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Biological Activity for Fludarabine
Fludarabine is a purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Inhibits cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in lymphocytes. Also displays anticancer activity against hematological malignancies in vivo.
Compound Libraries for Fludarabine
Technical Data for Fludarabine
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Fludarabine
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Fludarabine
The following data is based on the product molecular weight 285.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.51 mL||17.53 mL||35.06 mL|
|5 mM||0.7 mL||3.51 mL||7.01 mL|
|10 mM||0.35 mL||1.75 mL||3.51 mL|
|50 mM||0.07 mL||0.35 mL||0.7 mL|
References for Fludarabine
References are publications that support the biological activity of the product.
Bellosillo et al (1999) In vitro evaluation of fludar. in combination with cyclophosph. and/or mitoxan. in B-cell chronic lymphocytic leukemia. Blood 94 2836 PMID: 10515887
Meng et al (2007) Antitumor activity of fludar. against human multiple myeloma in vitro and in vivo. Eur.J.Haematol. 79 486 PMID: 17976186
Torella et al (2007) Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation. Am.J.Physiol.Heart Circ.Physiol. 292 H2935 PMID: 17293493
Frank et al (1999) Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling. Nat.Med. 5 444 PMID: 10202937
If you know of a relevant reference for Fludarabine, please let us know.
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10 Citations for Fludarabine
Citations are publications that use Tocris products. Selected citations for Fludarabine include:
Nathalie et al (2014) Fludarabine downregulates indoleamine 2,3-dioxygenase in tumors via a proteasome-mediated degradation mechanism. PLoS One 9 e99211 PMID: 24911872
Robinson et al (2013) RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLoS One 8 e78641 PMID: 24265703
Brij B et al (2021) Resolving macrophage polarization through distinct Ca2+ entry channel that maintains intracellular signaling and mitochondrial bioenergetics. iScience 24 103339 PMID: 34816101
Fred et al (2020) STAT Signaling Modifies Ascl1 Chromatin Binding and Limits Neural Regeneration from Muller Glia in Adult Mouse Retina. Cell Rep 30 2195-2208.e5 PMID: 32075759
Beate et al (2020) Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin. Cell Mol Immunol 17 380-394 PMID: 31324882
Haiyan et al (2019) E3-ubiquitin ligase TRIM6 aggravates myocardial ischemia/reperfusion injury via promoting STAT1-dependent cardiomyocyte apoptosis. Aging (Albany NY) 11 3536-3550 PMID: 31171760
Yuwei et al (2023) Age-dependent Pdgfrβ signaling drives adipocyte progenitor dysfunction to alter the beige adipogenic niche in male mice. Nat Commun 14 1806 PMID: 37002214
Alexey et al (2022) Attenuation of SARS-CoV-2 replication and associated inflammation by concomitant targeting of viral and host cap 2'-O-ribose methyltransferases. EMBO J 41 e111608 PMID: 35833542
Xiang et al (2022) A positive feedback loop between gastric cancer cells and tumor-associated macrophage induces malignancy progression. J Exp Clin Cancer Res 41 174 PMID: 35562774
Odendall et al (2014) Diverse intracellular pathogens activate type III IF. expression from peroxisomes. Nat Immunol 15 717 PMID: 24952503
Do you know of a great paper that uses Fludarabine from Tocris? Please let us know.
Reviews for Fludarabine
Average Rating: 5 (Based on 1 Review.)
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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