Aphidicolin

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Cat.No. 5736 - Aphidicolin | C20H34O4 | CAS No. 38966-21-1
Description: DNA polymerase α, δ and ε inhibitor
Chemical Name: (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol
Datasheet
Citations
Literature

Biological Activity

DNA polymerase α, δ and ε inhibitor. Exhibits selectivity over DNA polymerase β and γ. Antimitotic, antibiotic and antiviral.

Technical Data

M. Wt 338.48
Formula C20H34O4
Storage Store at -20°C
CAS Number 38966-21-1
PubChem ID 457964
InChI Key NOFOAYPPHIUXJR-APNQCZIXSA-N
Smiles OC[C@@]1(O)CC[C@@]23[C@](CC[C@]4([H])[C@]3(C)CC[C@@H](O)[C@@]4(C)CO)([H])C[C@@H]1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.46 25

Preparing Stock Solutions

The following data is based on the product molecular weight 338.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.95 mL 14.77 mL 29.54 mL
5 mM 0.59 mL 2.95 mL 5.91 mL
10 mM 0.3 mL 1.48 mL 2.95 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Spadari et al (1984) Control of DNA replication and cell proliferation in eukaryotes by aphidicolin. Toxicol.Pathol. 12 143 PMID: 11478315

Bucknall et al (1973) Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicola. Antimicrob.Agents Chemother. 4 294 PMID: 4357181

Syväoja et al (1990) DNA polymerases α, δ, and ε: three distinct enzymes from HeLa cells. Proc.Natl.Acad.Sci.U.S.A. 87 6664 PMID: 1975694


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Keywords: DNA polymerase alpha α delta δ epsilon ε inhibitors inhibits antimitotic antibiotic antiviral RNA/DNA Polymerase

Citations for Aphidicolin

Citations are publications that use Tocris products.

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Literature in this Area

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Pathways for Aphidicolin

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