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Biological Activity for NSC 617145
NSC 617145 is a werner syndrome helicase (WRN) helicase inhibitor (IC50 = 250 nM); acts synergistically with Mitomycin C (Cat. No. 3258) to induce double-strand breaks and chromosomal abnormalities in vitro.
Technical Data for NSC 617145
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NSC 617145
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for NSC 617145
The following data is based on the product molecular weight 400.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||12.5 mL||62.49 mL||124.99 mL|
|1 mM||2.5 mL||12.5 mL||25 mL|
|2 mM||1.25 mL||6.25 mL||12.5 mL|
|10 mM||0.25 mL||1.25 mL||2.5 mL|
References for NSC 617145
References are publications that support the biological activity of the product.
Aggarwal et al (2013) Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway. Cancer Res. 73 5497 PMID: 23867477
Aggarwal et al (2013) Targeting an Achilles' heel of cancer with a WRN helicase inhibitor. Cell Cycle 12 3329 PMID: 24036544
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Keywords: NSC 617145, NSC 617145 supplier, NSC617145, Werner, syndrome, helicase, WRN, inhibitors, inhibits, double, strand, breaks, chromosomal, abnormalities, DNA,, RNA, and, Protein, Synthesis, 5340, Tocris Bioscience
Citations for NSC 617145
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Literature in this Area
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