BMS 466442

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Cat.No. 6878 - BMS 466442 | C31H30N4O5 | CAS No. 1598424-76-0
Description: Potent and selective inhibitor of asc-1
Chemical Name: N-[[5-Methoxy-6-(phenylmethoxy)-1H-indol-2-yl]carbonyl]-1-(phenylmethyl)-L-histidine methyl ester
Purity: ≥98% (HPLC)
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Biological Activity for BMS 466442

BMS 466442 is a potent and selective asc-1 (alanine-serine-cysteine-1) transporter inhibitor (IC50 values are 20 and 37 nM in rat primary cortical cultures and HEK cells expressing asc-1 respectively). Displays >1000-fold selectivity for asc-1 over LAT-2 and ASCT-2. This compound is unsuitable for in vivo studies.

Technical Data for BMS 466442

M. Wt 538.6
Formula C31H30N4O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1598424-76-0
PubChem ID 124082063
InChI Key UUCAHZCMRZOTNF-MHZLTWQESA-N
Smiles COC(=O)[C@H](CC1=CN(CC2=CC=CC=C2)C=N1)NC(=O)C1=CC2=CC(OC)=C(OCC3=CC=CC=C3)C=C2N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BMS 466442

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.86 100

Preparing Stock Solutions for BMS 466442

The following data is based on the product molecular weight 538.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.86 mL 9.28 mL 18.57 mL
5 mM 0.37 mL 1.86 mL 3.71 mL
10 mM 0.19 mL 0.93 mL 1.86 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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References for BMS 466442

References are publications that support the biological activity of the product.

Torrecillas et al (2019) Inhibition of the alanine-serine-cysteine-1 transporter by BMS-466442. ACS Chem.Neurosci. 10 2510 PMID: 30821959

Brown et al (2014) In vitro characterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10). J.Neurochem. 129 275 PMID: 24266811


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Citations for BMS 466442

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