 over LAT-2 and ASCT-2. This compound is unsuitable for in vivo studies.
Technical Data for BMS 466442
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BMS 466442
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for BMS 466442
The following data is based on the product molecular weight 538.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.86 mL||9.28 mL||18.57 mL|
|5 mM||0.37 mL||1.86 mL||3.71 mL|
|10 mM||0.19 mL||0.93 mL||1.86 mL|
|50 mM||0.04 mL||0.19 mL||0.37 mL|
References for BMS 466442
References are publications that support the biological activity of the product.
Torrecillas et al (2019) Inhibition of the alanine-serine-cysteine-1 transporter by BMS-466442. ACS Chem.Neurosci. 10 2510 PMID: 30821959
Brown et al (2014) In vitro characterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10). J.Neurochem. 129 275 PMID: 24266811
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Citations for BMS 466442
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