uPSEM 792 hydrochloride

Pricing Availability   Qty
Cat.No. 6865 - uPSEM 792 hydrochloride | C14H15N3O.HCl
Description: Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant
Chemical Name: 1-Methyl-7,8,9,10-tetrahydro-1H-6,10-methanoazepino[4,5-g]quinoxalin-2(6H)-one hydrochloride
Purity: ≥96% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Ultrapotent PSEM (uPSEM) agonist for PSAM4-GlyR and PSAM4-5HT3 (Ki = 0.7 nM for PSAM4-GlyR and <10 nM for PSAM4-5HT3). Exhibits >10,000-fold agonist selectivity for PSAM4-GlyR over α7-GlyR, α7-5HT3, and 5HT3-R, and 230-fold selectivity over α4β2 nAChR. Also weak partial agonist (~10 %) at α4β2 nAChR. Retains the potency of varenicline (Cat.No. 3754) for PSAM4-GlyR with enhanced chemogenetic selectivity. Does not act as a substrate for P-glycoprotein pumps. Silences neurons in vivo. Brain-penetrant.

Licensing Information

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
For scientific research use only. This product may not be used to research, develop, make, use, offer to sell, sell, or import any products for human therapeutic uses.

Technical Data

M. Wt 277.75
Formula C14H15N3O.HCl
Storage Store at -20°C
Purity ≥96% (HPLC)
Smiles O=C1C=NC2=C(C=C3C(C4CNCC3C4)=C2)N1C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 27.77 100

Preparing Stock Solutions

The following data is based on the product molecular weight 277.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.6 mL 18 mL 36 mL
5 mM 0.72 mL 3.6 mL 7.2 mL
10 mM 0.36 mL 1.8 mL 3.6 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Magnus et al (2019) Ultrapotent chemogenetics for research and potential clinical applications. Science doi: 10.1126/science PMID: 30872534


If you know of a relevant reference for uPSEM 792 hydrochloride, please let us know.

Keywords: uPSEM 792 hydrochloride, uPSEM 792 hydrochloride supplier, uPSEM792, hydrochloride, ultrapotent, PSEM, uPSEM, agonists, agonsim, PSAM4-GlyR, PSAM4-5HT3, selective, brain, penetrant, PSEMs, Nicotinic, (a4b2), Receptors, 6865, Tocris Bioscience

Citations for uPSEM 792 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for uPSEM 792 hydrochloride. Do you know of a great paper that uses uPSEM 792 hydrochloride from Tocris? Please let us know.

Reviews for uPSEM 792 hydrochloride

There are currently no reviews for this product. Be the first to review uPSEM 792 hydrochloride and earn rewards!

Have you used uPSEM 792 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Ion Channel

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels
Chemogenetics

Chemogenetics Research Bulletin

Produced by Tocris, the chemogenetics research bulletin provides an introduction to chemogenetic methods to manipulate neuronal activity. It outlines the development of RASSLs, DREADDs and PSAMs, and the use of chemogenetic compounds. DREADD ligands and PSEMs available from Tocris are highlighted.