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Biological Activity for Cordycepin
Cordycepin is a nucleoside analog that acts as an anticancer and antifungal agent. Can be converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA synthesis. Inhibits growth of various tumor cells in vitro.
Technical Data for Cordycepin
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Cordycepin
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Cordycepin
The following data is based on the product molecular weight 251.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.98 mL||19.9 mL||39.8 mL|
|5 mM||0.8 mL||3.98 mL||7.96 mL|
|10 mM||0.4 mL||1.99 mL||3.98 mL|
|50 mM||0.08 mL||0.4 mL||0.8 mL|
References for Cordycepin
References are publications that support the biological activity of the product.
Gumport and Edelhei et al (1976) The synthesis of 3'-dATP and its use as an inhibitor of ATP-dependent DNA synthesis in toluene-treated Escherichia coli. Biochemistry 15 2804 PMID: 779831
Sugar and McCaffrey (1998) Antifungal activity of 3'-deoxyadenosine (cordycepin). Antimicrob.Agents Chemother. 42 1424 PMID: 9624488
Kodama et al (2000) Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells. Biochem.Pharmacol. 59 273 PMID: 10609556
If you know of a relevant reference for Cordycepin, please let us know.
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Keywords: Cordycepin, Cordycepin supplier, RNA, synthesis, inhibitors, inhibits, Protein, DNA, DNA,, and, Synthesis, 2294, Tocris Bioscience
Citations for Cordycepin
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Currently there are no citations for Cordycepin. Do you know of a great paper that uses Cordycepin from Tocris? Please let us know.
Reviews for Cordycepin
Average Rating: 5 (Based on 1 Review.)
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Used for killing assay for in vitro cell culture. Cells were cultured for 24 hours before the addition of the compound into the media at low micromolar concentrations (indicated by the arrow).
Literature in this Area
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