NSC 617145

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Cat.No. 5340 - NSC 617145 | C13H10Cl4N2O4 | CAS No. 203115-63-3
Description: Werner syndrome helicase (WRN) inhibitor
Chemical Name: 1,1'-(2,2-Dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-pyrrole-2,5-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Werner syndrome helicase (WRN) helicase inhibitor (IC50 = 250 nM); acts synergistically with Mitomycin C (Cat. No. 3258) to induce double-strand breaks and chromosomal abnormalities in vitro.

Technical Data

M. Wt 400.04
Formula C13H10Cl4N2O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 203115-63-3
PubChem ID 357621
InChI Key PCOXPBOKDABARQ-UHFFFAOYSA-N
Smiles CC(CN1C(C(Cl)=C(Cl)C1=O)=O)(C)CN2C(C(Cl)=C(Cl)C2=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8 20

Preparing Stock Solutions

The following data is based on the product molecular weight 400.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.5 mL 25 mL
5 mM 0.5 mL 2.5 mL 5 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Aggarwal et al (2013) Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway. Cancer Res. 73 5497 PMID: 23867477

Aggarwal et al (2013) Targeting an Achilles' heel of cancer with a WRN helicase inhibitor. Cell Cycle 12 3329 PMID: 24036544


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Keywords: NSC617145 Werner syndrome helicase WRN helicase inhibitors inhibits double strand breaks chromosomal abnormalities DNA, RNA and Protein Synthesis

Citations for NSC 617145

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for NSC 617145

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