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Inhibitor of protein synthesis. Blocks elongation phase of translation by binding to the 60-S ribosome subunit. Antileukemic.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 545.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.83 mL||9.16 mL||18.33 mL|
|5 mM||0.37 mL||1.83 mL||3.67 mL|
|10 mM||0.18 mL||0.92 mL||1.83 mL|
|50 mM||0.04 mL||0.18 mL||0.37 mL|
References are publications that support the biological activity of the product.
Cai et al (2001) Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation, mitochondrial cytochrome c release and caspase activation. Leukemia 15 567 PMID: 11368358
Fresno et al (1977) Inhibition of translation in eukaryotic systems by harringtonine. Eur.J.Biochem. 72 323 PMID: 319998
Zhou et al (1995) Homoharringtonine: an effective new natural product in cancer chemotherapy. Bull.Cancer 82 987 PMID: 8745664
If you know of a relevant reference for Homoharringtonine, please let us know.
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Keywords: Homoharringtonine, Homoharringtonine supplier, inhibitors, inhibits, protein, synthesis, Antileukemic, agent, DNA,, RNA, and, Protein, Synthesis, 1416, Tocris Bioscience
3 Citations for Homoharringtonine
Citations are publications that use Tocris products. Selected citations for Homoharringtonine include:
Paige et al (2019) AMPK activation regulates P-body dynamics in mouse sensory neurons in vitro and in vivo. Neurobiol Pain 5 PMID: 31080914
Xia et al (2013) Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther 14 638 PMID: 23792643
Akef et al (2015) Splicing promotes the nuclear export of β-globin mRNA by overcoming nuclear retention elements. Cell J 21 1908 PMID: 26362019
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Reviews for Homoharringtonine
Average Rating: 5 (Based on 1 Review.)
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Used for killing assay for in vitro cell culture. Cells were cultured for 24 hours before the addition of the compound into the media at low micromolar concentrations (indicated by the arrow).
Literature in this Area
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