Inhibitor of protein synthesis. Blocks elongation phase of translation by binding to the 60-S ribosome subunit. Antileukemic.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 100 mM in DMSO and to 50 mM in ethanol|
Preparing Stock Solutions
The following data is based on the product molecular weight 545.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.83 mL||9.16 mL||18.33 mL|
|5 mM||0.37 mL||1.83 mL||3.67 mL|
|10 mM||0.18 mL||0.92 mL||1.83 mL|
|50 mM||0.04 mL||0.18 mL||0.37 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Cai et al (2001) Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation, mitochondrial cytochrome c release and caspase activation. Leukemia 15 567 PMID: 11368358
Fresno et al (1977) Inhibition of translation in eukaryotic systems by harringtonine. Eur.J.Biochem. 72 323 PMID: 319998
Zhou et al (1995) Homoharringtonine: an effective new natural product in cancer chemotherapy. Bull.Cancer 82 987 PMID: 8745664
If you know of a relevant reference for Homoharringtonine, please let us know.
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Keywords: inhibitors inhibits protein synthesis Antileukemic agent DNA, RNA and Protein Synthesis
2 Citations for Homoharringtonine
Citations are publications that use Tocris products. Selected citations for Homoharringtonine include:
Akef et al (2015) Splicing promotes the nuclear export of β-globin mRNA by overcoming nuclear retention elements. Cell J 21 1908 PMID: 26362019
Xia et al (2013) Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther 14 638 PMID: 23792643
Do you know of a great paper that uses Homoharringtonine from Tocris? If so please let us know.