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ML 67-33

Cat. No. 6886 1 Citation Submit a Review Datasheet / COA / SDS

Discontinued Product

6886 has been discontinued.

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Description: K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) channel activator
Chemical Name: 2,7-Dichloro-9,10-dihydro-9,9-dimethyl-10-[2-(2H-tetrazol-5-yl)ethyl]acridine
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Datasheets References

Biological Activity for ML 67-33

ML 67-33 is a K2P potassium channel activator (EC50 values are 21.8 - 29.4 μM, 30.2 μM and 27.3 μM for K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) respectively, expressed in xenopus oocytes). Increases channel currents by activating core gating apparatus of channels. In a mouse migraine model, ML 67-33 improves pain symptoms via activation of TREK 1/2 currents in trigeminal ganglion sensory neurons.

Compound Libraries for ML 67-33

ML 67-33 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 67-33

M. Wt 374.27
Formula C18H17Cl2N5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1443290-89-8
PubChem ID 86272454
InChI Key GQPMJOXQJUGJPG-UHFFFAOYSA-N
Smiles CC1(C2=CC(Cl)=CC=C2N(C3=CC=C(C=C13)Cl)CCC4=NN=NN4)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for ML 67-33

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for ML 67-33

References are publications that support the biological activity of the product.

Bagriantsev et al (2013) A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels. ACS Chem.Biol. 8 1841 PMID: 23738709

Pope et al (2018) Protein and chemical determinants of BL-1249 action and selectivity for K2P channels. ACS Chem.Neurosci. 9 3153 PMID: 30089357

Prado et al (2021) TREK channel activation suppresses migraine pain phenotype. iScience 24 102961 PMID: 34458705

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1 Citation for ML 67-33

Citations are publications that use Tocris products. Selected citations for ML 67-33 include:

Prado et al (2021) TREK channel activation suppresses migraine pain phenotype. iScience 24 102961 PMID: 34458705

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