DNA polymerase α, δ and ε inhibitor. Exhibits selectivity over DNA polymerase β and γ. Antimitotic, antibiotic and antiviral.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 338.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.95 mL||14.77 mL||29.54 mL|
|5 mM||0.59 mL||2.95 mL||5.91 mL|
|10 mM||0.3 mL||1.48 mL||2.95 mL|
|50 mM||0.06 mL||0.3 mL||0.59 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Spadari et al (1984) Control of DNA replication and cell proliferation in eukaryotes by aphidicolin. Toxicol.Pathol. 12 143 PMID: 11478315
Bucknall et al (1973) Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicola. Antimicrob.Agents Chemother. 4 294 PMID: 4357181
Syväoja et al (1990) DNA polymerases α, δ, and ε: three distinct enzymes from HeLa cells. Proc.Natl.Acad.Sci.U.S.A. 87 6664 PMID: 1975694
If you know of a relevant reference for Aphidicolin, please let us know.
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Keywords: DNA polymerase alpha α delta δ epsilon ε inhibitors inhibits antimitotic antibiotic antiviral RNA/DNA Polymerase
Citations for Aphidicolin
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Literature in this Area
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.