Pricing Availability   Qty
Description: Purine analog; inhibits DNA synthesis
Chemical Name: 9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine
Purity: ≥98% (HPLC)
Citations (10)
Reviews (1)
Literature (2)

Biological Activity for Fludarabine

Fludarabine is a purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Inhibits cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in lymphocytes. Also displays anticancer activity against hematological malignancies in vivo.

Compound Libraries for Fludarabine

Fludarabine is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Fludarabine

M. Wt 285.23
Formula C10H12FN5O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 21679-14-1
PubChem ID 657237
Smiles O[C@@H]1[C@@H](CO)O[C@@H](N3C2=NC(F)=NC(N)=C2N=C3)[C@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Fludarabine

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.52 100

Preparing Stock Solutions for Fludarabine

The following data is based on the product molecular weight 285.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.51 mL 17.53 mL 35.06 mL
5 mM 0.7 mL 3.51 mL 7.01 mL
10 mM 0.35 mL 1.75 mL 3.51 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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Product Datasheets for Fludarabine

Certificate of Analysis / Product Datasheet
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References for Fludarabine

References are publications that support the biological activity of the product.

Bellosillo et al (1999) In vitro evaluation of fludar. in combination with cyclophosph. and/or mitoxan. in B-cell chronic lymphocytic leukemia. Blood 94 2836 PMID: 10515887

Meng et al (2007) Antitumor activity of fludar. against human multiple myeloma in vitro and in vivo. Eur.J.Haematol. 79 486 PMID: 17976186

Torella et al (2007) Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation. Am.J.Physiol.Heart Circ.Physiol. 292 H2935 PMID: 17293493

Frank et al (1999) Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling. Nat.Med. 5 444 PMID: 10202937

If you know of a relevant reference for Fludarabine, please let us know.

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View all DNA, RNA and Protein Synthesis Inhibitors

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10 Citations for Fludarabine

Citations are publications that use Tocris products. Selected citations for Fludarabine include:

Yuwei et al (2023) Age-dependent Pdgfrβ signaling drives adipocyte progenitor dysfunction to alter the beige adipogenic niche in male mice. Nat Commun 14 1806 PMID: 37002214

Robinson et al (2013) RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLoS One 8 e78641 PMID: 24265703

Nathalie et al (2014) Fludarabine downregulates indoleamine 2,3-dioxygenase in tumors via a proteasome-mediated degradation mechanism. PLoS One 9 e99211 PMID: 24911872

Brij B et al (2021) Resolving macrophage polarization through distinct Ca2+ entry channel that maintains intracellular signaling and mitochondrial bioenergetics. iScience 24 103339 PMID: 34816101

Do you know of a great paper that uses Fludarabine from Tocris? Please let us know.

Reviews for Fludarabine

Average Rating: 5 (Based on 1 Review.)

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STAT1 inhibitor in IFN beta signaling.
By Richa Rani on 01/04/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Hepatic stellate cells and hepatocytes

I used it to check its effect on drug stimulated hepatic stellate cell and its signaling.

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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