uPSEM 792 hydrochloride

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Description: Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant
Chemical Name: 1-Methyl-7,8,9,10-tetrahydro-1H-6,10-methanoazepino[4,5-g]quinoxalin-2(6H)-one hydrochloride
Purity: ≥98% (HPLC)
Citations (3)
Literature (1)

Biological Activity for uPSEM 792 hydrochloride

uPSEM 792 hydrochloride is a ultrapotent PSEM (uPSEM) agonist for PSAM4-GlyR and PSAM4-5HT3 (Ki = 0.7 nM for PSAM4-GlyR and <10 nM for PSAM4-5HT3). Exhibits >10,000-fold agonist selectivity for PSAM4-GlyR over α7-GlyR, α7-5HT3, and 5HT3-R, and 230-fold selectivity over α4β2 nAChR. Also weak partial agonist (~10 %) at α4β2 nAChR. Retains the potency of varenicline (Cat.No. 3754) for PSAM4-GlyR with enhanced chemogenetic selectivity. Does not act as a substrate for P-glycoprotein pumps. Silences neurons in vivo. Brain-penetrant.

Licensing Information

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
For scientific research use only. This product may not be used to research, develop, make, use, offer to sell, sell, or import any products for human therapeutic uses.

Technical Data for uPSEM 792 hydrochloride

M. Wt 277.75
Formula C14H15N3O.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2341841-08-3
Smiles O=C1C=NC2=C(C=C3C(C4CNCC3C4)=C2)N1C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for uPSEM 792 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 27.77 100

Preparing Stock Solutions for uPSEM 792 hydrochloride

The following data is based on the product molecular weight 277.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.6 mL 18 mL 36 mL
5 mM 0.72 mL 3.6 mL 7.2 mL
10 mM 0.36 mL 1.8 mL 3.6 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets for uPSEM 792 hydrochloride

Certificate of Analysis / Product Datasheet
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References for uPSEM 792 hydrochloride

References are publications that support the biological activity of the product.

Magnus et al (2019) Ultrapotent chemogenetics for research and potential clinical applications. Science doi: 10.1126/science PMID: 30872534

If you know of a relevant reference for uPSEM 792 hydrochloride, please let us know.

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3 Citations for uPSEM 792 hydrochloride

Citations are publications that use Tocris products. Selected citations for uPSEM 792 hydrochloride include:

Manuel et al (2022) Extrinsic control and intrinsic computation in the hippocampal CA1 circuit. Neuron 110 658-673.e5 PMID: 34890566

Ji-Hye et al (2023) Neocortical synaptic engrams for remote contextual memories. Nat Neurosci 26 259-273 PMID: 36564546

Perez-Sanchez et al (2023) A humanized chemogenetic system inhibits murine pain-related behavior and hyperactivity in human sensory neurons Sci.Transl.Med 15 eadh3839 PMID: 37792955

Do you know of a great paper that uses uPSEM 792 hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Chemogenetics Research Bulletin

Chemogenetics Research Bulletin

Produced by Tocris, the chemogenetics research bulletin provides an introduction to chemogenetic methods to manipulate neuronal activity. It outlines the development of RASSLs, DREADDs and PSAMs, and the use of chemogenetic compounds. DREADD ligands and PSEMs available from Tocris are highlighted.