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TRPV3 74a

Cat. No. 6831 Submit a Review Datasheet / COA / SDS
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Description: Selective TRPV3 antagonist; brain penetrant
Chemical Name: (αS)-α-[cis-3-Hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-2-pyridinemethanol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for TRPV3 74a

TRPV3 74a is a selective TRPV3 antagonist (KB = 0.56 μM). Displays no significant activity against a panel of other ion channels. Exhibits efficacy in animal models of neuropathic pain. Brain penetrant.

Technical Data for TRPV3 74a

M. Wt 338.32
Formula C17H17F3N2O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1432051-63-2
PubChem ID 71554840
InChI Key MTJXDHFAWXGXIN-OAGGEKHMSA-N
Smiles C[C@]1(C[C@@]([C@@H](C2=CC=CC=N2)O)(C3=CC(C(F)(F)F)=CC=N3)C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TRPV3 74a

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.83 100

Preparing Stock Solutions for TRPV3 74a

The following data is based on the product molecular weight 338.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.78 mL 29.56 mL
5 mM 0.59 mL 2.96 mL 5.91 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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References for TRPV3 74a

References are publications that support the biological activity of the product.

Gomtsyan et al (2016) Synthesis and pharmacology of (pyridin-2-yl)methanol derivatives as novel and selective transient receptor potential vanilloid 3 antagonists. J.Med.Chem. 59 4926 PMID: 27077528

If you know of a relevant reference for TRPV3 74a, please let us know.

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Citations for TRPV3 74a

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Literature in this Area

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Pain Research Product Guide

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Pain Poster

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.