NSC 617145

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Description: Werner syndrome helicase (WRN) inhibitor
Chemical Name: 1,1'-(2,2-Dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-pyrrole-2,5-dione
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity for NSC 617145

NSC 617145 is a werner syndrome helicase (WRN) helicase inhibitor (IC50 = 250 nM); acts synergistically with Mitomycin C (Cat. No. 3258) to induce double-strand breaks and chromosomal abnormalities in vitro.

Technical Data for NSC 617145

M. Wt 400.04
Formula C13H10Cl4N2O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 203115-63-3
PubChem ID 357621
Smiles CC(CN1C(C(Cl)=C(Cl)C1=O)=O)(C)CN2C(C(Cl)=C(Cl)C2=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NSC 617145

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 8 20

Preparing Stock Solutions for NSC 617145

The following data is based on the product molecular weight 400.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.5 mL 62.49 mL 124.99 mL
1 mM 2.5 mL 12.5 mL 25 mL
2 mM 1.25 mL 6.25 mL 12.5 mL
10 mM 0.25 mL 1.25 mL 2.5 mL

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References for NSC 617145

References are publications that support the biological activity of the product.

Aggarwal et al (2013) Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway. Cancer Res. 73 5497 PMID: 23867477

Aggarwal et al (2013) Targeting an Achilles' heel of cancer with a WRN helicase inhibitor. Cell Cycle 12 3329 PMID: 24036544

If you know of a relevant reference for NSC 617145, please let us know.

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Keywords: NSC 617145, NSC 617145 supplier, NSC617145, Werner, syndrome, helicase, WRN, inhibitors, inhibits, double, strand, breaks, chromosomal, abnormalities, DNA,, RNA, and, Protein, Synthesis, 5340, Tocris Bioscience

1 Citation for NSC 617145

Citations are publications that use Tocris products. Selected citations for NSC 617145 include:

Robert H et al (2021) WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells. Nat Commun 12 6561 PMID: 34772932

Do you know of a great paper that uses NSC 617145 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
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  • Ubiquitin Proteasome Pathway
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Huntington's Disease Research Product Guide

Huntington's Disease Research Product Guide

This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:

  • Somatic Instability
  • Proteolysis and Inclusion Bodies
  • Transcriptional Dysregulation
  • Mitochondrial Dysfunction
  • Nuclear-Cytoplasmic Transport Interference
  • Excitotoxicity
  • Stem Cells