ML 67-33

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Cat.No. 6886 - ML 67-33 | C18H17Cl2N5 | CAS No. 1443290-89-8
Description: K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) channel activator
Chemical Name: 2,7-Dichloro-9,10-dihydro-9,9-dimethyl-10-[2-(2H-tetrazol-5-yl)ethyl]acridine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

K2P potassium channel activator (EC50 values are 21.8 - 29.4 μM, 30.2 μM and 27.3 μM for K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) respectively, expressed in xenopus oocytes). Increases channel currents by activating core gating apparatus of channels.

Technical Data

M. Wt 374.27
Formula C18H17Cl2N5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1443290-89-8
PubChem ID 86272454
InChI Key GQPMJOXQJUGJPG-UHFFFAOYSA-N
Smiles CC1(C2=CC(Cl)=CC=C2N(C3=CC=C(C=C13)Cl)CCC4=NN=NN4)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 374.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.67 mL 13.36 mL 26.72 mL
5 mM 0.53 mL 2.67 mL 5.34 mL
10 mM 0.27 mL 1.34 mL 2.67 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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References

References are publications that support the biological activity of the product.

Bagriantsev et al (2013) A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels. ACS Chem.Biol. 8 1841 PMID: 23738709

Pope et al (2018) Protein and chemical determinants of BL-1249 action and selectivity for K2P channels. ACS Chem.Neurosci. 9 3153 PMID: 30089357


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