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Biological Activity for SSYA10-001
SSYA10-001 is a potent coronavirus helicase inhibitor (IC50 values are 0.046 μM and >3 μM for unwinding and ATPase, respectively). Inhibits SARS-CoV-2 Nsp13 helicase (IC50 = 3.5 μM), blocks dsDNA and dsRNA unwinding activities of Nsp13 (IC50 values are 5.3 μM and 5.7 μM respectively). In a SARS-CoV replicon assay SSYA10-001 inhibits (+) sense but not (-) sense RNA synthesis (EC50 = 8.95 μM). Also inhibits human papillomavirus E6 (IC50 = 10 μM)
Technical Data for SSYA10-001
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for SSYA10-001
References are publications that support the biological activity of the product.
Adedeji et al (2012) Severe acute respiratory syndrome coronavirus replication inhibitor that interferes with the nucleic acid unwinding of the viral helicase. Antimicrob.Agents Chemother. 56 4718 PMID: 22733076
Malecka et al (2014) Identification and characterization of small molecule human papillomavirus E6 inhibitors. ACS Chem.Biol. 9 1603 PMID: 24854633
Kumar and Lupoli (2020) Exploiting existing molecular scaffolds for long-term COVID treatment. ACS Med.Chem.Lett. 11 1357 PMID: 32665808
Spratt et al (2021) Coronavirus helicases: attractive and unique targets of antiviral drug-development and therapeutic patents. Expert Opin.Ther.Pat. 31 339 PMID: 33593200
Nizi et al (2022) Discovery of 2-phenylquinolines with broad-spectrum anti-coronavirus activity. ACS Med.Chem.Lett. 13 855 PMID: 35571875
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