You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
uPSEM 817 tartrate
Biological Activity for uPSEM 817 tartrate
uPSEM 817 tartrate is a selective ultrapotent PSEM (uPSEM) agonist for α7L131G,Q139L,Y217F-GlyR (PSAM4-GlyR) and PSAM4-5-HT3 chimeric ion channels (EC50 values are 0.3 and 0.5 nM, respectively). Suppresses firing of layer 2/3 cortical neurons expressing PSAM4-GlyR in brain slices. Increases contralateral rotation in mice expressing PSAM4-GlyR unilaterally in the substantia nigra reticulata (LED 0.1 mg/kg).
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
For scientific research use only. This product may not be used to research, develop, make, use, offer to sell, sell, or import any products for human therapeutic uses.
Technical Data for uPSEM 817 tartrate
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for uPSEM 817 tartrate
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for uPSEM 817 tartrate
The following data is based on the product molecular weight 419.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.38 mL||11.92 mL||23.84 mL|
|5 mM||0.48 mL||2.38 mL||4.77 mL|
|10 mM||0.24 mL||1.19 mL||2.38 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
Product Datasheets for uPSEM 817 tartrate
References for uPSEM 817 tartrate
References are publications that support the biological activity of the product.
Magnus et al (2019) Ultrapotent chemogenetics for research and potential clinical applications. Science 364 PMID: 30872534
If you know of a relevant reference for uPSEM 817 tartrate, please let us know.
Keywords: uPSEM 817 tartrate, uPSEM 817 tartrate supplier, uPSEM817, tartrate, highly, potent, selective, α, alpha7L131G,Q139L,Y217F-GlyR, PSAM4-GlyR, agonists, agonism, PSEM, chemogenetics, PSEMs, Glycine, Receptors, 5-HT3, 6866, Tocris Bioscience
Citations for uPSEM 817 tartrate
Citations are publications that use Tocris products.
Currently there are no citations for uPSEM 817 tartrate. Do you know of a great paper that uses uPSEM 817 tartrate from Tocris? Please let us know.
Reviews for uPSEM 817 tartrate
There are currently no reviews for this product. Be the first to review uPSEM 817 tartrate and earn rewards!
Have you used uPSEM 817 tartrate?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Chemogenetics Research Bulletin
Produced by Tocris, the chemogenetics research bulletin provides an introduction to chemogenetic methods to manipulate neuronal activity. It outlines the development of RASSLs, DREADDs and PSAMs, and the use of chemogenetic compounds. DREADD ligands and PSEMs available from Tocris are highlighted.