Nucleoside analog that acts as an anticancer and antifungal agent. Can be converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA synthesis. Inhibits growth of various tumor cells in vitro.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 251.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.98 mL||19.9 mL||39.8 mL|
|5 mM||0.8 mL||3.98 mL||7.96 mL|
|10 mM||0.4 mL||1.99 mL||3.98 mL|
|50 mM||0.08 mL||0.4 mL||0.8 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Gumport and Edelhei et al (1976) The synthesis of 3'-dATP and its use as an inhibitor of ATP-dependent DNA synthesis in toluene-treated Escherichia coli. Biochemistry 15 2804 PMID: 779831
Sugar and McCaffrey (1998) Antifungal activity of 3'-deoxyadenosine (cordycepin). Antimicrob.Agents Chemother. 42 1424 PMID: 9624488
Kodama et al (2000) Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells. Biochem.Pharmacol. 59 273 PMID: 10609556
If you know of a relevant reference for Cordycepin, please let us know.
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