TRPV3 74a

Pricing Availability   Qty
Description: Selective TRPV3 antagonist; brain penetrant
Chemical Name:S)-α-[cis-3-Hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-2-pyridinemethanol
Purity: ≥98% (HPLC)

Biological Activity for TRPV3 74a

TRPV3 74a is a selective TRPV3 antagonist (KB = 0.56 μM). Displays no significant activity against a panel of other ion channels. Exhibits efficacy in animal models of neuropathic pain. Brain penetrant.

Technical Data for TRPV3 74a

M. Wt 338.32
Formula C17H17F3N2O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1432051-63-2
PubChem ID 71554840
Smiles C[C@]1(C[C@@]([C@@H](C2=CC=CC=N2)O)(C3=CC(C(F)(F)F)=CC=N3)C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TRPV3 74a

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.83 100

Preparing Stock Solutions for TRPV3 74a

The following data is based on the product molecular weight 338.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.78 mL 29.56 mL
5 mM 0.59 mL 2.96 mL 5.91 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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References for TRPV3 74a

References are publications that support the biological activity of the product.

Gomtsyan et al (2016) Synthesis and pharmacology of (pyridin-2-yl)methanol derivatives as novel and selective transient receptor potential vanilloid 3 antagonists. J.Med.Chem. 59 4926 PMID: 27077528

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