Fludarabine

Pricing Availability Delivery Time Qty
Cat.No. 3495 - Fludarabine | C10H12FN5O4 | CAS No. 21679-14-1
Description: Purine analog; inhibits DNA synthesis
Chemical Name: 9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Inhibits cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in lymphocytes. Also displays anticancer activity against hematological malignancies in vivo.

Compound Libraries

Fludarabine is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 285.23
Formula C10H12FN5O4
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 21679-14-1
PubChem ID 657237
InChI Key HBUBKKRHXORPQB-FJFJXFQQSA-N
Smiles O[C@@H]1[C@@H](CO)O[C@@H](N3C2=NC(F)=NC(N)=C2N=C3)[C@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.52 100

Preparing Stock Solutions

The following data is based on the product molecular weight 285.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.51 mL 17.53 mL 35.06 mL
5 mM 0.7 mL 3.51 mL 7.01 mL
10 mM 0.35 mL 1.75 mL 3.51 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Bellosillo et al (1999) In vitro evaluation of fludarabine in combination with cyclophosphamide and/or mitoxantrone in B-cell chronic lymphocytic leukemia. Blood 94 2836 PMID: 10515887

Meng et al (2007) Antitumor activity of fludarabine against human multiple myeloma in vitro and in vivo. Eur.J.Haematol. 79 486 PMID: 17976186

Torella et al (2007) Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation. Am.J.Physiol.Heart Circ.Physiol. 292 H2935 PMID: 17293493

Frank et al (1999) Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling. Nat.Med. 5 444 PMID: 10202937


If you know of a relevant reference for Fludarabine, please let us know.

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View all DNA, RNA and Protein Synthesis Inhibitors

Keywords: Purine analog inhibits inhibitors DNA synthesis Proapoptotic increases Bax decreases Bid XIAP survivin expression Apoptosis Inducer STAT1 chemotherapeutics DNA, RNA and Protein Synthesis

2 Citations for Fludarabine

Citations are publications that use Tocris products. Selected citations for Fludarabine include:

Odendall et al (2014) Diverse intracellular pathogens activate type III interferon expression from peroxisomes. Nat Immunol 15 717 PMID: 24952503

Robinson et al (2013) RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLoS One 8 e78641 PMID: 24265703


Do you know of a great paper that uses Fludarabine from Tocris? If so please let us know.

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for Fludarabine

Protocols

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