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Description: Blocks eIF4E activity; antiviral guanosine analog
Chemical Name: 1-β-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
Purity: ≥99% (HPLC)

Biological Activity for Ribavirin

Ribavirin is an antiviral guanosine ribonucleoside analog; misincorporated into mRNA by viral-dependent RNA polymerases. Binds to and redistributes mammalian eIF4E from the nucleus to the cytoplasm (Ki ~ 0.3 μM for the active metabolite, ribavirin triphosphate). Also inosine monophosphate dehydrogenase (IMPDH) inhibitor. Represses colony formation of primary AML-M5 progenitor cells (IC50 ~ 1 μM); reduces disease severity in acute myeloid leukemia (AML). Inhibits cytopathic effect of SARS-CoV in Vero cells in vitro. Orally available.

Compound Libraries for Ribavirin

Ribavirin is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Ribavirin

M. Wt 244.2
Formula C8H12N4O5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 36791-04-5
PubChem ID 37542
Smiles O[C@@H]1[C@@H](CO)O[C@@H](N2C=NC(C(N)=O)=N2)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ribavirin

Solvent Max Conc. mg/mL Max Conc. mM
water 24.42 100
DMSO 24.42 100

Preparing Stock Solutions for Ribavirin

The following data is based on the product molecular weight 244.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.1 mL 20.48 mL 40.95 mL
5 mM 0.82 mL 4.1 mL 8.19 mL
10 mM 0.41 mL 2.05 mL 4.1 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

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Product Datasheets for Ribavirin

Certificate of Analysis / Product Datasheet
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References for Ribavirin

References are publications that support the biological activity of the product.

Kentsis et al (2004) Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap. Proc.Natl.Acad.Sci.U.S.A. 101 18105 PMID: 15601771

Assouline et al (2009) Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with riba. Blood 114 257 PMID: 19433856

Tan et al (2004) Inhibition of SARS coronavirus infection in vitro with clinically approved antiviral drugs. Emerg.Infect.Dis. 10 581 PMID: 15200845

Graci and Cameron (2006) Mechanisms of action of ribavirin against distinct viruses. Rev.Med.Virol. 16 37 PMID: 16287208

If you know of a relevant reference for Ribavirin, please let us know.

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⚠ WARNING: This product can expose you to chemicals including Ribavirin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Ribavirin

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