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Description: DNA polymerase α, δ and ε inhibitor
Chemical Name: (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity for Aphidicolin

Aphidicolin is a DNA polymerase α, δ and ε inhibitor. Exhibits selectivity over DNA polymerase β and γ. Antimitotic, antibiotic and antiviral.

Technical Data for Aphidicolin

M. Wt 338.48
Formula C20H34O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 38966-21-1
PubChem ID 457964
Smiles OC[C@@]1(O)CC[C@@]23[C@](CC[C@]4([H])[C@]3(C)CC[C@@H](O)[C@@]4(C)CO)([H])C[C@@H]1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Aphidicolin

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 8.46 25

Preparing Stock Solutions for Aphidicolin

The following data is based on the product molecular weight 338.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 11.82 mL 59.09 mL 118.18 mL
1.25 mM 2.36 mL 11.82 mL 23.64 mL
2.5 mM 1.18 mL 5.91 mL 11.82 mL
12.5 mM 0.24 mL 1.18 mL 2.36 mL

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Product Datasheets for Aphidicolin

Certificate of Analysis / Product Datasheet
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References for Aphidicolin

References are publications that support the biological activity of the product.

Spadari et al (1984) Control of DNA replication and cell proliferation in eukaryotes by aphidicolin. Toxicol.Pathol. 12 143 PMID: 11478315

Bucknall et al (1973) Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicola. Antimicrob.Agents Chemother. 4 294 PMID: 4357181

Syväoja et al (1990) DNA polymerases α, δ, and ε: three distinct enzymes from HeLa cells. Proc.Natl.Acad.Sci.U.S.A. 87 6664 PMID: 1975694

If you know of a relevant reference for Aphidicolin, please let us know.

View Related Products by Product Action

View all DNA Polymerase Inhibitors

Keywords: Aphidicolin, Aphidicolin supplier, DNA, polymerase, alpha, α, delta, δ, epsilon, ε, inhibitors, inhibits, antimitotic, antibiotic, antiviral, Polymerase, DNA,, RNA, and, Protein, Synthesis, Antibiotics, Mitosis, Non-selective, Antivirals, 5736, Tocris Bioscience

1 Citation for Aphidicolin

Citations are publications that use Tocris products. Selected citations for Aphidicolin include:

Clifford J et al (2019) Genetic and Mechanical Regulation of Intestinal Smooth Muscle Development. Cell 179 90-105.e21 PMID: 31539501

Do you know of a great paper that uses Aphidicolin from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.