Inhibitor of protein synthesis. Blocks elongation phase of translation by binding to the 60-S ribosome subunit. Antileukemic.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 100 mM in DMSO and to 50 mM in ethanol|
References are publications that support the biological activity of the product.
Cai et al (2001) Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation, mitochondrial cytochrome c release and caspase activation. Leukemia 15 567 PMID: 11368358
Fresno et al (1977) Inhibition of translation in eukaryotic systems by harringtonine. Eur.J.Biochem. 72 323 PMID: 319998
Zhou et al (1995) Homoharringtonine: an effective new natural product in cancer chemotherapy. Bull.Cancer 82 987 PMID: 8745664
If you know of a relevant reference for Homoharringtonine, please let us know.
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Keywords: Homoharringtonine, Homoharringtonine supplier, inhibitors, inhibits, protein, synthesis, Antileukemic, agent, DNA,, RNA, and, Protein, Synthesis, 1416, Tocris Bioscience
2 Citations for Homoharringtonine
Citations are publications that use Tocris products. Selected citations for Homoharringtonine include:
Xia et al (2013) Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther 14 638 PMID: 23792643
Akef et al (2015) Splicing promotes the nuclear export of β-globin mRNA by overcoming nuclear retention elements. Cell J 21 1908 PMID: 26362019
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Used for killing assay for in vitro cell culture. Cells were cultured for 24 hours before the addition of the compound into the media at low micromolar concentrations (indicated by the arrow).
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