Homoharringtonine

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Cat.No. 1416 - Homoharringtonine | C29H39NO9 | CAS No. 26833-87-4
Description: Inhibitor of protein synthesis. Antileukemic agent
Chemical Name: Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Inhibitor of protein synthesis. Blocks elongation phase of translation by binding to the 60-S ribosome subunit. Antileukemic.

Technical Data

M. Wt 545.63
Formula C29H39NO9
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 26833-87-4
PubChem ID 285033
InChI Key HYFHYPWGAURHIV-JFIAXGOJSA-N
Smiles O=C([C@](CCCC(O)(C)C)(O)CC(OC)=O)O[C@@H]1C(OC)=C[C@@](N(CCC5)CCC2=CC4=C(OCO4)C=C23)5[C@]31[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 100 mM in DMSO and to 50 mM in ethanol

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Cai et al (2001) Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation, mitochondrial cytochrome c release and caspase activation. Leukemia 15 567 PMID: 11368358

Fresno et al (1977) Inhibition of translation in eukaryotic systems by harringtonine. Eur.J.Biochem. 72 323 PMID: 319998

Zhou et al (1995) Homoharringtonine: an effective new natural product in cancer chemotherapy. Bull.Cancer 82 987 PMID: 8745664


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2 Citations for Homoharringtonine

Citations are publications that use Tocris products. Selected citations for Homoharringtonine include:

Akef et al (2015) Splicing promotes the nuclear export of β-globin mRNA by overcoming nuclear retention elements. Cell J 21 1908 PMID: 26362019

Xia et al (2013) Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther 14 638 PMID: 23792643


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Literature in this Area

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Cancer

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