DNA, RNA and Protein Synthesis Inhibitors

Cat. No. Product Name / Activity
4215 4E1RCat
Protein translation inhibitor; blocks eIF4F subunit interaction
4800 4EGI-1
Inhibitor of eIF4E:eIF4G interaction
1229 Actinomycin D
RNA polymerase inhibitor
2513 Acyclovir
Viral DNA polymerase inhibitor
4025 α-Amanitin
Inhibitor of RNA polymerase II
1290 Anisomycin
Protein synthesis inhibitor
5736 Aphidicolin
DNA polymerase α, δ and ε inhibitor
6392 B02
RAD51 recombinase inhibitor
2981 BIBR 1532
Selective telomerase inhibitor
5417 BMH 21
RNA polymerase 1 inhibitor; also p53 pathway activator
5312 BRACO 19 trihydrochloride
Telomerase inhibitor
6196 Brequinar sodium
Potent and selective DHODH inhibitor
4799 Capecitabine
Prodrug of 5-Fluorouracil (Cat. No. 3257). Inhibits DNA synthesis
2626 Carboplatin
Inhibitor of DNA synthesis
4436 8-Chloroadenosine
Cytotoxic nucleoside analog; inhibits RNA synthesis
2294 Cordycepin
RNA synthesis inhibitor
2483 Costunolide
Inhibitor of human telomerase activity
0970 Cycloheximide
Inhibitor of protein synthesis
4520 Cytarabine
Nucleoside analog; inhibits DNA replication
3917 Daptomycin
Antibiotic; inhibits protein, DNA and RNA synthesis in gram-positive bacteria
1467 Daunorubicin hydrochloride
RNA synthesis inhibitor
3857 Dexrazoxane hydrochloride
Topoisomerase II inhibitor
7342 Emetine dihydrochloride
RNA polymerase inhibitor; inhibits replication of a broad range of RNA and DNA viruses, including SARS-CoV-2 and Zika
3260 Epirubicin hydrochloride
Inhibits DNA synthesis and function. Inhibits DNA topoisomerase II
4659 Floxuridine
Disrupts DNA replication; inhibits thymidylate synthetase
3495 Fludarabine
Purine analog; inhibits DNA synthesis
3257 5-Fluorouracil
Inhibits RNA and DNA synthesis
4131 G418 disulfate salt
Aminoglycoside antibiotic; used in cell culture
3259 Gemcitabine hydrochloride
DNA synthesis inhibitor
1993 Halofuginone hydrobromide
High affinity competitive prolyl-tRNA synthetase inhibitor
1416 Homoharringtonine
Inhibitor of protein synthesis; antileukemic agent
5740 6-Hydroxy-DL-DOPA
Allosteric inhibitor of RAD52; also APE1 inhibitor
6483 Isoginkgetin
Pre-mRNA splicing inhibitor; cell permeable
7338 K 22
Inhibits coronavirus RNA replication; impairs double membrane vesicle (DMV) formation
6068 Lin28 1632
RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor
3765 Linezolid
Antibiotic; inhibits protein synthesis in gram-positive bacteria
6510 LNT 1
Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response
6819 Mefloquine hydrochloride
Binds 80S ribosome and inhibits protein synthesis in P falciparum; also gap junction blocker
4103 6-Mercaptopurine
Purine analog; inhibits DNA and RNA synthesis
1489 Mithramycin A
Inhibitor of DNA and RNA polymerase
3258 Mitomycin C
Inhibitor of DNA synthesis
6359 Nelarabine
Purine nuceloside analog; inhibits DNA synthesis
5340 NSC 617145
Werner syndrome helicase (WRN) inhibitor
2623 Oxaliplatin
Inhibitor of DNA synthesis
5419 PCNA I1
PCNA inhibitor
6222 PFM 01
MRE11 endonuclease inhibitor
6070 Pladienolide B
mRNA splicing inhibitor; antitumor
7321 Pritelivir
Potent and selective herpes simplex virus (HSV) helicase primase inhibitor
4089 Puromycin dihydrochloride
Protein synthesis inhibitor
6168 RI 1
RAD51 recombinase inhibitor
4501 Ribavirin
Antiviral guanosine analog; blocks eIF4E activity
4121 Rifampicin
Antibiotic; inhibits bacterial RNA polymerase
4723 T2AA
PCNA inhibitor
6884 TC SL C5
Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor
5069 Teriflunomide
Inhibitor of DHODH; active metabolite of Leflunomide
3267 Thiostrepton
Antibiotic, inhibits protein synthesis
4309 TPEN
RNA binding protein Lin28 inhibitor; cell-permeable Zn2+ chelator
3253 Triptolide
Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive
3863 Trovafloxacin mesylate
Antibiotic; inhibits bacterial DNA synthesis
3787 Viomycin
Antibiotic; inhibits bacterial DNA synthesis
4067 YK 4-279
Inhibitor of RNA helicase A (RHA)